Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness.

Published

Journal Article

Asthma is a ubiquitous disease with a broad range of clinical phenotypes. To better understand the complex genetic and environmental interactions underlying asthma, we compared the gene-gene interactions of four genetically distinct mouse strains that demonstrate biologically distinct responses to allergen. Using DNA microarrays and knock-out mouse studies, we showed that CCR5 plays a definitive role in the development of ovalbumin-induced allergic airway inflammatory disease. In addition, gene expression profiling data have revealed other potential novel targets for therapeutics-based research and has enhanced the understanding of the molecular mechanisms underlying the etiology of "asthma."

Full Text

Duke Authors

Cited Authors

  • Walker, JKL; Ahumada, A; Frank, B; Gaspard, R; Berman, K; Quackenbush, J; Schwartz, DA

Published Date

  • June 2006

Published In

Volume / Issue

  • 34 / 6

Start / End Page

  • 711 - 718

PubMed ID

  • 16474097

Pubmed Central ID

  • 16474097

Electronic International Standard Serial Number (EISSN)

  • 1535-4989

International Standard Serial Number (ISSN)

  • 1044-1549

Digital Object Identifier (DOI)

  • 10.1165/rcmb.2005-0314OC

Language

  • eng