Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo.

Published

Journal Article

A key characteristic of stem cells and cancer cells is their ability to self-renew. To test if Wnt signaling can regulate the self-renewal of both stem cells and cancer cells in the hematopoietic system, we developed mice that lack beta-catenin in their hematopoietic cells. Here we show that beta-catenin-deficient mice can form HSCs, but that these cells are deficient in long-term growth and maintenance. Moreover, beta-catenin deletion causes a profound reduction in the ability of mice to develop BCR-ABL-induced chronic myelogenous leukemia (CML), while allowing progression of acute lymphocytic leukemia (ALL). These studies demonstrate that Wnt signaling is required for the self-renewal of normal and neoplastic stem cells in the hematopoietic system.

Full Text

Duke Authors

Cited Authors

  • Zhao, C; Blum, J; Chen, A; Kwon, HY; Jung, SH; Cook, JM; Lagoo, A; Reya, T

Published Date

  • December 2007

Published In

Volume / Issue

  • 12 / 6

Start / End Page

  • 528 - 541

PubMed ID

  • 18068630

Pubmed Central ID

  • 18068630

Electronic International Standard Serial Number (EISSN)

  • 1878-3686

International Standard Serial Number (ISSN)

  • 1535-6108

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2007.11.003

Language

  • eng