The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome.

Journal Article (Journal Article)

We have sequenced and annotated the genome of the filamentous ascomycete Ashbya gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the smallest genome of a free-living eukaryote yet characterized. More than 90% of A. gossypii genes show both homology and a particular pattern of synteny with Saccharomyces cerevisiae. Analysis of this pattern revealed 300 inversions and translocations that have occurred since divergence of these two species. It also provided compelling evidence that the evolution of S. cerevisiae included a whole genome duplication or fusion of two related species and showed, through inferred ancient gene orders, which of the duplicated genes lost one copy and which retained both copies.

Full Text

Duke Authors

Cited Authors

  • Dietrich, FS; Voegeli, S; Brachat, S; Lerch, A; Gates, K; Steiner, S; Mohr, C; Pöhlmann, R; Luedi, P; Choi, S; Wing, RA; Flavier, A; Gaffney, TD; Philippsen, P

Published Date

  • April 9, 2004

Published In

Volume / Issue

  • 304 / 5668

Start / End Page

  • 304 - 307

PubMed ID

  • 15001715

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.1095781


  • eng

Conference Location

  • United States