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Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow.

Publication ,  Journal Article
Ueda, Y; Kondo, M; Kelsoe, G
Published in: J Exp Med
June 6, 2005

The coordinated production of leukocytes in bone marrow is crucial for innate and adaptive immunity. Inflammation alters normal leukocyte production by promoting granulopoiesis over lymphopoiesis, a response that supports the reactive neutrophilia that follows infection. Here we demonstrate that this specialization for granulopoiesis is determined by inflammation-induced reductions of growth and retention factors, most significantly stem cell factor and CXCL12, which act preferentially to inhibit lymphoid development. These hierarchical effects suggest that the normal equilibrium of leukocyte production in bone marrow is determined by lymphopoiesis' higher demand for specific growth factors and/or retention signals. Inflammation regulates this balance by reducing growth factors that have less impact on developing neutrophils than lymphocytes. We demonstrate that granulopoiesis and lymphopoiesis are coupled specifically in the bone marrow by development in a common niche and propose that the leukopoietic equilibrium is specified by limiting amounts of developmental resources.

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Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

June 6, 2005

Volume

201

Issue

11

Start / End Page

1771 / 1780

Location

United States

Related Subject Headings

  • Myelopoiesis
  • Mice
  • Lymphopoiesis
  • Lymphocytes
  • Inflammation
  • Immunology
  • Immunity, Innate
  • Granulocytes
  • Chemokines, CXC
  • Chemokine CXCL12
 

Citation

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Ueda, Y., Kondo, M., & Kelsoe, G. (2005). Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow. J Exp Med, 201(11), 1771–1780. https://doi.org/10.1084/jem.20041419
Ueda, Yoshihiro, Motonari Kondo, and Garnett Kelsoe. “Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow.J Exp Med 201, no. 11 (June 6, 2005): 1771–80. https://doi.org/10.1084/jem.20041419.
Ueda Y, Kondo M, Kelsoe G. Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow. J Exp Med. 2005 Jun 6;201(11):1771–80.
Ueda, Yoshihiro, et al. “Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow.J Exp Med, vol. 201, no. 11, June 2005, pp. 1771–80. Pubmed, doi:10.1084/jem.20041419.
Ueda Y, Kondo M, Kelsoe G. Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow. J Exp Med. 2005 Jun 6;201(11):1771–1780.

Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

June 6, 2005

Volume

201

Issue

11

Start / End Page

1771 / 1780

Location

United States

Related Subject Headings

  • Myelopoiesis
  • Mice
  • Lymphopoiesis
  • Lymphocytes
  • Inflammation
  • Immunology
  • Immunity, Innate
  • Granulocytes
  • Chemokines, CXC
  • Chemokine CXCL12