Instrumentation for multi-modal spectroscopic diagnosis of epithelial dysplasia.

Journal Article (Journal Article)

Reflectance and fluorescence spectroscopies have shown great promise for early detection of epithelial dysplasia. We have developed a clinical reflectance spectrofluorimeter for multimodal spectroscopic diagnosis of epithelial dysplasia. This clinical instrument, the FastEEM, collects white light reflectance and fluorescence excitation-emission matrices (EEM's) within a fraction of a second. In this paper we describe the FastEEM instrumentation, designed for collection of multi-modal spectroscopic data. We illustrate its performance using tissue phantoms with well defined optical properties and biochemicals of known fluorescence properties. In addition, we discuss our plans to develop a system that combines a multi-spectral imaging device for wide area surveillance with this contact probe device.

Full Text

Duke Authors

Cited Authors

  • Tunnell, JW; Desjardins, AE; Galindo, L; Georgakoudi, I; McGee, SA; Mirkovic, J; Mueller, MG; Nazemi, J; Nguyen, FT; Wax, A; Zhang, Q; Dasari, RR; Feld, MS

Published Date

  • December 2003

Published In

Volume / Issue

  • 2 / 6

Start / End Page

  • 505 - 514

PubMed ID

  • 14640762

Electronic International Standard Serial Number (EISSN)

  • 1533-0338

International Standard Serial Number (ISSN)

  • 1533-0346

Digital Object Identifier (DOI)

  • 10.1177/153303460300200603


  • eng