Effect of vinblastine on rat liver ultrastructure.

Journal Article (Journal Article)

A single injection of vinblastine given i.v. to rats lead to the disappearance of microtubules, development of crystalline inclusions, dilation of Golgi sacculi, formation of multivesicular bodies and cytosegresomes as well as accumulation of lysosomes in the cytoplasm of liver cells. The endoplasmic reticulum and mitochondria do not seem to be affected. The question of whether or not these fine structural alterations are causally related has yet to be elucidated.

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Duke Authors

Dzau, Victor J.

Cited Authors

Kovacs, K; Horvath, E; Szabo, S; Dzau, VJ; Reynolds, ES

Published Date

1977

Published In

Arzneimittelforschung

Volume / Issue

27 / 4

Start / End Page

825 - 828

PubMed ID

194606

International Standard Serial Number (ISSN)

0004-4172

Language

Conference Location

Germany