Cell lines derived from pancreatic islets.

Journal Article (Review)

The islets of Langerhans play a major role in control of metabolic fuel homeostasis. The rapid increase in incidence of diabetes worldwide has spurred renewed interest in islet cell biology. However, gaining a detailed understanding of islet function at a molecular and biochemical level has been complicated by the difficulty and high cost associated with isolation of pancreatic islets. Until recently, islet-derived cell lines have represented sub-optimal surrogates for primary cells for functional studies due to their undifferentiated or unstable phenotypic features. New approaches have resulted in isolation and characterization of rodent insulinoma cell lines that retain many key functional attributes of normal islets and have become useful tools in the study of islet cell biology.

Full Text

Duke Authors

Cited Authors

  • Hohmeier, HE; Newgard, CB

Published Date

  • December 30, 2004

Published In

Volume / Issue

  • 228 / 1-2

Start / End Page

  • 121 - 128

PubMed ID

  • 15541576

International Standard Serial Number (ISSN)

  • 0303-7207

Digital Object Identifier (DOI)

  • 10.1016/j.mce.2004.04.017

Language

  • eng

Conference Location

  • Ireland