An exploratory analysis of the impact of family functioning on treatment for depression in adolescents.

Journal Article (Journal Article)

This article explores aspects of family environment and parent-child conflict that may predict or moderate response to acute treatments among depressed adolescents (N = 439) randomly assigned to fluoxetine, cognitive behavioral therapy, their combination, or placebo. Outcomes were Week 12 scores on measures of depression and global impairment. Of 20 candidate variables, one predictor emerged: Across treatments, adolescents with mothers who reported less parent-child conflict were more likely to benefit than their counterparts. When family functioning moderated outcome, adolescents who endorsed more negative environments were more likely to benefit from fluoxetine. Similarly, when moderating effects were seen on cognitive behavioral therapy conditions, they were in the direction of being less effective among teens reporting poorer family environments.

Full Text

Duke Authors

Cited Authors

  • Feeny, NC; Silva, SG; Reinecke, MA; McNulty, S; Findling, RL; Rohde, P; Curry, JF; Ginsburg, GS; Kratochvil, CJ; Pathak, SM; May, DE; Kennard, BD; Simons, AD; Wells, KC; Robins, M; Rosenberg, D; March, JS

Published Date

  • November 2009

Published In

Volume / Issue

  • 38 / 6

Start / End Page

  • 814 - 825

PubMed ID

  • 20183665

Pubmed Central ID

  • PMC3609662

Electronic International Standard Serial Number (EISSN)

  • 1537-4424

Digital Object Identifier (DOI)

  • 10.1080/15374410903297148


  • eng

Conference Location

  • England