Single-voxel 1H PRESS at 4.0 T: precision and variability of measurements in anterior cingulate and hippocampus.

Journal Article

The precision [coefficient of variation or CV (%) = 100SD/X] of single-voxel point resolved spectroscopic data was characterized bilaterally, in anterior cingulate and in hippocampus, at 4.0 T in a healthy subject. Data acquisition was replicated 10 times after voxel repositioning and readjusting higher order shims. Precision measurements show that the scan-to-scan precision is better in anterior cingulate than in hippocampus, with an average CV of 9.2% (for total NAA, tCho and Cr) in anterior cingulate and 13.9% in hippocampus. Variability measurements made by the same method in 24 healthy subjects and in 29 schizophrenia patients showed that there is substantial biological variability in metabolite levels, even in healthy subjects. Simple calculations suggest that more than 200 subjects would be needed to detect a 5% difference in NAA between patients and controls.

Full Text

Duke Authors

Cited Authors

  • Venkatraman, TN; Hamer, RM; Perkins, DO; Song, AW; Lieberman, JA; Steen, RG

Published Date

  • June 2006

Published In

Volume / Issue

  • 19 / 4

Start / End Page

  • 484 - 491

PubMed ID

  • 16763968

Pubmed Central ID

  • 16763968

International Standard Serial Number (ISSN)

  • 0952-3480

Digital Object Identifier (DOI)

  • 10.1002/nbm.1055


  • eng

Conference Location

  • England