Enn-Ling Chen
Assistant Professor in Medicine
Current Appointments & Affiliations
- Assistant Professor in Medicine, Medicine, Cardiology, Medicine 2021
Contact Information
- Duke Box 3934, Durham, NC 27710
- Duke Medicine Pavilion, 10 Duke Medicine Circle, Rm 1E-59, Durham, NC 27710
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chen0060@duke.edu
(919) 668-3539
- Background
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Education, Training, & Certifications
- Ph.D., University of Pennsylvania 1998
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Previous Appointments & Affiliations
- Assistant Professor in Medicine, Medicine, Cardiology, Medicine 2006 - 2020
- Assistant Research Professor in Medicine, Medicine, Cardiology, Medicine 2002 - 2006
- Instructor, Temporary in the Department of Medicine, Medicine, Cardiology, Medicine 2001 - 2002
- Research
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Selected Grants
- Medical Images, HTML5, and Clinical Trial Remote Collaboration awarded by Heart Imaging Technologies, LLC 2017 - 2019
- Delayed-Enhancement Cardiac MRI: Prognostic Implications and Improved Imaging awarded by National Institutes of Health 2010 - 2015
- Defining Myocardial Viability & Infarction:Contrast MRI awarded by National Institutes of Health 1999 - 2009
- Dynamic Magnetic Resonance Selective Angiography awarded by National Institutes of Health 2004 - 2009
- Contrast MRI and Chronic Myocardial Injury in Humans awarded by National Institutes of Health 2001 - 2007
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Kaolawanich, Yodying, Clerio F. Azevedo, Han W. Kim, Elizabeth R. Jenista, David C. Wendell, Enn-Ling Chen, Michele A. Parker, Robert M. Judd, and Raymond J. Kim. “Native T1 Mapping for the Diagnosis of Myocardial Fibrosis in Patients With Chronic Myocardial Infarction.” Jacc Cardiovasc Imaging 15, no. 12 (December 2022): 2069–79. https://doi.org/10.1016/j.jcmg.2022.09.011.Full Text Link to Item
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Wendell, David, Elizabeth Jenista, Han W. Kim, Enn-Ling Chen, Clerio F. Azevedo, Yodying Kaolawanich, Fawaz Alenezi, et al. “Assessment of Papillary Muscle Infarction with Dark-Blood Delayed Enhancement Cardiac MRI in Canines and Humans.” Radiology 305, no. 2 (November 2022): 329–38. https://doi.org/10.1148/radiol.220251.Full Text Link to Item
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Azevedo, Clerio F., Elizabeth R. Jenista, Yodying Kaolawanich, Han W. Kim, David C. Wendell, Fawaz Alenezi, Enn-Ling Chen, Michele A. Parker, Robert M. Judd, and Raymond J. Kim. “Assessment of myocardial lipomatous metaplasia using an optimized out-of-phase cine steady-state free-precession sequence: Validation and clinical implementation.” Nmr Biomed 35, no. 10 (October 2022): e4777. https://doi.org/10.1002/nbm.4777.Full Text Link to Item
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Jenista, Elizabeth R., Christoph J. Jensen, David Wendell, Deneen Spatz, Stephen Darty, Han W. Kim, Michele Parker, et al. “Double spectral attenuated inversion recovery (DSPAIR)-an efficient fat suppression technique for late gadolinium enhancement at 3 tesla.” Nmr Biomed 34, no. 10 (October 2021): e4580. https://doi.org/10.1002/nbm.4580.Full Text Link to Item
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Jenista, Elizabeth R., David C. Wendell, Han W. Kim, Wolfgang G. Rehwald, Enn-Ling Chen, Stephen N. Darty, Logan R. Smith, Clerio F. Azevedo, Michele A. Parker, and Raymond J. Kim. “Comparison of magnetization transfer-preparation and T2-preparation for dark-blood delayed-enhancement imaging.” Nmr Biomed 33, no. 11 (November 2020): e4396. https://doi.org/10.1002/nbm.4396.Full Text Link to Item
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Kim, Han W., Wolfgang G. Rehwald, Elizabeth R. Jenista, David C. Wendell, Peter Filev, Lowie van Assche, Christoph J. Jensen, et al. “Dark-Blood Delayed Enhancement Cardiac Magnetic Resonance of Myocardial Infarction.” Jacc Cardiovasc Imaging 11, no. 12 (December 2018): 1758–69. https://doi.org/10.1016/j.jcmg.2017.09.021.Full Text Open Access Copy Link to Item
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Jenista, Elizabeth R., Wolfgang G. Rehwald, Nayla H. Chaptini, Han W. Kim, Michele A. Parker, David C. Wendell, Enn-Ling Chen, and Raymond J. Kim. “Suppression of ghost artifacts arising from long T1 species in segmented inversion-recovery imaging.” Magn Reson Med 78, no. 4 (October 2017): 1442–51. https://doi.org/10.1002/mrm.26554.Full Text Link to Item
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Kim, H. W., W. G. Rehwald, D. C. Wendell, E. Jenista, L. Van Assche, C. J. Jensen, E. L. Chen, M. Parker, and R. Kim. “Flow-independent dark-blood delayed enhancement (Fiddle): Validation of a novel black blood technique for the diagnosis of myocardial infarction.” Journal of Cardiovascular Magnetic Resonance 18 (January 1, 2016): 1–3. https://doi.org/10.1186/1532-429X-18-S1-O55.Full Text
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Wendell, D., E. Jenista, W. G. Rehwald, H. W. Kim, M. Parker, E. L. Chen, R. Judd, and R. Kim. “Validation of a novel dark-blood delayed enhancement technique for the detection of papillary muscle SCAR.” Journal of Cardiovascular Magnetic Resonance 18 (January 1, 2016): 1–2. https://doi.org/10.1186/1532-429X-18-S1-Q6.Full Text
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Wendell, D., H. W. Kim, E. Jenista, W. G. Rehwald, M. Parker, E. L. Chen, P. Chattranukulchai, R. Judd, and R. Kim. “Relationship between the transmural extent of high resolution parametric (T1-and t2) mapping and the ischemic area at risk defined by pathology.” Journal of Cardiovascular Magnetic Resonance 18 (January 1, 2016): 1–3. https://doi.org/10.1186/1532-429X-18-S1-O44.Full Text
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Kim, Han W., Lowie Van Assche, Robert B. Jennings, W Benjamin Wince, Christoph J. Jensen, Wolfgang G. Rehwald, David C. Wendell, et al. “Relationship of T2-Weighted MRI Myocardial Hyperintensity and the Ischemic Area-At-Risk.” Circ Res 117, no. 3 (July 17, 2015): 254–65. https://doi.org/10.1161/CIRCRESAHA.117.305771.Full Text Open Access Copy Link to Item
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Jenista, Elizabeth R., Wolfgang G. Rehwald, Enn-Ling Chen, Han W. Kim, Igor Klem, Michele A. Parker, and Raymond J. Kim. “Motion and flow insensitive adiabatic T2 -preparation module for cardiac MR imaging at 3 Tesla.” Magn Reson Med 70, no. 5 (November 2013): 1360–68. https://doi.org/10.1002/mrm.24564.Full Text Link to Item
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Chen, Enn-Ling, and Raymond J. Kim. “Magnetic resonance water proton relaxation in protein solutions and tissue: T(1rho) dispersion characterization.” Plos One 5, no. 1 (January 5, 2010): e8565. https://doi.org/10.1371/journal.pone.0008565.Full Text Open Access Copy Link to Item
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Rehwald, Wolfgang G., Michael Salerno, Enn-Ling Chen, Burkhard Sievers, Raymond J. Kim, and Robert M. Judd. “Combining spin echoes with gradient echoes in the context of the global coherent free precession pulse sequence.” Magn Reson Med 58, no. 1 (July 2007): 82–91. https://doi.org/10.1002/mrm.21269.Full Text Link to Item
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Hillenbrand, Hanns B., Lewis C. Becker, Reza Kharrazian, Kai Hu, Carlos E. Rochitte, Raymond J. Kim, Enn L. Chen, Georg Ertl, Ralph H. Hruban, and João A. C. Lima. “23Na MRI combined with contrast-enhanced 1H MRI provides in vivo characterization of infarct healing.” Magn Reson Med 53, no. 4 (April 2005): 843–50. https://doi.org/10.1002/mrm.20417.Full Text Link to Item
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Klem, Igor, Wolfgang G. Rehwald, John F. Heitner, Anja Wagner, Timothy Albert, Michele A. Parker, Enn-Ling Chen, Raymond J. Kim, and Robert M. Judd. “Noninvasive assessment of blood flow based on magnetic resonance global coherent free precession.” Circulation 111, no. 8 (March 1, 2005): 1033–39. https://doi.org/10.1161/01.CIR.0000156332.56894.22.Full Text Link to Item
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Rehwald, Wolfgang G., Enn-Ling Chen, Raymond J. Kim, and Robert M. Judd. “Noninvasive cineangiography by magnetic resonance global coherent free precession.” Nat Med 10, no. 5 (May 2004): 545–49. https://doi.org/10.1038/nm1027.Full Text Link to Item
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Rehwald, Wolfgang G., David S. Fieno, Enn-Ling Chen, Raymond J. Kim, and Robert M. Judd. “Myocardial magnetic resonance imaging contrast agent concentrations after reversible and irreversible ischemic injury.” Circulation 105, no. 2 (January 15, 2002): 224–29. https://doi.org/10.1161/hc0202.102016.Full Text Link to Item
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Kim, R. J., E. Wu, A. Rafael, E. L. Chen, M. A. Parker, O. Simonetti, F. J. Klocke, R. O. Bonow, and R. M. Judd. “The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction.” N Engl J Med 343, no. 20 (November 16, 2000): 1445–53. https://doi.org/10.1056/NEJM200011163432003.Full Text Link to Item
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Fieno, D. S., R. J. Kim, E. L. Chen, J. W. Lomasney, F. J. Klocke, and R. M. Judd. “Contrast-enhanced magnetic resonance imaging of myocardium at risk: distinction between reversible and irreversible injury throughout infarct healing.” J Am Coll Cardiol 36, no. 6 (November 15, 2000): 1985–91. https://doi.org/10.1016/s0735-1097(00)00958-x.Full Text Link to Item
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Rochitte, C. E., R. J. Kim, H. B. Hillenbrand, E. L. Chen, and J. A. Lima. “Microvascular integrity and the time course of myocardial sodium accumulation after acute infarction.” Circ Res 87, no. 8 (October 13, 2000): 648–55. https://doi.org/10.1161/01.res.87.8.648.Full Text Link to Item
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Kim, R. J., D. S. Fieno, T. B. Parrish, K. Harris, E. L. Chen, O. Simonetti, J. Bundy, J. P. Finn, F. J. Klocke, and R. M. Judd. “Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function.” Circulation 100, no. 19 (November 9, 1999): 1992–2002. https://doi.org/10.1161/01.cir.100.19.1992.Full Text Link to Item
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Kim, R. J., R. M. Judd, E. L. Chen, D. S. Fieno, T. B. Parrish, and J. A. Lima. “Relationship of elevated 23Na magnetic resonance image intensity to infarct size after acute reperfused myocardial infarction.” Circulation 100, no. 2 (July 13, 1999): 185–92. https://doi.org/10.1161/01.cir.100.2.185.Full Text Link to Item
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Noyszewski, E. A., E. L. Chen, R. Reddy, Z. Wang, and J. S. Leigh. “A simplified sequence for observing deoxymyoglobin signals in vivo: myoglobin excitation with dynamic unexcitation and saturation of water and fat (MEDUSA).” Magn Reson Med 38, no. 5 (November 1997): 788–92. https://doi.org/10.1002/mrm.1910380515.Full Text Link to Item
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Kim, R. J., J. A. Lima, E. L. Chen, S. B. Reeder, F. J. Klocke, E. A. Zerhouni, and R. M. Judd. “Fast 23Na magnetic resonance imaging of acute reperfused myocardial infarction. Potential to assess myocardial viability.” Circulation 95, no. 7 (April 1, 1997): 1877–85. https://doi.org/10.1161/01.cir.95.7.1877.Full Text Link to Item
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Kim, R. J., J. A. C. Lima, E. L. Chen, S. B. Reeder, F. J. Klocke, E. A. Zerhouni, and R. M. Judd. “Fast 23Na magnetic resonance imaging of acute reperfused myocardial infarction: Potential to assess myocardial viability.” Circulation 95, no. 7 (1997): 1877–85.
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Kim, R. J., E. L. Chen, J. A. Lima, and R. M. Judd. “Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury after acute reperfused infarction.” Circulation 94, no. 12 (December 15, 1996): 3318–26. https://doi.org/10.1161/01.cir.94.12.3318.Full Text Link to Item
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Conference Papers
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Jenista, E., D. Wendell, D. Spatz, C. Jensen, L. Van Assche, E. Chen, R. Kim, and W. Rehwald. “Phase Sensitive Fat Darkening by TI-Minimized Double SPAIR (PHATTI DeSPAIR) for Robust and Highly Effective Fat Suppression in Clinical T1-Weighted Imaging of Ischemic and Non-Ischemic Heart Disease,” n.d.
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Jenista, E., D. Wendell, H. Kim, S. Darty, A. Crowley, E. Chen, W. Rehwald, M. Parker, and R. Kim. “Virtual Chemical Inversion - A Novel Fat Suppression Technique for T1-Weighted Cardiac Imaging with Improved Delineation of the Fat-Myocardium Interface.” In Journal of Cardiovascular Magnetic Resonance, Vol. 15 Supplement 1. BioMed Central, n.d.
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Jenista, E., D. Wendell, H. Kim, W. Rehwald, S. Darty, E. Chen, M. Parker, and R. Kim. “Comparison of T2-preparation and Magnetization-Transfer Preparation for Black Blood Delayed Enhancement.” In Journal of Cardiovascular Magnetic Resonance, Vol. 18 Supplement 1. BioMed Central, n.d.
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Jenista, E., D. wendell, H. kim, D. Labib, S. Chang, W. Rehwald, E. Chen, M. Parker, and R. Kim. “Accuracy of ECV imaging for the detection of subendocardial infarction – comparison with black blood delayed enhancement and pathology.” In Journal of Cardiovascular Magnetic Resonance, Vol. 18 Supplement 1. BioMed Central, n.d.
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Jenista, E., W. Rehwald, H. Kim, S. Darty, D. Spatz, E. Chen, and R. Kim. “Phase sensitive inversion recovery with simultaneous dark fat rendering by virtual chemical inversion.” In Journal of Cardiovascular Magnetic Resonance, Vol. 14 Supplement 1. BioMed Central, n.d.
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Jenista, E., W. Rehwald, I. Klem, M. Parker, E. Chen, and R. Kim. “Design of an adiabatic T2-preparation method optimized for cardiac motion and flow insensitivity at 3T.” In Journal of Cardiovascular Magnetic Resonance, Vol. 13 Supplement 1. BioMed Central, n.d.
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