Recent advances in the neurochemical pathology of Alzheimer's disease. Studies of neuropeptides, cholinergic function and Alzheimer's disease-associated protein.

Journal Article (Journal Article)

Our findings from three postmortem tissue studies in Alzheimer's disease (AD) are presented. We investigated (1) alterations in somatostatin (SRIF) and corticotropin-releasing factor (CRF) in AD; (2) regulatory changes in presynaptic cholinergic function in AD; and (3) use of Alzheimer's disease-associated protein (ADAP) as a diagnostic test for AD in postmortem tissue. Taken together, these findings reveal marked reductions in SRIF and CRF concentrations in many cerebrocortical areas in AD, a marked up-regulation of cholinergic neuronal activity in surviving cholinergic neurons in AD, and excellent specificity and sensitivity for the use of the ADAP assay as a diagnostic test for AD in postmortem tissue.

Full Text

Duke Authors

Cited Authors

  • Nemeroff, CB; Bissette, G; Slotkin, TA; Seidler, FJ; Miller, BE; Ghanbari, H

Published Date

  • 1991

Published In

Volume / Issue

  • 640 /

Start / End Page

  • 193 - 196

PubMed ID

  • 1685644

International Standard Serial Number (ISSN)

  • 0077-8923

Digital Object Identifier (DOI)

  • 10.1111/j.1749-6632.1991.tb00216.x


  • eng

Conference Location

  • United States