Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo.

Journal Article (Journal Article)

In mammals, 16 members of the Fgf family have so far been described with diverse roles in embryonic cell growth and differentiation. Here, we report the expression from early streak stage to midgestation of two newly-identified murine genes, Fgf17 and Fgf18, that are most closely related to Fgf8 (63.7% and 56.8% identical, respectively, at the amino acid level). Fgf17 is expressed during gastrulation but at lower levels than Fgf8, while Fgf18 RNA is not expressed until later, in paraxial mesoderm. In the developing tail bud, each Fgf gene shows a different pattern of transcription. Distinct and overlapping expression patterns are also described in the developing brain and limbs.

Full Text

Duke Authors

Cited Authors

  • Maruoka, Y; Ohbayashi, N; Hoshikawa, M; Itoh, N; Hogan, BL; Furuta, Y

Published Date

  • June 1998

Published In

Volume / Issue

  • 74 / 1-2

Start / End Page

  • 175 - 177

PubMed ID

  • 9651520

International Standard Serial Number (ISSN)

  • 0925-4773

Digital Object Identifier (DOI)

  • 10.1016/s0925-4773(98)00061-6


  • eng

Conference Location

  • Ireland