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Cell lines derived from pancreatic islets.

Publication ,  Journal Article
Hohmeier, HE; Newgard, CB
Published in: Mol Cell Endocrinol
December 30, 2004

The islets of Langerhans play a major role in control of metabolic fuel homeostasis. The rapid increase in incidence of diabetes worldwide has spurred renewed interest in islet cell biology. However, gaining a detailed understanding of islet function at a molecular and biochemical level has been complicated by the difficulty and high cost associated with isolation of pancreatic islets. Until recently, islet-derived cell lines have represented sub-optimal surrogates for primary cells for functional studies due to their undifferentiated or unstable phenotypic features. New approaches have resulted in isolation and characterization of rodent insulinoma cell lines that retain many key functional attributes of normal islets and have become useful tools in the study of islet cell biology.

Duke Scholars

Published In

Mol Cell Endocrinol

DOI

ISSN

0303-7207

Publication Date

December 30, 2004

Volume

228

Issue

1-2

Start / End Page

121 / 128

Location

Ireland

Related Subject Headings

  • Stem Cells
  • Islets of Langerhans
  • Endocrinology & Metabolism
  • Cell Line
  • Animals
  • 3202 Clinical sciences
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 11 Medical and Health Sciences
  • 07 Agricultural and Veterinary Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hohmeier, H. E., & Newgard, C. B. (2004). Cell lines derived from pancreatic islets. Mol Cell Endocrinol, 228(1–2), 121–128. https://doi.org/10.1016/j.mce.2004.04.017
Hohmeier, Hans E., and Christopher B. Newgard. “Cell lines derived from pancreatic islets.Mol Cell Endocrinol 228, no. 1–2 (December 30, 2004): 121–28. https://doi.org/10.1016/j.mce.2004.04.017.
Hohmeier HE, Newgard CB. Cell lines derived from pancreatic islets. Mol Cell Endocrinol. 2004 Dec 30;228(1–2):121–8.
Hohmeier, Hans E., and Christopher B. Newgard. “Cell lines derived from pancreatic islets.Mol Cell Endocrinol, vol. 228, no. 1–2, Dec. 2004, pp. 121–28. Pubmed, doi:10.1016/j.mce.2004.04.017.
Hohmeier HE, Newgard CB. Cell lines derived from pancreatic islets. Mol Cell Endocrinol. 2004 Dec 30;228(1–2):121–128.
Journal cover image

Published In

Mol Cell Endocrinol

DOI

ISSN

0303-7207

Publication Date

December 30, 2004

Volume

228

Issue

1-2

Start / End Page

121 / 128

Location

Ireland

Related Subject Headings

  • Stem Cells
  • Islets of Langerhans
  • Endocrinology & Metabolism
  • Cell Line
  • Animals
  • 3202 Clinical sciences
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 11 Medical and Health Sciences
  • 07 Agricultural and Veterinary Sciences