Zinc and immunocompetence in elderly people: effects of zinc supplementation for 3 months.

Journal Article (Clinical Trial;Journal Article)

One hundred and three apparently healthy elderly subjects age 60-89 y were randomly assigned to one of three treatments: placebo, 15 mg zinc/d, or 100 mg Zn/d for 3 mo. Plasma Zn was significantly increased only in the 100 mg Zn group. Zn concentrations in erythrocytes, platelets, mononuclear cells, and polymorphonuclear leukocytes were not significantly increased by any treatment. None of the treatments significantly altered delayed dermal hypersensitivity (DDH) to a panel of seven recall antigens or in vitro lymphocyte proliferative responses (LPR) to mitogens and antigens. Fifteen subjects had initially poor lymphocyte proliferative responses that improved in 14 of these individuals during the study; this was not due to Zn supplementation but might have been caused by one or more components of a vitamin-mineral supplement administered to all study subjects.

Full Text

Duke Authors

Cited Authors

  • Bogden, JD; Oleske, JM; Lavenhar, MA; Munves, EM; Kemp, FW; Bruening, KS; Holding, KJ; Denny, TN; Guarino, MA; Krieger, LM

Published Date

  • September 1988

Published In

Volume / Issue

  • 48 / 3

Start / End Page

  • 655 - 663

PubMed ID

  • 3414581

International Standard Serial Number (ISSN)

  • 0002-9165

Digital Object Identifier (DOI)

  • 10.1093/ajcn/48.3.655


  • eng

Conference Location

  • United States