Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.
Clinical evidence suggests that cellular immunity is involved in controlling human immunodeficiency virus-1 (HIV-1) replication. An animal model of acquired immune deficiency syndrome (AIDS), the simian immunodeficiency virus (SIV)-infected rhesus monkey, was used to show that virus replication is not controlled in monkeys depleted of CD8+ lymphocytes during primary SIV infection. Eliminating CD8+ lymphocytes from monkeys during chronic SIV infection resulted in a rapid and marked increase in viremia that was again suppressed coincident with the reappearance of SIV-specific CD8+ T cells. These results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses.
Schmitz, JE; Kuroda, MJ; Santra, S; Sasseville, VG; Simon, MA; Lifton, MA; Racz, P; Tenner-Racz, K; Dalesandro, M; Scallon, BJ; Ghrayeb, J; Forman, MA; Montefiori, DC; Rieber, EP; Letvin, NL; Reimann, KA
Volume / Issue
Start / End Page
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)