Enzymatic nanolithography of a self-assembled oligonucleotide monolayer on gold.
Journal Article (Journal Article)
This paper describes a simple strategy to biochemically manipulate a surface at the nanoscale by enzyme dip-pen nanolithography using an endonuclease (DNase I) that is directly patterned on a self-assembled monolayer presenting a terminal oligonucleotide. Physisorbed nanopatterns of DNase I carried out nanoscale enzymology at the surface creating oligonucleotide patterns with the fidelity of the patterned enzyme because of the affinity of the enzyme for the immobilized, oligonucleotide substrate.
- Hyun, J; Kim, J; Craig, SL; Chilkoti, A
- April 2004
Volume / Issue
- 126 / 15
Start / End Page
- 4770 - 4771
Electronic International Standard Serial Number (EISSN)
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)