Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo.
Journal Article (Journal Article)
A key characteristic of stem cells and cancer cells is their ability to self-renew. To test if Wnt signaling can regulate the self-renewal of both stem cells and cancer cells in the hematopoietic system, we developed mice that lack beta-catenin in their hematopoietic cells. Here we show that beta-catenin-deficient mice can form HSCs, but that these cells are deficient in long-term growth and maintenance. Moreover, beta-catenin deletion causes a profound reduction in the ability of mice to develop BCR-ABL-induced chronic myelogenous leukemia (CML), while allowing progression of acute lymphocytic leukemia (ALL). These studies demonstrate that Wnt signaling is required for the self-renewal of normal and neoplastic stem cells in the hematopoietic system.
Full Text
Duke Authors
Cited Authors
- Zhao, C; Blum, J; Chen, A; Kwon, HY; Jung, SH; Cook, JM; Lagoo, A; Reya, T
Published Date
- December 2007
Published In
Volume / Issue
- 12 / 6
Start / End Page
- 528 - 541
PubMed ID
- 18068630
Pubmed Central ID
- PMC2262869
International Standard Serial Number (ISSN)
- 1535-6108
Digital Object Identifier (DOI)
- 10.1016/j.ccr.2007.11.003
Language
- eng
Conference Location
- United States