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Diphenylhydantoin enhances early adaptation in Aplysia giant neurons.

Publication ,  Journal Article
Lewis, DV; Zbicz, KL; Nepp, ME; Colmers, WF; Wilson, WA
Published in: J Pharmacol Exp Ther
July 1981

Diphenylhydantoin effect on excitability in the molluscan giant neuron was investigated. This model of neuronal excitability was convenient for investigating drug mechanisms because the giant somata of these neurons have multiple current systems and can be voltage clamped. Current and voltage clamp methods were used to quantitate firing frequency and the slow membrane currents associated with changes in firing rate. Diphenylhydantoin enhanced the early rapid deceleration of firing of the cell in response to depolarizing current and blocked an early show inward current.

Duke Scholars

Published In

J Pharmacol Exp Ther

ISSN

0022-3565

Publication Date

July 1981

Volume

218

Issue

1

Start / End Page

41 / 45

Location

United States

Related Subject Headings

  • Phenytoin
  • Pharmacology & Pharmacy
  • Neurons
  • Electrophysiology
  • Aplysia
  • Animals
  • Adaptation, Physiological
  • Action Potentials
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Chicago
ICMJE
MLA
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Lewis, D. V., Zbicz, K. L., Nepp, M. E., Colmers, W. F., & Wilson, W. A. (1981). Diphenylhydantoin enhances early adaptation in Aplysia giant neurons. J Pharmacol Exp Ther, 218(1), 41–45.
Lewis, D. V., K. L. Zbicz, M. E. Nepp, W. F. Colmers, and W. A. Wilson. “Diphenylhydantoin enhances early adaptation in Aplysia giant neurons.J Pharmacol Exp Ther 218, no. 1 (July 1981): 41–45.
Lewis DV, Zbicz KL, Nepp ME, Colmers WF, Wilson WA. Diphenylhydantoin enhances early adaptation in Aplysia giant neurons. J Pharmacol Exp Ther. 1981 Jul;218(1):41–5.
Lewis, D. V., et al. “Diphenylhydantoin enhances early adaptation in Aplysia giant neurons.J Pharmacol Exp Ther, vol. 218, no. 1, July 1981, pp. 41–45.
Lewis DV, Zbicz KL, Nepp ME, Colmers WF, Wilson WA. Diphenylhydantoin enhances early adaptation in Aplysia giant neurons. J Pharmacol Exp Ther. 1981 Jul;218(1):41–45.

Published In

J Pharmacol Exp Ther

ISSN

0022-3565

Publication Date

July 1981

Volume

218

Issue

1

Start / End Page

41 / 45

Location

United States

Related Subject Headings

  • Phenytoin
  • Pharmacology & Pharmacy
  • Neurons
  • Electrophysiology
  • Aplysia
  • Animals
  • Adaptation, Physiological
  • Action Potentials
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences