A zebrafish model of germ cell aneuploidy.
Publication
, Journal Article
Poss, KD
Published in: Cell Cycle
October 2004
The high frequency of chromosomal nondisjunction in human germ cells impacts society in many ways. Yet, the etiology of chromosome disorders remains unclear. Using a zebrafish strain with a hypomorphic mutation in the kinase Mps1, a genetic association between reduced germ cell mitotic checkpoint activity and aneuploid progeny was recently established. This work highlights the exquisite sensitivity of vertebrate germ cells to disruptions in Mps1 function and mitotic checkpoint activity. In addition, it introduces the zebrafish as a promising tool with which to further investigate the origins of aneuploidy.
Duke Scholars
Published In
Cell Cycle
DOI
EISSN
1551-4005
Publication Date
October 2004
Volume
3
Issue
10
Start / End Page
1225 / 1226
Location
United States
Related Subject Headings
- Zebrafish
- Models, Animal
- Germ Cells
- Developmental Biology
- Animals
- Aneuploidy
- 0601 Biochemistry and Cell Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Poss, K. D. (2004). A zebrafish model of germ cell aneuploidy. Cell Cycle, 3(10), 1225–1226. https://doi.org/10.4161/cc.3.10.1170
Poss, Kenneth D. “A zebrafish model of germ cell aneuploidy.” Cell Cycle 3, no. 10 (October 2004): 1225–26. https://doi.org/10.4161/cc.3.10.1170.
Poss KD. A zebrafish model of germ cell aneuploidy. Cell Cycle. 2004 Oct;3(10):1225–6.
Poss, Kenneth D. “A zebrafish model of germ cell aneuploidy.” Cell Cycle, vol. 3, no. 10, Oct. 2004, pp. 1225–26. Pubmed, doi:10.4161/cc.3.10.1170.
Poss KD. A zebrafish model of germ cell aneuploidy. Cell Cycle. 2004 Oct;3(10):1225–1226.
Published In
Cell Cycle
DOI
EISSN
1551-4005
Publication Date
October 2004
Volume
3
Issue
10
Start / End Page
1225 / 1226
Location
United States
Related Subject Headings
- Zebrafish
- Models, Animal
- Germ Cells
- Developmental Biology
- Animals
- Aneuploidy
- 0601 Biochemistry and Cell Biology