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The germinal center: a crucible for lymphocyte selection.

Publication ,  Journal Article
Kelsoe, G
Published in: Semin Immunol
June 1996

Antigen first activates T and B lymphocytes in the T-cell areas of secondary lymphoid tissues where cognate- and costimulus-dependent proliferation expands the population of reactive lymphocytes. Selected T- and B-cell progeny from this population migrate into B-cell zones to form germinal centers (GC), where intense proliferation, apoptosis, and V(D)J hypermutation takes place. It is now known that each of these processes occur in both compartments of GC lymphocytes and that the GC T-cell represents an unusual Thy-1- subset of alpha beta T-helper cells that may represent a terminally differentiated cell that is lost with the end of the GC reaction.

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Published In

Semin Immunol

DOI

ISSN

1044-5323

Publication Date

June 1996

Volume

8

Issue

3

Start / End Page

179 / 184

Location

England

Related Subject Headings

  • T-Lymphocytes
  • Mutation
  • Molecular Sequence Data
  • Lymphocyte Activation
  • Immunology
  • Humans
  • Germinal Center
  • Base Sequence
  • Antibody Formation
  • Animals
 

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Kelsoe, G. (1996). The germinal center: a crucible for lymphocyte selection. Semin Immunol, 8(3), 179–184. https://doi.org/10.1006/smim.1996.0022
Kelsoe, G. “The germinal center: a crucible for lymphocyte selection.Semin Immunol 8, no. 3 (June 1996): 179–84. https://doi.org/10.1006/smim.1996.0022.
Kelsoe G. The germinal center: a crucible for lymphocyte selection. Semin Immunol. 1996 Jun;8(3):179–84.
Kelsoe, G. “The germinal center: a crucible for lymphocyte selection.Semin Immunol, vol. 8, no. 3, June 1996, pp. 179–84. Pubmed, doi:10.1006/smim.1996.0022.
Kelsoe G. The germinal center: a crucible for lymphocyte selection. Semin Immunol. 1996 Jun;8(3):179–184.
Journal cover image

Published In

Semin Immunol

DOI

ISSN

1044-5323

Publication Date

June 1996

Volume

8

Issue

3

Start / End Page

179 / 184

Location

England

Related Subject Headings

  • T-Lymphocytes
  • Mutation
  • Molecular Sequence Data
  • Lymphocyte Activation
  • Immunology
  • Humans
  • Germinal Center
  • Base Sequence
  • Antibody Formation
  • Animals