Skip to main content
Journal cover image

Effect of vinblastine on rat liver ultrastructure.

Publication ,  Journal Article
Kovacs, K; Horvath, E; Szabo, S; Dzau, VJ; Reynolds, ES
Published in: Arzneimittelforschung
1977

A single injection of vinblastine given i.v. to rats lead to the disappearance of microtubules, development of crystalline inclusions, dilation of Golgi sacculi, formation of multivesicular bodies and cytosegresomes as well as accumulation of lysosomes in the cytoplasm of liver cells. The endoplasmic reticulum and mitochondria do not seem to be affected. The question of whether or not these fine structural alterations are causally related has yet to be elucidated.

Duke Scholars

Published In

Arzneimittelforschung

ISSN

0004-4172

Publication Date

1977

Volume

27

Issue

4

Start / End Page

825 / 828

Location

Germany

Related Subject Headings

  • Vinblastine
  • Rats
  • Pharmacology & Pharmacy
  • Microtubules
  • Microscopy, Electron
  • Male
  • Lysosomes
  • Liver
  • Inclusion Bodies
  • Golgi Apparatus
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kovacs, K., Horvath, E., Szabo, S., Dzau, V. J., & Reynolds, E. S. (1977). Effect of vinblastine on rat liver ultrastructure. Arzneimittelforschung, 27(4), 825–828.
Kovacs, K., E. Horvath, S. Szabo, V. J. Dzau, and E. S. Reynolds. “Effect of vinblastine on rat liver ultrastructure.Arzneimittelforschung 27, no. 4 (1977): 825–28.
Kovacs K, Horvath E, Szabo S, Dzau VJ, Reynolds ES. Effect of vinblastine on rat liver ultrastructure. Arzneimittelforschung. 1977;27(4):825–8.
Kovacs, K., et al. “Effect of vinblastine on rat liver ultrastructure.Arzneimittelforschung, vol. 27, no. 4, 1977, pp. 825–28.
Kovacs K, Horvath E, Szabo S, Dzau VJ, Reynolds ES. Effect of vinblastine on rat liver ultrastructure. Arzneimittelforschung. 1977;27(4):825–828.
Journal cover image

Published In

Arzneimittelforschung

ISSN

0004-4172

Publication Date

1977

Volume

27

Issue

4

Start / End Page

825 / 828

Location

Germany

Related Subject Headings

  • Vinblastine
  • Rats
  • Pharmacology & Pharmacy
  • Microtubules
  • Microscopy, Electron
  • Male
  • Lysosomes
  • Liver
  • Inclusion Bodies
  • Golgi Apparatus