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AID expression during B-cell development: searching for answers.

Publication ,  Journal Article
Kuraoka, M; McWilliams, L; Kelsoe, G
Published in: Immunol Res
April 2011

Expression of activation-induced cytidine deaminase (AID) by germinal center (GC) B cells drives the processes of immunoglobulin (Ig) somatic hypermutation (SHM) and class switch recombination (CSR) necessary for the generation of high affinity IgG serum antibody and the memory B-cell compartment. Increasing evidence indicates that AID is also expressed at low levels in developing B cells but to date, this early, developmentally regulated AID expression has no known function. Does the timing and extent of AID expression in developmentally immature, non-GC B cells provide clues to reveal its physiologic role?

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Published In

Immunol Res

DOI

EISSN

1559-0755

Publication Date

April 2011

Volume

49

Issue

1-3

Start / End Page

3 / 13

Location

United States

Related Subject Headings

  • Somatic Hypermutation, Immunoglobulin
  • Recombination, Genetic
  • Mice
  • Immunology
  • Immunoglobulin G
  • Immunoglobulin Class Switching
  • Humans
  • Germinal Center
  • Gene Expression
  • Cytidine Deaminase
 

Citation

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Kuraoka, M., McWilliams, L., & Kelsoe, G. (2011). AID expression during B-cell development: searching for answers. Immunol Res, 49(1–3), 3–13. https://doi.org/10.1007/s12026-010-8185-7
Kuraoka, Masayuki, Laurie McWilliams, and Garnett Kelsoe. “AID expression during B-cell development: searching for answers.Immunol Res 49, no. 1–3 (April 2011): 3–13. https://doi.org/10.1007/s12026-010-8185-7.
Kuraoka M, McWilliams L, Kelsoe G. AID expression during B-cell development: searching for answers. Immunol Res. 2011 Apr;49(1–3):3–13.
Kuraoka, Masayuki, et al. “AID expression during B-cell development: searching for answers.Immunol Res, vol. 49, no. 1–3, Apr. 2011, pp. 3–13. Pubmed, doi:10.1007/s12026-010-8185-7.
Kuraoka M, McWilliams L, Kelsoe G. AID expression during B-cell development: searching for answers. Immunol Res. 2011 Apr;49(1–3):3–13.
Journal cover image

Published In

Immunol Res

DOI

EISSN

1559-0755

Publication Date

April 2011

Volume

49

Issue

1-3

Start / End Page

3 / 13

Location

United States

Related Subject Headings

  • Somatic Hypermutation, Immunoglobulin
  • Recombination, Genetic
  • Mice
  • Immunology
  • Immunoglobulin G
  • Immunoglobulin Class Switching
  • Humans
  • Germinal Center
  • Gene Expression
  • Cytidine Deaminase