Design and synthesis of manganese porphyrins with tailored lipophilicity: investigation of redox properties and superoxide dismutase activity.

Published

Journal Article

Thirteen new manganese porphyrins and two porphodimethenes bearing one to three different substituents at the meso positions in a variety of architectures have been synthesized. The substituents employed generally are (i) electron-withdrawing to tune the reduction potential to the desirable range (near +0.3V vs NHE), and/or (ii) lipophilic to target the interior of lipid bilayer membranes and/or the blood-brain barrier. The influence of the substituents on the Mn(III)/Mn(II) reduction potentials has been characterized, and the superoxide dismutase activity of the compounds has been examined.

Full Text

Duke Authors

Cited Authors

  • Lahaye, D; Muthukumaran, K; Hung, C-H; Gryko, D; Rebouças, JS; Spasojević, I; Batinić-Haberle, I; Lindsey, JS

Published Date

  • November 2007

Published In

Volume / Issue

  • 15 / 22

Start / End Page

  • 7066 - 7086

PubMed ID

  • 17822908

Pubmed Central ID

  • 17822908

Electronic International Standard Serial Number (EISSN)

  • 1464-3391

International Standard Serial Number (ISSN)

  • 0968-0896

Digital Object Identifier (DOI)

  • 10.1016/j.bmc.2007.07.015

Language

  • eng