Diphenylhydantoin enhances early adaptation in Aplysia giant neurons.
Publication
, Journal Article
Lewis, DV; Zbicz, KL; Nepp, ME; Colmers, WF; Wilson, WA
Published in: J Pharmacol Exp Ther
July 1981
Diphenylhydantoin effect on excitability in the molluscan giant neuron was investigated. This model of neuronal excitability was convenient for investigating drug mechanisms because the giant somata of these neurons have multiple current systems and can be voltage clamped. Current and voltage clamp methods were used to quantitate firing frequency and the slow membrane currents associated with changes in firing rate. Diphenylhydantoin enhanced the early rapid deceleration of firing of the cell in response to depolarizing current and blocked an early show inward current.
Duke Scholars
Published In
J Pharmacol Exp Ther
ISSN
0022-3565
Publication Date
July 1981
Volume
218
Issue
1
Start / End Page
41 / 45
Location
United States
Related Subject Headings
- Phenytoin
- Pharmacology & Pharmacy
- Neurons
- Electrophysiology
- Aplysia
- Animals
- Adaptation, Physiological
- Action Potentials
- 3214 Pharmacology and pharmaceutical sciences
- 1115 Pharmacology and Pharmaceutical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Lewis, D. V., Zbicz, K. L., Nepp, M. E., Colmers, W. F., & Wilson, W. A. (1981). Diphenylhydantoin enhances early adaptation in Aplysia giant neurons. J Pharmacol Exp Ther, 218(1), 41–45.
Lewis, D. V., K. L. Zbicz, M. E. Nepp, W. F. Colmers, and W. A. Wilson. “Diphenylhydantoin enhances early adaptation in Aplysia giant neurons.” J Pharmacol Exp Ther 218, no. 1 (July 1981): 41–45.
Lewis DV, Zbicz KL, Nepp ME, Colmers WF, Wilson WA. Diphenylhydantoin enhances early adaptation in Aplysia giant neurons. J Pharmacol Exp Ther. 1981 Jul;218(1):41–5.
Lewis, D. V., et al. “Diphenylhydantoin enhances early adaptation in Aplysia giant neurons.” J Pharmacol Exp Ther, vol. 218, no. 1, July 1981, pp. 41–45.
Lewis DV, Zbicz KL, Nepp ME, Colmers WF, Wilson WA. Diphenylhydantoin enhances early adaptation in Aplysia giant neurons. J Pharmacol Exp Ther. 1981 Jul;218(1):41–45.
Published In
J Pharmacol Exp Ther
ISSN
0022-3565
Publication Date
July 1981
Volume
218
Issue
1
Start / End Page
41 / 45
Location
United States
Related Subject Headings
- Phenytoin
- Pharmacology & Pharmacy
- Neurons
- Electrophysiology
- Aplysia
- Animals
- Adaptation, Physiological
- Action Potentials
- 3214 Pharmacology and pharmaceutical sciences
- 1115 Pharmacology and Pharmaceutical Sciences