Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow.

Journal Article

The coordinated production of leukocytes in bone marrow is crucial for innate and adaptive immunity. Inflammation alters normal leukocyte production by promoting granulopoiesis over lymphopoiesis, a response that supports the reactive neutrophilia that follows infection. Here we demonstrate that this specialization for granulopoiesis is determined by inflammation-induced reductions of growth and retention factors, most significantly stem cell factor and CXCL12, which act preferentially to inhibit lymphoid development. These hierarchical effects suggest that the normal equilibrium of leukocyte production in bone marrow is determined by lymphopoiesis' higher demand for specific growth factors and/or retention signals. Inflammation regulates this balance by reducing growth factors that have less impact on developing neutrophils than lymphocytes. We demonstrate that granulopoiesis and lymphopoiesis are coupled specifically in the bone marrow by development in a common niche and propose that the leukopoietic equilibrium is specified by limiting amounts of developmental resources.

Full Text

Duke Authors

Cited Authors

  • Ueda, Y; Kondo, M; Kelsoe, G

Published Date

  • June 6, 2005

Published In

Volume / Issue

  • 201 / 11

Start / End Page

  • 1771 - 1780

PubMed ID

  • 15939792

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.20041419

Language

  • eng

Conference Location

  • United States