The effect of a low-carbohydrate, ketogenic diet on nonalcoholic fatty liver disease: a pilot study.

Published

Journal Article

Nonalcoholic fatty liver disease is an increasingly common condition that may progress to hepatic cirrhosis. This pilot study evaluated the effects of a low-carbohydrate, ketogenic diet on obesity-associated fatty liver disease. Five patients with a mean body mass index of 36.4 kg/m(2) and biopsy evidence of fatty liver disease were instructed to follow the diet (<20 g/d of carbohydrate) with nutritional supplementation for 6 months. Patients returned for group meetings biweekly for 3 months, then monthly for the second 3 months. The mean weight change was -12.8 kg (range 0 to -25.9 kg). Four of 5 posttreatment liver biopsies showed histologic improvements in steatosis (P=.02) inflammatory grade (P=.02), and fibrosis (P=.07). Six months of a low-carbohydrate, ketogenic diet led to significant weight loss and histologic improvement of fatty liver disease. Further research is into this approach is warranted.

Full Text

Duke Authors

Cited Authors

  • Tendler, D; Lin, S; Yancy, WS; Mavropoulos, J; Sylvestre, P; Rockey, DC; Westman, EC

Published Date

  • February 2007

Published In

Volume / Issue

  • 52 / 2

Start / End Page

  • 589 - 593

PubMed ID

  • 17219068

Pubmed Central ID

  • 17219068

Electronic International Standard Serial Number (EISSN)

  • 1573-2568

International Standard Serial Number (ISSN)

  • 0163-2116

Digital Object Identifier (DOI)

  • 10.1007/s10620-006-9433-5

Language

  • eng