Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Research Assistant Professor, Surgery, University of Alabama at Birmingham 1992 - 1993
  • Transplantation Fellow, Surgery, University of Alabama at Birmingham 1990 - 1992
  • Ph.D., University of Texas Health Science Center San Antonio 1990
  • M.D., B.J. Medical College, Gujarat University (India) 1985
• 

  Duke Appointment History

  • Associate Professor of Surgery, Surgical Oncology, Surgery 2011
  • Associate Professor of Surgery, Surgery, Clinical Science Departments 2009 - 2011
  • Assistant Professor of Surgery, Surgery, Clinical Science Departments 2002 - 2009
  • Instructor, Temporary in the Department of Surgery, Surgery, Clinical Science Departments 2002
• Research
• 

  Selected Grants

  • Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative awarded by National Institutes of Health 2017 - 2019
  • Educating Anesthesia Residents to Improve Perioperative Care for the Elderly awarded by American Geriatrics Society 2015 - 2017
  • Aging and Immune Response in Sepsis awarded by National Institutes of Health 2007 - 2010
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Corey, KM, Kashyap, S, Lorenzi, E, Lagoo-Deenadayalan, SA, Heller, K, Whalen, K, Balu, S, Heflin, MT, McDonald, SR, Swaminathan, M, and Sendak, M. "Development and validation of machine learning models to identify high-risk surgical patients using automatically curated electronic health record data (Pythia): A retrospective, single-site study." Plos Medicine 15, no. 11 (November 27, 2018): e1002701-null.  Full Text
    • Berian, JR, Baker, TL, Rosenthal, RA, Coleman, J, Finlayson, E, Katlic, MR, Lagoo-Deenadayalan, SA, Tang, VL, Robinson, TN, Ko, CY, and Russell, MM. "Application of the RAND-UCLA Appropriateness Methodology to a Large Multidisciplinary Stakeholder Group Evaluating the Validity and Feasibility of Patient-Centered Standards in Geriatric Surgery." Health Services Research 53, no. 5 (October 2018): 3350-3372.  Full Text
    • Zietlow, K, McDonald, SR, Sloane, R, Browndyke, J, Lagoo-Deenadayalan, S, and Heflin, MT. "Preoperative Cognitive Impairment As a Predictor of Postoperative Outcomes in a Collaborative Care Model." Journal of the American Geriatrics Society 66, no. 3 (March 2018): 584-589.  Full Text  Open Access Copy
    • Berian, JR, Rosenthal, RA, Baker, TL, Coleman, J, Finlayson, E, Katlic, MR, Lagoo-Deenadayalan, SA, Tang, VL, Robinson, TN, Ko, CY, and Russell, MM. "Hospital Standards to Promote Optimal Surgical Care of the Older Adult: A Report From the Coalition for Quality in Geriatric Surgery." Annals of Surgery 267, no. 2 (February 2018): 280-290.  Full Text
    • McDonald, SR, Heflin, MT, Whitson, HE, Dalton, TO, Lidsky, ME, Liu, P, Poer, CM, Sloane, R, Thacker, JK, White, HK, Yanamadala, M, and Lagoo-Deenadayalan, SA. "Association of Integrated Care Coordination With Postsurgical Outcomes in High-Risk Older Adults: The Perioperative Optimization of Senior Health (POSH) Initiative." JAMA surgery (January 3, 2018).  Full Text
    • Giattino, CM, Gardner, JE, Sbahi, FM, Roberts, KC, Cooter, M, Moretti, E, Browndyke, JN, Mathew, JP, Woldorff, MG, Berger, M, and MADCO-PC Investigators, . "Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults." Frontiers in Systems Neuroscience 11 (January 2017): 24-null.  Full Text  Open Access Copy
    • Belle, JM, Bang, RA, Kelkar, D, Østbye, T, and Lagoo-Deenadayalan, SA. "Innovative bridging of the rural-urban divide: comparison of scope, safety, and impact of collaborative rural surgery camps and an urban surgical program." World journal of surgery 39, no. 4 (April 2015): 871-878.  Full Text
    • Scarborough, JE, Bennett, KM, Englum, BR, Pappas, TN, and Lagoo-Deenadayalan, SA. "The impact of functional dependency on outcomes after complex general and vascular surgery." Annals of Surgery 261, no. 3 (March 2015): 432-437.  Full Text
    • Barbas, AS, Haney, JC, Henry, BV, Heflin, MT, and Lagoo, SA. "Development and implementation of a formalized geriatric surgery curriculum for general surgery residents." Gerontology & geriatrics education 35, no. 4 (January 2014): 380-394.  Full Text
    • Gan, TJ, Diemunsch, P, Habib, AS, Kovac, A, Kranke, P, Meyer, TA, Watcha, M, Chung, F, Angus, S, Apfel, CC, Bergese, SD, Candiotti, KA, Chan, MT, Davis, PJ, Hooper, VD, Lagoo-Deenadayalan, S, Myles, P, Nezat, G, Philip, BK, Tramèr, MR, and Society for Ambulatory Anesthesia, . "Consensus guidelines for the management of postoperative nausea and vomiting." Anesthesia and Analgesia 118, no. 1 (January 2014): 85-113.  Full Text
    • Speicher, PJ, Lagoo-Deenadayalan, SA, Galanos, AN, Pappas, TN, and Scarborough, JE. "Expectations and outcomes in geriatric patients with do-not-resuscitate orders undergoing emergency surgical management of bowel obstruction." Jama Surg 148, no. 1 (January 2013): 23-28.  Full Text  Link to Item
    • Cohen, R-R, Lagoo-Deenadayalan, SA, Heflin, MT, Sloane, R, Eisen, I, Thacker, JM, and Whitson, HE. "Exploring predictors of complication in older surgical patients: a deficit accumulation index and the Braden Scale." J Am Geriatr Soc 60, no. 9 (September 2012): 1609-1615.  Full Text  Link to Item
    • Lidsky, ME, Thacker, JKM, Lagoo-Deenadayalan, SA, and Scarborough, JE. "Advanced age is an independent predictor for increased morbidity and mortality after emergent surgery for diverticulitis." Surgery 152, no. 3 (September 2012): 465-472.  Full Text  Link to Item
    • Scarborough, JE, Pappas, TN, Bennett, KM, and Lagoo-Deenadayalan, S. "Failure-to-pursue rescue: explaining excess mortality in elderly emergency general surgical patients with preexisting "do-not-resuscitate" orders." Ann Surg 256, no. 3 (September 2012): 453-461.  Full Text  Link to Item
    • Barbas, AS, Turley, RS, Ceppa, EP, Reddy, SK, Blazer, DG, Clary, BM, Pappas, TN, Tyler, DS, White, RR, and Lagoo, SA. "Comparison of outcomes and the use of multimodality therapy in young and elderly people undergoing surgical resection of pancreatic cancer." J Am Geriatr Soc 60, no. 2 (February 2012): 344-350.  Full Text  Link to Item
    • Zenilman, ME, Chow, WB, Ko, CY, Ibrahim, AM, Makary, MA, Lagoo-Deenadayalan, S, Dardik, A, Boyd, CA, Riall, TS, Sosa, JA, Tummel, E, Gould, LJ, Segev, DL, and Berger, JC. "New developments in geriatric surgery." Current Problems in Surgery 48, no. 10 (October 2011): 670-754.  Full Text
    • Hadeed, JG, Walsh, MD, Pappas, TN, Pestana, IA, Tyler, DS, Levinson, H, Mantyh, C, Jacobs, DO, Lagoo-Deenadalayan, SA, and Erdmann, D. "Complex abdominal wall hernias: a new classification system and approach to management based on review of 133 consecutive patients." Ann Plast Surg 66, no. 5 (May 2011): 497-503.  Full Text  Link to Item
    • Reddy, SK, Barbas, AS, Turley, RS, Gamblin, TC, Geller, DA, Marsh, JW, Tsung, A, Clary, BM, and Lagoo-Deenadayalan, S. "Major liver resection in elderly patients: a multi-institutional analysis." J Am Coll Surg 212, no. 5 (May 2011): 787-795.  Full Text  Link to Item
    • Pan, H, Ding, E, Hu, M, Lagoo, AS, Datto, MB, and Lagoo-Deenadayalan, SA. "SMAD4 is required for development of maximal endotoxin tolerance." J Immunol 184, no. 10 (May 15, 2010): 5502-5509.  Full Text  Link to Item
    • Li, Y, Howell, EA, Lagoo, AS, Kuchibhatla, M, Pan, H, Cohen, HJ, and Lagoo, SA. "Differential gene expression of interleukin-1 receptor associated kinase-1 and interleukin-1 receptor associated kinase-M in peripheral blood mononuclear cells of young and aged rats following preconditioning with endotoxin." Shock 31, no. 1 (January 2009): 55-63.  Full Text  Link to Item
    • Clary, EM, Manson, RJ, Lagoo, S, Pappas, TN, and Eubanks, S. "Percutaneous cervical oesophageal cannulation in the dog for the performance of prolonged oesophageal pH and manometric studies." Laboratory Animals 39, no. 4 (October 2005): 435-441.  Full Text
    • Ali, NA, Eubanks, WS, Stamler, JS, Gow, AJ, Lagoo-Deenadayalan, SA, Villegas, L, El-Moalem, HE, and Reynolds, JD. "A method to attenuate pneumoperitoneum-induced reductions in splanchnic blood flow." Ann Surg 241, no. 2 (February 2005): 256-261.  Link to Item
    • Kalady, MF, McKinlay, R, Jr, JAO, Pinheiro, J, Lagoo, S, Park, A, and Eubanks, WS. "Laparoscopic adrenalectomy for pheochromocytoma: A comparison to aldosteronoma and incidentaloma." Surgical Endoscopy and Other Interventional Techniques 18, no. 4 (2004): 621-625.  Full Text
    • Lagoo-Deenadayalan, S, and Eubanks, WS. "Palliative bypass procedures." Operative Techniques in General Surgery 6, no. 1 (January 1, 2004): 13-22.  Full Text
    • Villegas, L, Lagoo, S, Schwartz, T, Athar, N, Greene, R, and Eubanks, WS. "Robotically assisted laparoscopic Roux-en-Y hepaticojejunostomy." JSLS : Journal of the Society of Laparoendoscopic Surgeons / Society of Laparoendoscopic Surgeons 8, no. 3 (2004): 239-244.
    • Lagoo, S, McMahon, RL, Kakihara, M, Pappas, TN, and Eubanks, S. "The sixth decision regarding perforated duodenal ulcer." Jsls : Journal of the Society of Laparoendoscopic Surgeons 6, no. 4 (October 2002): 359-368. (Review)
    • Bennett, WA, Lagoo-Deenadayalan, S, Whitworth, NS, Stopple, JA, Barber, WH, Hale, E, Brackin, MN, and Cowan, BD. "First-trimester human chorionic villi express both immunoregulatory and inflammatory cytokines: A role for interleukin-10 in regulating the cytokine network of pregnancy." American Journal of Reproductive Immunology 41, no. 1 (1999): 70-78.
    • Rinehart, BK, Terrone, DA, Lagoo-Deenadayalan, S, Barber, WH, Hale, EA, Jr, JNM, and Bennett, WA. "Expression of the placental cytokines tumor necrosis factor α, interleukin 1β, and interleukin 10 is increased in preeclampsia." American Journal of Obstetrics and Gynecology 181, no. 4 (1999): 915-920.  Full Text
    • Lorenz, HM, Lagoo, AS, Lagoo-Deenadalayan, SA, Barber, WH, Kalden, JR, and Hardy, KJ. "Epitope-specific signaling through CD45 on T lymphocytes leads to cAMP synthesis in monocytes after ICAM-1-dependent cellular interaction." European Journal of Immunology 28, no. 8 (August 1998): 2300-2310.  Full Text
    • Bennett, WA, Lagoo-Deenadayalan, S, Stopple, JA, Barber, WH, Hale, E, Brackin, MN, and Cowan, BD. "Cytokine expression by first-trimester human chorionic villi." American Journal of Reproductive Immunology 40, no. 5 (1998): 309-318.
    • Bennett, WA, Lagoo-Deenadayalan, S, Whitworth, NS, Brackin, MN, Hale, E, and Cowan, BD. "Expression and production of interleukin-10 by human trophoblast: relationship to pregnancy immunotolerance." Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy 3, no. 3 (1997): 190-198.
    • Chakravarti, B, Lagoo-Deenadayalan, S, Parker, JS, Whitfield, DR, Lagoo, A, and Chakravarti, DN. "In vivo molecular analysis of cytokines in a murine model of ocular onchocerciasis. I. Up-regulation of IL-4 and IL-5 mRNAs and not IL-2 and IFN gamma mRNAs in the cornea due to experimental interstitial keratitis." Immunol Lett 54, no. 1 (December 1, 1996): 59-64.  Link to Item
    • Lagoo, AS, George, JF, Naftel, DC, Griffin, AK, Kirklin, JK, Lagoo-Deenadayalan, S, Hardy, KJ, Savunen, T, and McGiffin, DC. "Semiquantitative measurement of cytokine messenger RNA in endomyocardium and peripheral blood mononuclear cells from human heart transplant recipients." J Heart Lung Transplant 15, no. 2 (February 1996): 206-217.  Link to Item
    • Bennett, WA, Lagoo-Deenadayalan, S, Brackin, MN, Hale, E, and Cowan, BD. "Cytokine expression by models of human trophoblast as assessed by a semiquantitative reverse transcription-polymerase chain reaction technique." American Journal of Reproductive Immunology 36, no. 5 (1996): 285-294.
    • Lagoo-Deenadayalan, S, Lagoo, AS, Lemons, JA, Lorenz, HM, Bass, JD, McDaniel, DO, Hardy, KJ, and Barber, WH. "Donor-specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate TH1 and TH2 cytokine gene expression in the responder cell population." Adv Nephrol Necker Hosp 25 (1996): 107-127.  Link to Item
    • Salahudeen, A, Wang, C, McDaniel, O, Lagoo-Denadyalan, S, Bigler, S, and Barber, H. "Antioxidant lazaroid U-74006F improves renal function and reduces the expression of cytokines, inducible nitric oxide synthase, and MHC antigens in a syngeneic renal transplant model: Partial support for the response-to- injury hypothesis." Transplantation 62, no. 11 (1996): 1628-1633.  Full Text
    • Hauser, CJ, Lagoo, S, Lagoo, A, Hale, E, Hardy, KJ, Barber, WH, Bass, JD, and Poole, GV. "Tumor necrosis factor alpha gene expression in human peritoneal macrophages is suppressed by extra-abdominal trauma." Arch Surg 130, no. 11 (November 1995): 1186-1191.  Link to Item
    • Hauser, CJ, Lagoo, S, Lagoo, A, Hale, E, Hardy, KJ, Barber, WH, Bass, JD, and Poole, GV. "Human peripheral mononuclear cells do not show proinflammatory patterns of cytokine transcription in early trauma: a preliminary report." Shock 4, no. 4 (October 1995): 247-250.  Link to Item
    • Beagley, KW, Fujihashi, K, Lagoo, AS, Lagoo-Deenadaylan, S, Black, CA, Murray, AM, Sharmanov, AT, Yamamoto, M, McGhee, JR, and Elson, CO. "Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine." J Immunol 154, no. 11 (June 1, 1995): 5611-5619.  Link to Item
    • Kriegsmann, J, Keyszer, GM, Geiler, T, Lagoo, AS, Lagoo-Deenadayalan, S, Gay, RE, and Gay, S. "Expression of E-selectin messenger RNA and protein in rheumatoid arthritis." Arthritis Rheum 38, no. 6 (June 1995): 750-754.  Link to Item
    • Lagoo-Deenadayalan, S, Lagoo, AS, Lemons, JA, Lorenz, HM, Bass, JD, McDaniel, DO, Hardy, KJ, and Barber, WH. "Donor specific bone marrow cells suppress lymphocyte reactivity to donor antigens and differentially modulate TH1 and TH2 cytokine gene expression in the responder cell population." Transpl Immunol 3, no. 2 (June 1995): 124-134.  Link to Item
    • Lagoo, AS, Eldridge, JH, Lagoo-Deenadaylan, S, Black, CA, Ridwan, BU, Hardy, KJ, McGhee, JR, and Beagley, KW. "Peyer's patch CD8+ memory T cells secrete T helper type 1 and type 2 cytokines and provide help for immunoglobulin secretion." Eur J Immunol 24, no. 12 (December 1994): 3087-3092.  Full Text  Link to Item
    • Lagoo, AS, Lagoo-Deenadayalan, S, Lorenz, HM, Byrne, J, Barber, WH, and Hardy, KJ. "IL-2, IL-4, and IFN-gamma gene expression versus secretion in superantigen-activated T cells. Distinct requirement for costimulatory signals through adhesion molecules." J Immunol 152, no. 4 (February 15, 1994): 1641-1652.  Link to Item
    • McDaniel, DO, Naftilan, J, Hulvey, K, Shaneyfelt, S, Lemons, JA, Lagoo-Deenadayalan, S, Hudson, S, Diethelm, AG, and Barber, WH. "Peripheral blood chimerism in renal allograft recipients transfused with donor bone marrow." Transplantation 57, no. 6 (1994): 852-856.
    • Lagoo-Deenadayalan, S, Lagoo, AS, Barber, WH, and Hardy, KJ. "A standardized approach to PCR-based semiquantitation of multiple cytokine gene transcripts from small cell samples." Lymphokine Cytokine Res 12, no. 2 (April 1993): 59-67.  Link to Item
    • Lagoo-Deenadayalan, S, Lagoo, AS, Hardy, KJ, and Grimm, EA. "Tumor recognition and lytic competence of IL-2-activated lymphocytes: regulation of both antibody-independent and -dependent cellular cytotoxicity via P75 IL-2 receptor." Lymphokine Cytokine Res 11, no. 4 (August 1992): 207-213.  Link to Item
    • Grimm, EA, III, WLC, Durett, A, Hester, JP, Lagoo-Deenadalayan, S, and Owen-Schaub, LB. "TGF-Beta inhibits the in vitro induction of lymphokine-activated killing activity." Cancer Immunology Immunotherapy 27, no. 1 (1988): 53-58.  Full Text

  • Book Sections

    • Lagoo, JA, and Lagoo-Deenadayalan, SA. "The importance of contextual relevance and cultural appropriateness in global surgery." In Global Surgery: The Essentials, 147-161. May 2, 2017.  Full Text
    • Mallipeddi, MK, and Lagoo-Deenadayalan, SA. "Urgent workup for upper gastrointestinal bleeding." In Gastrointestinal Bleeding: A Practical Approach to Diagnosis and Management, Second Edition, 15-26. January 1, 2016.  Full Text
    • Speicher, P, and Lagoo-Deenadayalan, S. "The Approach to Reoperations in the Geriatric Population." In Reoperative Abdominal Surgery. : JP Medical Ltd, July 21, 2014. (Chapter)
    • Ganapathi, A, and Lagoo-Deenadayalan, SA. "Biliary anatomy." In Contemporary Surgical Management of Liver, Biliary Tract, and Pancreatic Disease, 253-262. January 1, 2013.  Full Text
    • Williams, JB, and Lagoo-Deenadayalan, SA. "Benign gallbladder disease: Postcholecystectomy syndrome and stricture." In Contemporary Surgical Management of Liver, Biliary Tract, and Pancreatic Disease, 305-310. January 1, 2013.  Full Text
    • Erhunmwunsee, L, and Lagoo-Deenadayalan, SA. "Urgent workup for upper gastrointestinal bleeding." In Gastrointestinal Bleeding: A Practical Approach to Diagnosis and Management, 13-22. December 1, 2010.  Full Text

  • Other Articles

    • Scarborough, JE, Pappas, TN, Bennett, KM, and Lagoo-Deenadayalan, SA. "Reply to Letter: "Failure-to-pursue Rescue: Truly a Failure?"." Annals of surgery 262, no. 2 (August 2015): e44-. (Letter)  Full Text
    • Zenilman, ME, Chow, WB, Ko, CY, Ibrahim, AM, Makary, MA, Lagoo-Deenadayalan, S, Dardik, A, Boyd, CA, Riall, TS, Sosa, JA, Tummel, E, Gould, LJ, Segev, DL, and Berger, JC. "In Brief." Current Problems in Surgery 48, no. 10 (October 1, 2011): 665-666.  Full Text
    • Lagoo, SA, and Pappas, TN. "Laparoscopic repair for perforated peptic ulcer." Ann Surg 235, no. 3 (March 2002): 320-321.  Link to Item
    • Wang, C, Hale, E, Lagoo-Deenadayalan, S, Barber, H, and Salahudeen, A. "Inhibition of lipid peroxidation down regulates inflammatory cytokines and inducible nitric oxide synthase (iNOS) in cold-preserved syngenic transplanted rat kidneys along with functional protection." Journal of Investigative Medicine 44, no. 1 (January 1, 1996).
    • Wang, C, Own, R, Bigler, S, Lagoo, S, Barber, H, and Salahudeen, A. "Effect of antioxidants on the renal expression of cytokines, inos, adhesion molecules and mhc antigens in a syngeneic renal transplant model: Testing the "response-to-injury" hypothesis." Journal of Investigative Medicine 44, no. 3 (January 1, 1996).

  • Conference Papers

    • Scarborough, JE, Lagoo-Deenadayalan, SA, Pappas, TN, Bennett, KM, and Shortell, CK. "PS70. Patient Age is an Independent Predictor of Mortality After Emergency Vascular Surgery." : Elsevier BV, June 2014.  Full Text
    • Petersen, RP, Heflin, MT, Groban, L, and Lagoo-Deenadayalan, SA. "Surgery Residents Desire more Training in Geriatric Care." March 2009.  Link to Item
    • Li, Y, Howell, A, Cohen, HJ, and Lagoo-Deenadayalan, SA. "Post-translational modification of IRAK-1 mRNA in PBMCs from aged rats." April 2006.  Link to Item
    • Burch, LH, Yang, IV, Dressman, HK, Schwartz, DA, Guo, H, Kuo, PC, Cohen, HJ, and Lagoo-Deenadayalan, SA. "Transcriptional response to endotoxin in young adult and aged rats." Annual Meeting of the American-Geriatrics-Society. Orlando, FL. May 11, 2005 - May 15, 2005.: WILEY-BLACKWELL, April 1, 2005.  Link to Item
    • Nathan, JD, Frankel, B, Jaben, K, Reynolds, JD, Manson, RJ, Pappas, TN, Eubanks, WS, and Lagoo-Deenadayalan, SA. "Nissen versus Toupet fundoplication in the management of gastroesophageal reflux disease." April 2005.  Link to Item

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