Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.

Published

Journal Article

From the age of 3 months until their natural deaths, female outbred Swiss-derived SHR mice were subcutaneously injected on 5 consecutive days every month with 0.1 ml of normal saline (control) or with 1.0 microg/mouse (approximately 30-40 microg/kg) of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) dissolved in 0.1 ml saline. There were 54 mice in each group. The results of this study show that treatment with Epitalon did not influence food consumption, body weight or mean life span of mice. However, it slowed down the age-related switching-off of estrous function and decreased the frequency of chromosome aberrations in bone marrow cells (by 17.1%, P<0.05). It also increased by 13.3% the life span of the last 10% of the survivors (P<0.01) and by 12.3% the maximum life span in comparison with the control group. We also found that treatment with Epitalon did not influence total spontaneous tumor incidence, but inhibited the development of leukemia (6.0-fold), as compared with the control group. The data obtained suggest a geroprotector activity of Epitalon and the safety of its long-term administration in mice.

Full Text

Duke Authors

Cited Authors

  • Anisimov, VN; Khavinson, VK; Popovich, IG; Zabezhinski, MA; Alimova, IN; Rosenfeld, SV; Zavarzina, NY; Semenchenko, AV; Yashin, AI

Published Date

  • January 2003

Published In

Volume / Issue

  • 4 / 4

Start / End Page

  • 193 - 202

PubMed ID

  • 14501183

Pubmed Central ID

  • 14501183

Electronic International Standard Serial Number (EISSN)

  • 1573-6768

International Standard Serial Number (ISSN)

  • 1389-5729

Digital Object Identifier (DOI)

  • 10.1023/a:1025114230714

Language

  • eng