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Recent advances in the neurochemical pathology of Alzheimer's disease. Studies of neuropeptides, cholinergic function and Alzheimer's disease-associated protein.

Publication ,  Journal Article
Nemeroff, CB; Bissette, G; Slotkin, TA; Seidler, FJ; Miller, BE; Ghanbari, H
Published in: Ann N Y Acad Sci
1991

Our findings from three postmortem tissue studies in Alzheimer's disease (AD) are presented. We investigated (1) alterations in somatostatin (SRIF) and corticotropin-releasing factor (CRF) in AD; (2) regulatory changes in presynaptic cholinergic function in AD; and (3) use of Alzheimer's disease-associated protein (ADAP) as a diagnostic test for AD in postmortem tissue. Taken together, these findings reveal marked reductions in SRIF and CRF concentrations in many cerebrocortical areas in AD, a marked up-regulation of cholinergic neuronal activity in surviving cholinergic neurons in AD, and excellent specificity and sensitivity for the use of the ADAP assay as a diagnostic test for AD in postmortem tissue.

Duke Scholars

Published In

Ann N Y Acad Sci

DOI

ISSN

0077-8923

Publication Date

1991

Volume

640

Start / End Page

193 / 196

Location

United States

Related Subject Headings

  • Somatostatin
  • Neurons
  • Humans
  • General Science & Technology
  • Corticotropin-Releasing Hormone
  • Cholinergic Fibers
  • Amyloid beta-Peptides
  • Alzheimer Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nemeroff, C. B., Bissette, G., Slotkin, T. A., Seidler, F. J., Miller, B. E., & Ghanbari, H. (1991). Recent advances in the neurochemical pathology of Alzheimer's disease. Studies of neuropeptides, cholinergic function and Alzheimer's disease-associated protein. Ann N Y Acad Sci, 640, 193–196. https://doi.org/10.1111/j.1749-6632.1991.tb00216.x
Nemeroff, C. B., G. Bissette, T. A. Slotkin, F. J. Seidler, B. E. Miller, and H. Ghanbari. “Recent advances in the neurochemical pathology of Alzheimer's disease. Studies of neuropeptides, cholinergic function and Alzheimer's disease-associated protein.Ann N Y Acad Sci 640 (1991): 193–96. https://doi.org/10.1111/j.1749-6632.1991.tb00216.x.
Nemeroff CB, Bissette G, Slotkin TA, Seidler FJ, Miller BE, Ghanbari H. Recent advances in the neurochemical pathology of Alzheimer's disease. Studies of neuropeptides, cholinergic function and Alzheimer's disease-associated protein. Ann N Y Acad Sci. 1991;640:193–6.
Nemeroff, C. B., et al. “Recent advances in the neurochemical pathology of Alzheimer's disease. Studies of neuropeptides, cholinergic function and Alzheimer's disease-associated protein.Ann N Y Acad Sci, vol. 640, 1991, pp. 193–96. Pubmed, doi:10.1111/j.1749-6632.1991.tb00216.x.
Nemeroff CB, Bissette G, Slotkin TA, Seidler FJ, Miller BE, Ghanbari H. Recent advances in the neurochemical pathology of Alzheimer's disease. Studies of neuropeptides, cholinergic function and Alzheimer's disease-associated protein. Ann N Y Acad Sci. 1991;640:193–196.
Journal cover image

Published In

Ann N Y Acad Sci

DOI

ISSN

0077-8923

Publication Date

1991

Volume

640

Start / End Page

193 / 196

Location

United States

Related Subject Headings

  • Somatostatin
  • Neurons
  • Humans
  • General Science & Technology
  • Corticotropin-Releasing Hormone
  • Cholinergic Fibers
  • Amyloid beta-Peptides
  • Alzheimer Disease