Expression of E-selectin messenger RNA and protein in rheumatoid arthritis.
Publication
, Journal Article
Kriegsmann, J; Keyszer, GM; Geiler, T; Lagoo, AS; Lagoo-Deenadayalan, S; Gay, RE; Gay, S
Published in: Arthritis Rheum
June 1995
OBJECTIVE: To examine the de novo synthesis and cellular distribution of the E-selectin adhesion molecule in synovial tissues obtained from patients with rheumatoid arthritis (RA). METHODS: Immunohistochemistry techniques combined with in situ hybridization were used to examine RA synovium. RESULTS: There were numerous endothelial cells positive for E-selectin and E-selectin messenger RNA in the RA synovial membranes. Moreover, E-selectin expression appeared to correlate with inflammatory activity. CONCLUSION: The strong vascular expression of E-selectin indicates an activation of endothelial cells in the recruitment of cells associated with the chronic inflammation of RA.
Duke Scholars
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Published In
Arthritis Rheum
DOI
ISSN
0004-3591
Publication Date
June 1995
Volume
38
Issue
6
Start / End Page
750 / 754
Location
United States
Related Subject Headings
- Up-Regulation
- Synovial Membrane
- RNA, Messenger
- Molecular Sequence Data
- Middle Aged
- Male
- In Situ Hybridization
- Immunohistochemistry
- Humans
- Female
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MLA
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Kriegsmann, J., Keyszer, G. M., Geiler, T., Lagoo, A. S., Lagoo-Deenadayalan, S., Gay, R. E., & Gay, S. (1995). Expression of E-selectin messenger RNA and protein in rheumatoid arthritis. Arthritis Rheum, 38(6), 750–754. https://doi.org/10.1002/art.1780380606
Kriegsmann, J., G. M. Keyszer, T. Geiler, A. S. Lagoo, S. Lagoo-Deenadayalan, R. E. Gay, and S. Gay. “Expression of E-selectin messenger RNA and protein in rheumatoid arthritis.” Arthritis Rheum 38, no. 6 (June 1995): 750–54. https://doi.org/10.1002/art.1780380606.
Kriegsmann J, Keyszer GM, Geiler T, Lagoo AS, Lagoo-Deenadayalan S, Gay RE, et al. Expression of E-selectin messenger RNA and protein in rheumatoid arthritis. Arthritis Rheum. 1995 Jun;38(6):750–4.
Kriegsmann, J., et al. “Expression of E-selectin messenger RNA and protein in rheumatoid arthritis.” Arthritis Rheum, vol. 38, no. 6, June 1995, pp. 750–54. Pubmed, doi:10.1002/art.1780380606.
Kriegsmann J, Keyszer GM, Geiler T, Lagoo AS, Lagoo-Deenadayalan S, Gay RE, Gay S. Expression of E-selectin messenger RNA and protein in rheumatoid arthritis. Arthritis Rheum. 1995 Jun;38(6):750–754.
Published In
Arthritis Rheum
DOI
ISSN
0004-3591
Publication Date
June 1995
Volume
38
Issue
6
Start / End Page
750 / 754
Location
United States
Related Subject Headings
- Up-Regulation
- Synovial Membrane
- RNA, Messenger
- Molecular Sequence Data
- Middle Aged
- Male
- In Situ Hybridization
- Immunohistochemistry
- Humans
- Female