Family-based case-control study of MAOA and MAOB polymorphisms in Parkinson disease.

Published

Journal Article

Monoamine oxidase (MAO) is an enzyme regulating metabolism of neurotransmitters such as dopamine. Two distinct forms of enzyme, encoded by genes MAOA and MAOB located on the X chromosome, have been considered as possible factors in the pathogenesis of Parkinson disease (PD). Previous association studies of PD and MAO genes reported inconsistent results. In this study, we used a large family-based data set to test associations between MAO genes and a risk of PD. The data set includes 298 female discordant sibpairs and 348 male discordant sibpairs. For this study, all subjects analyzed were white and families with known parkin mutations were removed. We analyzed 15 single nucleotide polymorphisms (SNPs) and a dinucleotide repeat marker in the MAO genes. Association was found with the intron 13 SNP of MAOB in the female subset (P = 0.02). No significant association was found in the male subset. Our results add to the evidence of involvement of MAOB in PD and suggest that the effect may be stronger in women.

Full Text

Duke Authors

Cited Authors

  • Kang, SJ; Scott, WK; Li, Y-J; Hauser, MA; van der Walt, JM; Fujiwara, K; Mayhew, GM; West, SG; Vance, JM; Martin, ER

Published Date

  • December 2006

Published In

Volume / Issue

  • 21 / 12

Start / End Page

  • 2175 - 2180

PubMed ID

  • 17044053

Pubmed Central ID

  • 17044053

Electronic International Standard Serial Number (EISSN)

  • 1531-8257

International Standard Serial Number (ISSN)

  • 0885-3185

Digital Object Identifier (DOI)

  • 10.1002/mds.21151

Language

  • eng