AID expression during B-cell development: searching for answers.
Journal Article (Journal Article)
Expression of activation-induced cytidine deaminase (AID) by germinal center (GC) B cells drives the processes of immunoglobulin (Ig) somatic hypermutation (SHM) and class switch recombination (CSR) necessary for the generation of high affinity IgG serum antibody and the memory B-cell compartment. Increasing evidence indicates that AID is also expressed at low levels in developing B cells but to date, this early, developmentally regulated AID expression has no known function. Does the timing and extent of AID expression in developmentally immature, non-GC B cells provide clues to reveal its physiologic role?
Full Text
Duke Authors
Cited Authors
- Kuraoka, M; McWilliams, L; Kelsoe, G
Published Date
- April 2011
Published In
Volume / Issue
- 49 / 1-3
Start / End Page
- 3 - 13
PubMed ID
- 21136202
Electronic International Standard Serial Number (EISSN)
- 1559-0755
Digital Object Identifier (DOI)
- 10.1007/s12026-010-8185-7
Language
- eng
Conference Location
- United States