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Zinc and immunocompetence in elderly people: effects of zinc supplementation for 3 months.

Publication ,  Journal Article
Bogden, JD; Oleske, JM; Lavenhar, MA; Munves, EM; Kemp, FW; Bruening, KS; Holding, KJ; Denny, TN; Guarino, MA; Krieger, LM
Published in: Am J Clin Nutr
September 1988

One hundred and three apparently healthy elderly subjects age 60-89 y were randomly assigned to one of three treatments: placebo, 15 mg zinc/d, or 100 mg Zn/d for 3 mo. Plasma Zn was significantly increased only in the 100 mg Zn group. Zn concentrations in erythrocytes, platelets, mononuclear cells, and polymorphonuclear leukocytes were not significantly increased by any treatment. None of the treatments significantly altered delayed dermal hypersensitivity (DDH) to a panel of seven recall antigens or in vitro lymphocyte proliferative responses (LPR) to mitogens and antigens. Fifteen subjects had initially poor lymphocyte proliferative responses that improved in 14 of these individuals during the study; this was not due to Zn supplementation but might have been caused by one or more components of a vitamin-mineral supplement administered to all study subjects.

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Published In

Am J Clin Nutr

DOI

ISSN

0002-9165

Publication Date

September 1988

Volume

48

Issue

3

Start / End Page

655 / 663

Location

United States

Related Subject Headings

  • Zinc
  • Regression Analysis
  • Nutrition & Dietetics
  • Neutrophils
  • Mitogens
  • Middle Aged
  • Male
  • Lymphocyte Activation
  • Immunity
  • Hypersensitivity, Delayed
 

Citation

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Bogden, J. D., Oleske, J. M., Lavenhar, M. A., Munves, E. M., Kemp, F. W., Bruening, K. S., … Krieger, L. M. (1988). Zinc and immunocompetence in elderly people: effects of zinc supplementation for 3 months. Am J Clin Nutr, 48(3), 655–663. https://doi.org/10.1093/ajcn/48.3.655
Bogden, J. D., J. M. Oleske, M. A. Lavenhar, E. M. Munves, F. W. Kemp, K. S. Bruening, K. J. Holding, T. N. Denny, M. A. Guarino, and L. M. Krieger. “Zinc and immunocompetence in elderly people: effects of zinc supplementation for 3 months.Am J Clin Nutr 48, no. 3 (September 1988): 655–63. https://doi.org/10.1093/ajcn/48.3.655.
Bogden JD, Oleske JM, Lavenhar MA, Munves EM, Kemp FW, Bruening KS, et al. Zinc and immunocompetence in elderly people: effects of zinc supplementation for 3 months. Am J Clin Nutr. 1988 Sep;48(3):655–63.
Bogden, J. D., et al. “Zinc and immunocompetence in elderly people: effects of zinc supplementation for 3 months.Am J Clin Nutr, vol. 48, no. 3, Sept. 1988, pp. 655–63. Pubmed, doi:10.1093/ajcn/48.3.655.
Bogden JD, Oleske JM, Lavenhar MA, Munves EM, Kemp FW, Bruening KS, Holding KJ, Denny TN, Guarino MA, Krieger LM. Zinc and immunocompetence in elderly people: effects of zinc supplementation for 3 months. Am J Clin Nutr. 1988 Sep;48(3):655–663.

Published In

Am J Clin Nutr

DOI

ISSN

0002-9165

Publication Date

September 1988

Volume

48

Issue

3

Start / End Page

655 / 663

Location

United States

Related Subject Headings

  • Zinc
  • Regression Analysis
  • Nutrition & Dietetics
  • Neutrophils
  • Mitogens
  • Middle Aged
  • Male
  • Lymphocyte Activation
  • Immunity
  • Hypersensitivity, Delayed