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The effect of a low-carbohydrate, ketogenic diet on nonalcoholic fatty liver disease: a pilot study.

Publication ,  Journal Article
Tendler, D; Lin, S; Yancy, WS; Mavropoulos, J; Sylvestre, P; Rockey, DC; Westman, EC
Published in: Dig Dis Sci
February 2007

Nonalcoholic fatty liver disease is an increasingly common condition that may progress to hepatic cirrhosis. This pilot study evaluated the effects of a low-carbohydrate, ketogenic diet on obesity-associated fatty liver disease. Five patients with a mean body mass index of 36.4 kg/m(2) and biopsy evidence of fatty liver disease were instructed to follow the diet (<20 g/d of carbohydrate) with nutritional supplementation for 6 months. Patients returned for group meetings biweekly for 3 months, then monthly for the second 3 months. The mean weight change was -12.8 kg (range 0 to -25.9 kg). Four of 5 posttreatment liver biopsies showed histologic improvements in steatosis (P=.02) inflammatory grade (P=.02), and fibrosis (P=.07). Six months of a low-carbohydrate, ketogenic diet led to significant weight loss and histologic improvement of fatty liver disease. Further research is into this approach is warranted.

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Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

February 2007

Volume

52

Issue

2

Start / End Page

589 / 593

Location

United States

Related Subject Headings

  • Weight Loss
  • Treatment Outcome
  • Prospective Studies
  • Pilot Projects
  • Obesity
  • Middle Aged
  • Male
  • Liver Cirrhosis
  • Ketones
  • Ketone Bodies
 

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Tendler, D., Lin, S., Yancy, W. S., Mavropoulos, J., Sylvestre, P., Rockey, D. C., & Westman, E. C. (2007). The effect of a low-carbohydrate, ketogenic diet on nonalcoholic fatty liver disease: a pilot study. Dig Dis Sci, 52(2), 589–593. https://doi.org/10.1007/s10620-006-9433-5
Tendler, David, Sauyu Lin, William S. Yancy, John Mavropoulos, Pam Sylvestre, Don C. Rockey, and Eric C. Westman. “The effect of a low-carbohydrate, ketogenic diet on nonalcoholic fatty liver disease: a pilot study.Dig Dis Sci 52, no. 2 (February 2007): 589–93. https://doi.org/10.1007/s10620-006-9433-5.
Tendler D, Lin S, Yancy WS, Mavropoulos J, Sylvestre P, Rockey DC, et al. The effect of a low-carbohydrate, ketogenic diet on nonalcoholic fatty liver disease: a pilot study. Dig Dis Sci. 2007 Feb;52(2):589–93.
Tendler, David, et al. “The effect of a low-carbohydrate, ketogenic diet on nonalcoholic fatty liver disease: a pilot study.Dig Dis Sci, vol. 52, no. 2, Feb. 2007, pp. 589–93. Pubmed, doi:10.1007/s10620-006-9433-5.
Tendler D, Lin S, Yancy WS, Mavropoulos J, Sylvestre P, Rockey DC, Westman EC. The effect of a low-carbohydrate, ketogenic diet on nonalcoholic fatty liver disease: a pilot study. Dig Dis Sci. 2007 Feb;52(2):589–593.
Journal cover image

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

February 2007

Volume

52

Issue

2

Start / End Page

589 / 593

Location

United States

Related Subject Headings

  • Weight Loss
  • Treatment Outcome
  • Prospective Studies
  • Pilot Projects
  • Obesity
  • Middle Aged
  • Male
  • Liver Cirrhosis
  • Ketones
  • Ketone Bodies