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Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline.

Publication ,  Journal Article
Behera, MA; Feng, L; Yonish, B; Catherino, W; Jung, S-H; Leppert, P
Published in: Reprod Sci
December 2007

Uterine fibroids are composed of altered collagen fibrils and represent an arrested response to injury-initiating fibrosis. In many tissues, TSP-1 is secreted by adult macrophages and monocytes upon wounding and is involved in the activation of transforming growth factor beta. In the absence of TSP-1, the orchestrated process of wound healing is impaired. The authors obtained tissue from the edge and center of fibroids at the time of hysterectomy and compared them with adjacent myometrium. The pattern of TSP-1 and TSP-2 expression was correlated to that of COL1A1 and COL3A1. Collagen and hydroxyproline were increased in fibroids. Thrombospondin-1 was consistently underexpressed in both the edge and center of the fibroids, while COL1A1 and COL3A1 were consistently overexpressed. However, TSP-2 was inconsistently expressed. These findings lead to the conclusion that the underexpression of TSP-1 may contribute to the overall development of uterine fibroids.

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Published In

Reprod Sci

DOI

EISSN

1933-7205

Publication Date

December 2007

Volume

14

Issue

8 Suppl

Start / End Page

63 / 76

Location

United States

Related Subject Headings

  • Uterine Neoplasms
  • Thrombospondins
  • Thrombospondin 1
  • RNA, Messenger
  • Polymerase Chain Reaction
  • Oligonucleotide Array Sequence Analysis
  • Obstetrics & Reproductive Medicine
  • Myometrium
  • Matrix Metalloproteinase 2
  • Leiomyoma
 

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Behera, M. A., Feng, L., Yonish, B., Catherino, W., Jung, S.-H., & Leppert, P. (2007). Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline. Reprod Sci, 14(8 Suppl), 63–76. https://doi.org/10.1177/1933719107309591
Behera, Millie A., Liping Feng, Bryan Yonish, William Catherino, Sin-Ho Jung, and Phyllis Leppert. “Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline.Reprod Sci 14, no. 8 Suppl (December 2007): 63–76. https://doi.org/10.1177/1933719107309591.
Journal cover image

Published In

Reprod Sci

DOI

EISSN

1933-7205

Publication Date

December 2007

Volume

14

Issue

8 Suppl

Start / End Page

63 / 76

Location

United States

Related Subject Headings

  • Uterine Neoplasms
  • Thrombospondins
  • Thrombospondin 1
  • RNA, Messenger
  • Polymerase Chain Reaction
  • Oligonucleotide Array Sequence Analysis
  • Obstetrics & Reproductive Medicine
  • Myometrium
  • Matrix Metalloproteinase 2
  • Leiomyoma