The germinal center: a crucible for lymphocyte selection.

Journal Article (Journal Article;Review)

Antigen first activates T and B lymphocytes in the T-cell areas of secondary lymphoid tissues where cognate- and costimulus-dependent proliferation expands the population of reactive lymphocytes. Selected T- and B-cell progeny from this population migrate into B-cell zones to form germinal centers (GC), where intense proliferation, apoptosis, and V(D)J hypermutation takes place. It is now known that each of these processes occur in both compartments of GC lymphocytes and that the GC T-cell represents an unusual Thy-1- subset of alpha beta T-helper cells that may represent a terminally differentiated cell that is lost with the end of the GC reaction.

Full Text

Duke Authors

Cited Authors

  • Kelsoe, G

Published Date

  • June 1996

Published In

Volume / Issue

  • 8 / 3

Start / End Page

  • 179 - 184

PubMed ID

  • 8738917

International Standard Serial Number (ISSN)

  • 1044-5323

Digital Object Identifier (DOI)

  • 10.1006/smim.1996.0022


  • eng

Conference Location

  • England