A zebrafish model of germ cell aneuploidy.

Journal Article (Journal Article)

The high frequency of chromosomal nondisjunction in human germ cells impacts society in many ways. Yet, the etiology of chromosome disorders remains unclear. Using a zebrafish strain with a hypomorphic mutation in the kinase Mps1, a genetic association between reduced germ cell mitotic checkpoint activity and aneuploid progeny was recently established. This work highlights the exquisite sensitivity of vertebrate germ cells to disruptions in Mps1 function and mitotic checkpoint activity. In addition, it introduces the zebrafish as a promising tool with which to further investigate the origins of aneuploidy.

Full Text

Duke Authors

Cited Authors

  • Poss, KD

Published Date

  • October 2004

Published In

Volume / Issue

  • 3 / 10

Start / End Page

  • 1225 - 1226

PubMed ID

  • 15467466

Electronic International Standard Serial Number (EISSN)

  • 1551-4005

Digital Object Identifier (DOI)

  • 10.4161/cc.3.10.1170


  • eng

Conference Location

  • United States