Effect of vinblastine on rat liver ultrastructure.
Publication
, Journal Article
Kovacs, K; Horvath, E; Szabo, S; Dzau, VJ; Reynolds, ES
Published in: Arzneimittelforschung
1977
A single injection of vinblastine given i.v. to rats lead to the disappearance of microtubules, development of crystalline inclusions, dilation of Golgi sacculi, formation of multivesicular bodies and cytosegresomes as well as accumulation of lysosomes in the cytoplasm of liver cells. The endoplasmic reticulum and mitochondria do not seem to be affected. The question of whether or not these fine structural alterations are causally related has yet to be elucidated.
Duke Scholars
Published In
Arzneimittelforschung
ISSN
0004-4172
Publication Date
1977
Volume
27
Issue
4
Start / End Page
825 / 828
Location
Germany
Related Subject Headings
- Vinblastine
- Rats
- Pharmacology & Pharmacy
- Microtubules
- Microscopy, Electron
- Male
- Lysosomes
- Liver
- Inclusion Bodies
- Golgi Apparatus
Citation
APA
Chicago
ICMJE
MLA
NLM
Kovacs, K., Horvath, E., Szabo, S., Dzau, V. J., & Reynolds, E. S. (1977). Effect of vinblastine on rat liver ultrastructure. Arzneimittelforschung, 27(4), 825–828.
Kovacs, K., E. Horvath, S. Szabo, V. J. Dzau, and E. S. Reynolds. “Effect of vinblastine on rat liver ultrastructure.” Arzneimittelforschung 27, no. 4 (1977): 825–28.
Kovacs K, Horvath E, Szabo S, Dzau VJ, Reynolds ES. Effect of vinblastine on rat liver ultrastructure. Arzneimittelforschung. 1977;27(4):825–8.
Kovacs, K., et al. “Effect of vinblastine on rat liver ultrastructure.” Arzneimittelforschung, vol. 27, no. 4, 1977, pp. 825–28.
Kovacs K, Horvath E, Szabo S, Dzau VJ, Reynolds ES. Effect of vinblastine on rat liver ultrastructure. Arzneimittelforschung. 1977;27(4):825–828.
Published In
Arzneimittelforschung
ISSN
0004-4172
Publication Date
1977
Volume
27
Issue
4
Start / End Page
825 / 828
Location
Germany
Related Subject Headings
- Vinblastine
- Rats
- Pharmacology & Pharmacy
- Microtubules
- Microscopy, Electron
- Male
- Lysosomes
- Liver
- Inclusion Bodies
- Golgi Apparatus