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Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.

Publication ,  Journal Article
Schmitz, JE; Kuroda, MJ; Santra, S; Sasseville, VG; Simon, MA; Lifton, MA; Racz, P; Tenner-Racz, K; Dalesandro, M; Scallon, BJ; Ghrayeb, J ...
Published in: Science
February 5, 1999

Clinical evidence suggests that cellular immunity is involved in controlling human immunodeficiency virus-1 (HIV-1) replication. An animal model of acquired immune deficiency syndrome (AIDS), the simian immunodeficiency virus (SIV)-infected rhesus monkey, was used to show that virus replication is not controlled in monkeys depleted of CD8+ lymphocytes during primary SIV infection. Eliminating CD8+ lymphocytes from monkeys during chronic SIV infection resulted in a rapid and marked increase in viremia that was again suppressed coincident with the reappearance of SIV-specific CD8+ T cells. These results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

February 5, 1999

Volume

283

Issue

5403

Start / End Page

857 / 860

Location

United States

Related Subject Headings

  • Virus Replication
  • Viremia
  • Viral Load
  • Time Factors
  • T-Lymphocytes, Cytotoxic
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • RNA, Viral
  • Neutralization Tests
 

Citation

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Schmitz, J. E., Kuroda, M. J., Santra, S., Sasseville, V. G., Simon, M. A., Lifton, M. A., … Reimann, K. A. (1999). Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science, 283(5403), 857–860. https://doi.org/10.1126/science.283.5403.857
Schmitz, J. E., M. J. Kuroda, S. Santra, V. G. Sasseville, M. A. Simon, M. A. Lifton, P. Racz, et al. “Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.Science 283, no. 5403 (February 5, 1999): 857–60. https://doi.org/10.1126/science.283.5403.857.
Schmitz JE, Kuroda MJ, Santra S, Sasseville VG, Simon MA, Lifton MA, et al. Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science. 1999 Feb 5;283(5403):857–60.
Schmitz, J. E., et al. “Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.Science, vol. 283, no. 5403, Feb. 1999, pp. 857–60. Pubmed, doi:10.1126/science.283.5403.857.
Schmitz JE, Kuroda MJ, Santra S, Sasseville VG, Simon MA, Lifton MA, Racz P, Tenner-Racz K, Dalesandro M, Scallon BJ, Ghrayeb J, Forman MA, Montefiori DC, Rieber EP, Letvin NL, Reimann KA. Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science. 1999 Feb 5;283(5403):857–860.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

February 5, 1999

Volume

283

Issue

5403

Start / End Page

857 / 860

Location

United States

Related Subject Headings

  • Virus Replication
  • Viremia
  • Viral Load
  • Time Factors
  • T-Lymphocytes, Cytotoxic
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • RNA, Viral
  • Neutralization Tests