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Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo.

Publication ,  Journal Article
Zhao, C; Blum, J; Chen, A; Kwon, HY; Jung, SH; Cook, JM; Lagoo, A; Reya, T
Published in: Cancer Cell
December 2007

A key characteristic of stem cells and cancer cells is their ability to self-renew. To test if Wnt signaling can regulate the self-renewal of both stem cells and cancer cells in the hematopoietic system, we developed mice that lack beta-catenin in their hematopoietic cells. Here we show that beta-catenin-deficient mice can form HSCs, but that these cells are deficient in long-term growth and maintenance. Moreover, beta-catenin deletion causes a profound reduction in the ability of mice to develop BCR-ABL-induced chronic myelogenous leukemia (CML), while allowing progression of acute lymphocytic leukemia (ALL). These studies demonstrate that Wnt signaling is required for the self-renewal of normal and neoplastic stem cells in the hematopoietic system.

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Published In

Cancer Cell

DOI

ISSN

1535-6108

Publication Date

December 2007

Volume

12

Issue

6

Start / End Page

528 / 541

Location

United States

Related Subject Headings

  • beta Catenin
  • Wnt Proteins
  • Stem Cell Transplantation
  • STAT5 Transcription Factor
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Phosphorylation
  • Oncology & Carcinogenesis
  • Neoplastic Stem Cells
  • Mice
  • Lung
 

Citation

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Zhao, C., Blum, J., Chen, A., Kwon, H. Y., Jung, S. H., Cook, J. M., … Reya, T. (2007). Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell, 12(6), 528–541. https://doi.org/10.1016/j.ccr.2007.11.003
Zhao, Chen, Jordan Blum, Alan Chen, Hyog Young Kwon, Seung Hye Jung, J Michael Cook, Anand Lagoo, and Tannishtha Reya. “Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo.Cancer Cell 12, no. 6 (December 2007): 528–41. https://doi.org/10.1016/j.ccr.2007.11.003.
Zhao C, Blum J, Chen A, Kwon HY, Jung SH, Cook JM, et al. Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell. 2007 Dec;12(6):528–41.
Zhao, Chen, et al. “Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo.Cancer Cell, vol. 12, no. 6, Dec. 2007, pp. 528–41. Pubmed, doi:10.1016/j.ccr.2007.11.003.
Zhao C, Blum J, Chen A, Kwon HY, Jung SH, Cook JM, Lagoo A, Reya T. Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell. 2007 Dec;12(6):528–541.
Journal cover image

Published In

Cancer Cell

DOI

ISSN

1535-6108

Publication Date

December 2007

Volume

12

Issue

6

Start / End Page

528 / 541

Location

United States

Related Subject Headings

  • beta Catenin
  • Wnt Proteins
  • Stem Cell Transplantation
  • STAT5 Transcription Factor
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Phosphorylation
  • Oncology & Carcinogenesis
  • Neoplastic Stem Cells
  • Mice
  • Lung