The mechanism of action of angiostatin: can you teach an old dog new tricks?


Journal Article (Review)

What is angiostatin? In 1994, Folkman and colleagues published a landmark paper describing anti-tumor effects in mice with a purified fragment of plasminogen they named angiostatin (1). Although many papers have been published describing activities of cryptic polypeptides derived from plasminogen fragments, this was the first report which associated plasminogen kringles 1-4 as a suppressor of metastasis development. This review will describe what is known about the mechanism of action of angiostatin from the current literature.

Full Text

Duke Authors

Cited Authors

  • Moser, TL; Stack, MS; Wahl, ML; Pizzo, SV

Published Date

  • March 2002

Published In

Volume / Issue

  • 87 / 3

Start / End Page

  • 394 - 401

PubMed ID

  • 11916069

Pubmed Central ID

  • 11916069

International Standard Serial Number (ISSN)

  • 0340-6245


  • eng

Conference Location

  • Germany