Noninvasive cineangiography by magnetic resonance global coherent free precession.

Journal Article (Journal Article)

Cardiovascular disease is primarily diagnosed using invasive X-ray cineangiography. Here we introduce a new concept in magnetic resonance imaging (MRI) that, for the first time, produces similar images noninvasively and without a contrast agent. Protons in moving blood are 'tagged' every few milliseconds as they travel through an arbitrary region in space. Simultaneous with ongoing tagging of new blood, previously tagged blood is maintained in a state of global coherent free precession (GCFP), which allows acquisition of consecutive movie frames as the heart pushes blood through the vascular bed. Body tissue surrounding the moving blood is never excited and therefore remains invisible. In 18 subjects, pulsating blood could be seen flowing through three-dimensional (3D) space for distances of up to 16 cm outside the stationary excitation region. These data underscore that our approach noninvasively characterizes both anatomy and blood flow in a manner directly analogous to invasive procedures.

Full Text

Duke Authors

Cited Authors

  • Rehwald, WG; Chen, E-L; Kim, RJ; Judd, RM

Published Date

  • May 2004

Published In

Volume / Issue

  • 10 / 5

Start / End Page

  • 545 - 549

PubMed ID

  • 15064758

International Standard Serial Number (ISSN)

  • 1078-8956

Digital Object Identifier (DOI)

  • 10.1038/nm1027


  • eng

Conference Location

  • United States