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Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness.

Publication ,  Journal Article
Walker, JK; Ahumada, A; Frank, B; Gaspard, R; Berman, K; Quackenbush, J; Schwartz, DA
Published in: American journal of respiratory cell and molecular biology
June 2006

Asthma is a ubiquitous disease with a broad range of clinical phenotypes. To better understand the complex genetic and environmental interactions underlying asthma, we compared the gene-gene interactions of four genetically distinct mouse strains that demonstrate biologically distinct responses to allergen. Using DNA microarrays and knock-out mouse studies, we showed that CCR5 plays a definitive role in the development of ovalbumin-induced allergic airway inflammatory disease. In addition, gene expression profiling data have revealed other potential novel targets for therapeutics-based research and has enhanced the understanding of the molecular mechanisms underlying the etiology of "asthma."

Duke Scholars

Published In

American journal of respiratory cell and molecular biology

ISSN

1044-1549

Publication Date

June 2006

Volume

34

Issue

6

Start / End Page

711 / 718

Location

united states

Related Subject Headings

  • Respiratory System
  • Respiratory Hypersensitivity
  • Receptors, CCR5
  • Phenotype
  • Ovalbumin
  • Oligonucleotide Array Sequence Analysis
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Walker, J. K., Ahumada, A., Frank, B., Gaspard, R., Berman, K., Quackenbush, J., & Schwartz, D. A. (2006). Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness. American Journal of Respiratory Cell and Molecular Biology, 34(6), 711–718.
Walker, J. K., A. Ahumada, B. Frank, R. Gaspard, K. Berman, J. Quackenbush, and D. A. Schwartz. “Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness.American Journal of Respiratory Cell and Molecular Biology 34, no. 6 (June 2006): 711–18.
Walker JK, Ahumada A, Frank B, Gaspard R, Berman K, Quackenbush J, et al. Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness. American journal of respiratory cell and molecular biology. 2006 Jun;34(6):711–8.
Walker, J. K., et al. “Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness.American Journal of Respiratory Cell and Molecular Biology, vol. 34, no. 6, June 2006, pp. 711–18.
Walker JK, Ahumada A, Frank B, Gaspard R, Berman K, Quackenbush J, Schwartz DA. Multistrain genetic comparisons reveal CCR5 as a receptor involved in airway hyperresponsiveness. American journal of respiratory cell and molecular biology. 2006 Jun;34(6):711–718.

Published In

American journal of respiratory cell and molecular biology

ISSN

1044-1549

Publication Date

June 2006

Volume

34

Issue

6

Start / End Page

711 / 718

Location

united states

Related Subject Headings

  • Respiratory System
  • Respiratory Hypersensitivity
  • Receptors, CCR5
  • Phenotype
  • Ovalbumin
  • Oligonucleotide Array Sequence Analysis
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice