Biology and functions of the RGS9 isoforms.


Book Section

Two splice isoforms of the ninth member of the regulator of G protein signaling (RGS) protein family are expressed in the nervous system, where they are engaged in such diverse functions as vision and behavior. RGS9-1 regulates phototransduction in rods and cones, while RGS9-2 regulates dopamine and opioid signaling in the basal ganglia. The main goal of this review is to illustrate how these functions are fulfilled through the interplay between the intrinsic molecular properties of RGS9 isoforms and their interactions with several key protein partners in the cells in which they are expressed.

Full Text

Duke Authors

Cited Authors

  • Martemyanov, KA; Arshavsky, VY

Published Date

  • 2009

Volume / Issue

  • 86 /

Start / End Page

  • 205 - 227

PubMed ID

  • 20374717

Pubmed Central ID

  • 20374717

Digital Object Identifier (DOI)

  • 10.1016/S1877-1173(09)86007-9