Expression of E-selectin messenger RNA and protein in rheumatoid arthritis.

Journal Article (Journal Article)

OBJECTIVE: To examine the de novo synthesis and cellular distribution of the E-selectin adhesion molecule in synovial tissues obtained from patients with rheumatoid arthritis (RA). METHODS: Immunohistochemistry techniques combined with in situ hybridization were used to examine RA synovium. RESULTS: There were numerous endothelial cells positive for E-selectin and E-selectin messenger RNA in the RA synovial membranes. Moreover, E-selectin expression appeared to correlate with inflammatory activity. CONCLUSION: The strong vascular expression of E-selectin indicates an activation of endothelial cells in the recruitment of cells associated with the chronic inflammation of RA.

Full Text

Duke Authors

Cited Authors

  • Kriegsmann, J; Keyszer, GM; Geiler, T; Lagoo, AS; Lagoo-Deenadayalan, S; Gay, RE; Gay, S

Published Date

  • June 1995

Published In

Volume / Issue

  • 38 / 6

Start / End Page

  • 750 - 754

PubMed ID

  • 7540009

International Standard Serial Number (ISSN)

  • 0004-3591

Digital Object Identifier (DOI)

  • 10.1002/art.1780380606


  • eng

Conference Location

  • United States