Disc formation in cholesterol-free liposomes during phase transition.

Journal Article (Journal Article)

Cryogenic transmission electron microscopy (cryo-TEM) images of lysolipid-containing thermosensitive liposomes (LTSL) revealed that open liposomes and bilayer discs appeared when liposomes were cycled through the gel (Lbeta') to liquid-crystalline (Lalpha) phase transition. The amount of bilayer discs generated was dependent on the combined presence of PEG-lipid and lysolipid in the membrane. We hypothesize that micelle-forming membrane components stabilize the rim of bilayer openings and membrane discs that form when liposomes are cycled through TC.

Full Text

Duke Authors

Cited Authors

  • Ickenstein, LM; Arfvidsson, MC; Needham, D; Mayer, LD; Edwards, K

Published Date

  • August 2003

Published In

Volume / Issue

  • 1614 / 2

Start / End Page

  • 135 - 138

PubMed ID

  • 12896806

Electronic International Standard Serial Number (EISSN)

  • 1878-2434

International Standard Serial Number (ISSN)

  • 0006-3002

Digital Object Identifier (DOI)

  • 10.1016/s0005-2736(03)00196-2


  • eng