Design and synthesis of manganese porphyrins with tailored lipophilicity: investigation of redox properties and superoxide dismutase activity.
Journal Article (Journal Article)
Thirteen new manganese porphyrins and two porphodimethenes bearing one to three different substituents at the meso positions in a variety of architectures have been synthesized. The substituents employed generally are (i) electron-withdrawing to tune the reduction potential to the desirable range (near +0.3V vs NHE), and/or (ii) lipophilic to target the interior of lipid bilayer membranes and/or the blood-brain barrier. The influence of the substituents on the Mn(III)/Mn(II) reduction potentials has been characterized, and the superoxide dismutase activity of the compounds has been examined.
Full Text
Duke Authors
Cited Authors
- Lahaye, D; Muthukumaran, K; Hung, C-H; Gryko, D; Rebouças, JS; Spasojević, I; Batinić-Haberle, I; Lindsey, JS
Published Date
- November 15, 2007
Published In
Volume / Issue
- 15 / 22
Start / End Page
- 7066 - 7086
PubMed ID
- 17822908
Pubmed Central ID
- PMC2111292
International Standard Serial Number (ISSN)
- 0968-0896
Digital Object Identifier (DOI)
- 10.1016/j.bmc.2007.07.015
Language
- eng
Conference Location
- England