Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.

Journal Article (Journal Article)

Clinical evidence suggests that cellular immunity is involved in controlling human immunodeficiency virus-1 (HIV-1) replication. An animal model of acquired immune deficiency syndrome (AIDS), the simian immunodeficiency virus (SIV)-infected rhesus monkey, was used to show that virus replication is not controlled in monkeys depleted of CD8+ lymphocytes during primary SIV infection. Eliminating CD8+ lymphocytes from monkeys during chronic SIV infection resulted in a rapid and marked increase in viremia that was again suppressed coincident with the reappearance of SIV-specific CD8+ T cells. These results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses.

Full Text

Duke Authors

Cited Authors

  • Schmitz, JE; Kuroda, MJ; Santra, S; Sasseville, VG; Simon, MA; Lifton, MA; Racz, P; Tenner-Racz, K; Dalesandro, M; Scallon, BJ; Ghrayeb, J; Forman, MA; Montefiori, DC; Rieber, EP; Letvin, NL; Reimann, KA

Published Date

  • February 5, 1999

Published In

Volume / Issue

  • 283 / 5403

Start / End Page

  • 857 - 860

PubMed ID

  • 9933172

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.283.5403.857


  • eng

Conference Location

  • United States