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The mechanism of action of angiostatin: can you teach an old dog new tricks?

Publication ,  Journal Article
Moser, TL; Stack, MS; Wahl, ML; Pizzo, SV
Published in: Thromb Haemost
March 2002

What is angiostatin? In 1994, Folkman and colleagues published a landmark paper describing anti-tumor effects in mice with a purified fragment of plasminogen they named angiostatin (1). Although many papers have been published describing activities of cryptic polypeptides derived from plasminogen fragments, this was the first report which associated plasminogen kringles 1-4 as a suppressor of metastasis development. This review will describe what is known about the mechanism of action of angiostatin from the current literature.

Duke Scholars

Published In

Thromb Haemost

ISSN

0340-6245

Publication Date

March 2002

Volume

87

Issue

3

Start / End Page

394 / 401

Location

Germany

Related Subject Headings

  • Plasminogen
  • Peptide Fragments
  • Mitochondrial Proton-Translocating ATPases
  • Humans
  • Cardiovascular System & Hematology
  • Binding Sites
  • Antineoplastic Agents
  • Animals
  • Angiostatins
  • Angiogenesis Inhibitors
 

Citation

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MLA
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Moser, T. L., Stack, M. S., Wahl, M. L., & Pizzo, S. V. (2002). The mechanism of action of angiostatin: can you teach an old dog new tricks? Thromb Haemost, 87(3), 394–401.
Moser, Tammy L., M Sharon Stack, Miriam L. Wahl, and Salvatore V. Pizzo. “The mechanism of action of angiostatin: can you teach an old dog new tricks?Thromb Haemost 87, no. 3 (March 2002): 394–401.
Moser TL, Stack MS, Wahl ML, Pizzo SV. The mechanism of action of angiostatin: can you teach an old dog new tricks? Thromb Haemost. 2002 Mar;87(3):394–401.
Moser, Tammy L., et al. “The mechanism of action of angiostatin: can you teach an old dog new tricks?Thromb Haemost, vol. 87, no. 3, Mar. 2002, pp. 394–401.
Moser TL, Stack MS, Wahl ML, Pizzo SV. The mechanism of action of angiostatin: can you teach an old dog new tricks? Thromb Haemost. 2002 Mar;87(3):394–401.
Journal cover image

Published In

Thromb Haemost

ISSN

0340-6245

Publication Date

March 2002

Volume

87

Issue

3

Start / End Page

394 / 401

Location

Germany

Related Subject Headings

  • Plasminogen
  • Peptide Fragments
  • Mitochondrial Proton-Translocating ATPases
  • Humans
  • Cardiovascular System & Hematology
  • Binding Sites
  • Antineoplastic Agents
  • Animals
  • Angiostatins
  • Angiogenesis Inhibitors