The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome.
Publication
, Journal Article
Dietrich, FS; Voegeli, S; Brachat, S; Lerch, A; Gates, K; Steiner, S; Mohr, C; Pöhlmann, R; Luedi, P; Choi, S; Wing, RA; Flavier, A ...
Published in: Science
April 9, 2004
We have sequenced and annotated the genome of the filamentous ascomycete Ashbya gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the smallest genome of a free-living eukaryote yet characterized. More than 90% of A. gossypii genes show both homology and a particular pattern of synteny with Saccharomyces cerevisiae. Analysis of this pattern revealed 300 inversions and translocations that have occurred since divergence of these two species. It also provided compelling evidence that the evolution of S. cerevisiae included a whole genome duplication or fusion of two related species and showed, through inferred ancient gene orders, which of the duplicated genes lost one copy and which retained both copies.
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Published In
Science
DOI
EISSN
1095-9203
Publication Date
April 9, 2004
Volume
304
Issue
5668
Start / End Page
304 / 307
Location
United States
Related Subject Headings
- Translocation, Genetic
- Synteny
- Sequence Homology, Nucleic Acid
- Sequence Analysis, DNA
- Sequence Alignment
- Saccharomycetales
- Saccharomyces cerevisiae
- Open Reading Frames
- Molecular Sequence Data
- Genome, Fungal
Citation
APA
Chicago
ICMJE
MLA
NLM
Dietrich, F. S., Voegeli, S., Brachat, S., Lerch, A., Gates, K., Steiner, S., … Philippsen, P. (2004). The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome. Science, 304(5668), 304–307. https://doi.org/10.1126/science.1095781
Dietrich, Fred S., Sylvia Voegeli, Sophie Brachat, Anita Lerch, Krista Gates, Sabine Steiner, Christine Mohr, et al. “The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome.” Science 304, no. 5668 (April 9, 2004): 304–7. https://doi.org/10.1126/science.1095781.
Dietrich FS, Voegeli S, Brachat S, Lerch A, Gates K, Steiner S, et al. The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome. Science. 2004 Apr 9;304(5668):304–7.
Dietrich, Fred S., et al. “The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome.” Science, vol. 304, no. 5668, Apr. 2004, pp. 304–07. Pubmed, doi:10.1126/science.1095781.
Dietrich FS, Voegeli S, Brachat S, Lerch A, Gates K, Steiner S, Mohr C, Pöhlmann R, Luedi P, Choi S, Wing RA, Flavier A, Gaffney TD, Philippsen P. The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome. Science. 2004 Apr 9;304(5668):304–307.
Published In
Science
DOI
EISSN
1095-9203
Publication Date
April 9, 2004
Volume
304
Issue
5668
Start / End Page
304 / 307
Location
United States
Related Subject Headings
- Translocation, Genetic
- Synteny
- Sequence Homology, Nucleic Acid
- Sequence Analysis, DNA
- Sequence Alignment
- Saccharomycetales
- Saccharomyces cerevisiae
- Open Reading Frames
- Molecular Sequence Data
- Genome, Fungal