Overview
Glenn Edwards investigates biological systems using a range of experimental techniques and theoretical methods from physics. His interests include Investigations of energy transduction where laser energy transforms into vibrational energy of biological molecules which then transforms into heat and pressure pulses that selectively drive tissue-scale dynamics. This line of research has led to human surgical applications of Free-Electron Lasers and spin-off laser technology. Another interest includes investigations of how biology harnesses physical mechanisms in biomechanical processes. This line of research investigates tissue dynamics and pattern formation during early development in Drosophila embryos.
Current Appointments & Affiliations
Professor Emeritus of Physics
·
2024 - Present
Physics,
Trinity College of Arts & Sciences
Recent Publications
Mathematical models of dorsal closure.
Journal Article Progress in biophysics and molecular biology · September 2018 Dorsal closure is a model cell sheet movement that occurs midway through Drosophila embryogenesis. A dorsal hole, filled with amnioserosa, closes through the dorsalward elongation of lateral epidermal cell sheets. Closure requires contributions from 5 dist ... Full text CiteUnified biophysical mechanism for cell-shape oscillations and cell ingression.
Journal Article Physical review. E · June 2018 We describe a mechanochemical and percolation cascade that augments myosin's regulatory network to tune cytoskeletal forces. Actomyosin forces collectively generate cytoskeletal forces during cell oscillations and ingression, which we quantify by elastic p ... Full text CiteCell Sheet Morphogenesis: Dorsal Closure in Drosophila melanogaster as a Model System.
Journal Article Annual review of cell and developmental biology · October 2017 Dorsal closure is a key process during Drosophila morphogenesis that models cell sheet movements in chordates, including neural tube closure, palate formation, and wound healing. Closure occurs midway through embryogenesis and entails circumferential elong ... Full text CiteRecent Grants
Morphogenesis: Biophysics and Genetics of Dorsal Closure
ResearchCo Investigator · Awarded by National Institutes of Health · 1984 - 2018Complex Networks: Structure and Function of Large-Scale Neural Networks
ResearchPrincipal Investigator · Awarded by Army Research Office · 2012 - 2015Structural Biology and Biophysics Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2015View All Grants
Education, Training & Certifications
University of Maryland, College Park ·
1984
Ph.D.
University of Maryland, College Park ·
1978
B.S.