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Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression.

Publication ,  Journal Article
Shao, R; Bao, S; Bai, X; Blanchette, C; Anderson, RM; Dang, T; Gishizky, ML; Marks, JR; Wang, X-F
Published in: Mol Cell Biol
May 2004

The late stages of human breast cancer development are poorly understood complex processes associated with the expression of genes by cancers that promote specific tumorigenic activities, such as angiogenesis. Here, we describe the identification of periostin as a mesenchyme-specific gene whose acquired expression by human breast cancers leads to a significant enhancement in tumor progression and angiogenesis. Undetectable in normal human breast tissues, periostin was found to be overexpressed by the vast majority of human primary breast cancers examined. Tumor cell lines engineered to overexpress periostin showed a phenotype of accelerated growth and angiogenesis as xenografts in immunocompromised animals. The underlying mechanism of periostin-mediated induction of angiogenesis was found to derive in part from the up-regulation of the vascular endothelial growth factor receptor Flk-1/KDR by endothelial cells through an integrin alpha(v)beta(3)-focal adhesion kinase-mediated signaling pathway. These findings demonstrate the presence of a novel mechanism by which tumor angiogenesis is acquired with the expression of a mesenchyme-specific gene as a crucial step in late stages of tumorigenesis.

Duke Scholars

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Published In

Mol Cell Biol

DOI

ISSN

0270-7306

Publication Date

May 2004

Volume

24

Issue

9

Start / End Page

3992 / 4003

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor Receptor-2
  • Up-Regulation
  • Transplantation, Heterologous
  • Signal Transduction
  • Protein-Tyrosine Kinases
  • Oligonucleotide Array Sequence Analysis
  • Neovascularization, Pathologic
  • Neoplasm Transplantation
  • Mice, SCID
  • Mice
 

Citation

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Shao, R., Bao, S., Bai, X., Blanchette, C., Anderson, R. M., Dang, T., … Wang, X.-F. (2004). Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Mol Cell Biol, 24(9), 3992–4003. https://doi.org/10.1128/MCB.24.9.3992-4003.2004
Shao, Rong, Shideng Bao, Xuefang Bai, Carrie Blanchette, Ryan M. Anderson, Tongyun Dang, Mikhail L. Gishizky, Jeffrey R. Marks, and Xiao-Fan Wang. “Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression.Mol Cell Biol 24, no. 9 (May 2004): 3992–4003. https://doi.org/10.1128/MCB.24.9.3992-4003.2004.
Shao, Rong, et al. “Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression.Mol Cell Biol, vol. 24, no. 9, May 2004, pp. 3992–4003. Pubmed, doi:10.1128/MCB.24.9.3992-4003.2004.
Shao R, Bao S, Bai X, Blanchette C, Anderson RM, Dang T, Gishizky ML, Marks JR, Wang X-F. Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Mol Cell Biol. 2004 May;24(9):3992–4003.

Published In

Mol Cell Biol

DOI

ISSN

0270-7306

Publication Date

May 2004

Volume

24

Issue

9

Start / End Page

3992 / 4003

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor Receptor-2
  • Up-Regulation
  • Transplantation, Heterologous
  • Signal Transduction
  • Protein-Tyrosine Kinases
  • Oligonucleotide Array Sequence Analysis
  • Neovascularization, Pathologic
  • Neoplasm Transplantation
  • Mice, SCID
  • Mice