Apoptotic force and tissue dynamics during Drosophila embryogenesis.

Journal Article (Journal Article)

Understanding cell morphogenesis during metazoan development requires knowledge of how cells and the extracellular matrix produce and respond to forces. We investigated how apoptosis, which remodels tissue by eliminating supernumerary cells, also contributes forces to a tissue (the amnioserosa) that promotes cell-sheet fusion (dorsal closure) in the Drosophila embryo. We showed that expression in the amnioserosa of proteins that suppress or enhance apoptosis slows or speeds dorsal closure, respectively. These changes correlate with the forces produced by the amnioserosa and the rate of seam formation between the cell sheets (zipping), key processes that contribute to closure. This apoptotic force is used by the embryo to drive cell-sheet movements during development, a role not classically attributed to apoptosis.

Full Text

Duke Authors

Cited Authors

  • Toyama, Y; Peralta, XG; Wells, AR; Kiehart, DP; Edwards, GS

Published Date

  • September 2008

Published In

Volume / Issue

  • 321 / 5896

Start / End Page

  • 1683 - 1686

PubMed ID

  • 18802000

Pubmed Central ID

  • PMC2757114

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1157052


  • eng