Disc formation in cholesterol-free liposomes during phase transition.
Publication
, Journal Article
Ickenstein, LM; Arfvidsson, MC; Needham, D; Mayer, LD; Edwards, K
Published in: Biochimica et biophysica acta
August 2003
Cryogenic transmission electron microscopy (cryo-TEM) images of lysolipid-containing thermosensitive liposomes (LTSL) revealed that open liposomes and bilayer discs appeared when liposomes were cycled through the gel (Lbeta') to liquid-crystalline (Lalpha) phase transition. The amount of bilayer discs generated was dependent on the combined presence of PEG-lipid and lysolipid in the membrane. We hypothesize that micelle-forming membrane components stabilize the rim of bilayer openings and membrane discs that form when liposomes are cycled through TC.
Duke Scholars
Published In
Biochimica et biophysica acta
DOI
EISSN
1878-2434
ISSN
0006-3002
Publication Date
August 2003
Volume
1614
Issue
2
Start / End Page
135 / 138
Related Subject Headings
- Temperature
- Polyethylene Glycols
- Phase Transition
- Micelles
- Liposomes
- Lipid Bilayers
- Cryoelectron Microscopy
- 51 Physical sciences
- 31 Biological sciences
- 06 Biological Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Ickenstein, L. M., Arfvidsson, M. C., Needham, D., Mayer, L. D., & Edwards, K. (2003). Disc formation in cholesterol-free liposomes during phase transition. Biochimica et Biophysica Acta, 1614(2), 135–138. https://doi.org/10.1016/s0005-2736(03)00196-2
Ickenstein, Ludger M., Maria C. Arfvidsson, David Needham, Lawrence D. Mayer, and Katarina Edwards. “Disc formation in cholesterol-free liposomes during phase transition.” Biochimica et Biophysica Acta 1614, no. 2 (August 2003): 135–38. https://doi.org/10.1016/s0005-2736(03)00196-2.
Ickenstein LM, Arfvidsson MC, Needham D, Mayer LD, Edwards K. Disc formation in cholesterol-free liposomes during phase transition. Biochimica et biophysica acta. 2003 Aug;1614(2):135–8.
Ickenstein, Ludger M., et al. “Disc formation in cholesterol-free liposomes during phase transition.” Biochimica et Biophysica Acta, vol. 1614, no. 2, Aug. 2003, pp. 135–38. Epmc, doi:10.1016/s0005-2736(03)00196-2.
Ickenstein LM, Arfvidsson MC, Needham D, Mayer LD, Edwards K. Disc formation in cholesterol-free liposomes during phase transition. Biochimica et biophysica acta. 2003 Aug;1614(2):135–138.
Published In
Biochimica et biophysica acta
DOI
EISSN
1878-2434
ISSN
0006-3002
Publication Date
August 2003
Volume
1614
Issue
2
Start / End Page
135 / 138
Related Subject Headings
- Temperature
- Polyethylene Glycols
- Phase Transition
- Micelles
- Liposomes
- Lipid Bilayers
- Cryoelectron Microscopy
- 51 Physical sciences
- 31 Biological sciences
- 06 Biological Sciences