Instrumentation for multi-modal spectroscopic diagnosis of epithelial dysplasia.
Journal Article (Journal Article)
Reflectance and fluorescence spectroscopies have shown great promise for early detection of epithelial dysplasia. We have developed a clinical reflectance spectrofluorimeter for multimodal spectroscopic diagnosis of epithelial dysplasia. This clinical instrument, the FastEEM, collects white light reflectance and fluorescence excitation-emission matrices (EEM's) within a fraction of a second. In this paper we describe the FastEEM instrumentation, designed for collection of multi-modal spectroscopic data. We illustrate its performance using tissue phantoms with well defined optical properties and biochemicals of known fluorescence properties. In addition, we discuss our plans to develop a system that combines a multi-spectral imaging device for wide area surveillance with this contact probe device.
- Tunnell, JW; Desjardins, AE; Galindo, L; Georgakoudi, I; McGee, SA; Mirkovic, J; Mueller, MG; Nazemi, J; Nguyen, FT; Wax, A; Zhang, Q; Dasari, RR; Feld, MS
- December 2003
Volume / Issue
- 2 / 6
Start / End Page
- 505 - 514
Electronic International Standard Serial Number (EISSN)
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)