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Instrumentation for multi-modal spectroscopic diagnosis of epithelial dysplasia.

Publication ,  Journal Article
Tunnell, JW; Desjardins, AE; Galindo, L; Georgakoudi, I; McGee, SA; Mirkovic, J; Mueller, MG; Nazemi, J; Nguyen, FT; Wax, A; Zhang, Q ...
Published in: Technology in cancer research & treatment
December 2003
Published version (DOI)

Reflectance and fluorescence spectroscopies have shown great promise for early detection of epithelial dysplasia. We have developed a clinical reflectance spectrofluorimeter for multimodal spectroscopic diagnosis of epithelial dysplasia. This clinical instrument, the FastEEM, collects white light reflectance and fluorescence excitation-emission matrices (EEM's) within a fraction of a second. In this paper we describe the FastEEM instrumentation, designed for collection of multi-modal spectroscopic data. We illustrate its performance using tissue phantoms with well defined optical properties and biochemicals of known fluorescence properties. In addition, we discuss our plans to develop a system that combines a multi-spectral imaging device for wide area surveillance with this contact probe device.

Duke Scholars

Adam P. Wax
Author Adam P. Wax Biomedical Engineering
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Published In

Technology in cancer research & treatment

DOI

10.1177/153303460300200603

EISSN

1533-0338

ISSN

1533-0346

Publication Date

December 2003

Volume

2

Issue

6

Start / End Page

505 / 514

Related Subject Headings

  • Spectrum Analysis
  • Spectrometry, Fluorescence
  • Software
  • Phantoms, Imaging
  • Optics and Photonics
  • Oncology & Carcinogenesis
  • Humans
  • Fiber Optic Technology
  • Epithelium
  • Carcinoma
 

Citation

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MLA
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Tunnell, J. W., Desjardins, A. E., Galindo, L., Georgakoudi, I., McGee, S. A., Mirkovic, J., … Feld, M. S. (2003). Instrumentation for multi-modal spectroscopic diagnosis of epithelial dysplasia. Technology in Cancer Research & Treatment, 2(6), 505–514. https://doi.org/10.1177/153303460300200603
Tunnell, J. W., A. E. Desjardins, L. Galindo, I. Georgakoudi, S. A. McGee, J. Mirkovic, M. G. Mueller, et al. “Instrumentation for multi-modal spectroscopic diagnosis of epithelial dysplasia.” Technology in Cancer Research & Treatment 2, no. 6 (December 2003): 505–14. https://doi.org/10.1177/153303460300200603.
Tunnell JW, Desjardins AE, Galindo L, Georgakoudi I, McGee SA, Mirkovic J, et al. Instrumentation for multi-modal spectroscopic diagnosis of epithelial dysplasia. Technology in cancer research & treatment. 2003 Dec;2(6):505–14.
Tunnell, J. W., et al. “Instrumentation for multi-modal spectroscopic diagnosis of epithelial dysplasia.” Technology in Cancer Research & Treatment, vol. 2, no. 6, Dec. 2003, pp. 505–14. Epmc, doi:10.1177/153303460300200603.
Tunnell JW, Desjardins AE, Galindo L, Georgakoudi I, McGee SA, Mirkovic J, Mueller MG, Nazemi J, Nguyen FT, Wax A, Zhang Q, Dasari RR, Feld MS. Instrumentation for multi-modal spectroscopic diagnosis of epithelial dysplasia. Technology in cancer research & treatment. 2003 Dec;2(6):505–514.
Journal cover image

Published In

Technology in cancer research & treatment

DOI

10.1177/153303460300200603

EISSN

1533-0338

ISSN

1533-0346

Publication Date

December 2003

Volume

2

Issue

6

Start / End Page

505 / 514

Related Subject Headings

  • Spectrum Analysis
  • Spectrometry, Fluorescence
  • Software
  • Phantoms, Imaging
  • Optics and Photonics
  • Oncology & Carcinogenesis
  • Humans
  • Fiber Optic Technology
  • Epithelium
  • Carcinoma