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Inflammatory bowel disease following solid organ transplantation.

Publication ,  Journal Article
Hampton, DD; Poleski, MH; Onken, JE
Published in: Clin Immunol
September 2008

Inflammatory bowel disease (IBD) is a T cell driven inflammatory condition of the gut. Following solid organ transplantation (SOT), de novo IBD has been reported despite anti-T cell therapy for the prevention of organ rejection. This paradox is illustrated with a case report, highlighting the difficult diagnostic criteria, the potential role of Damage or Pathogen Associated Molecular Pattern Molecules [DAMPs and PAMPs] that drives aspects of ongoing inflammation within the transplanted organ as well as the intestine, and the therapeutic strategies applied. Recurrent IBD is more common than de novo IBD following transplantation, with cumulative risks ten years after orthotopic liver transplantation of 70% and 30%, respectively. Furthermore, the annual incidence of de novo IBD following solid organ transplantation has been estimated to be 206 cases/100,000 or ten times the expected incidence of IBD in the general population (approximately 20 cases/100,000). The association of IBD with other autoimmune conditions such as primary sclerosing cholangitis and autoimmune hepatitis, both common indications for liver transplantation, may play a contributory role, particularly in view of the observation that IBD is more common following liver transplant than other solid organ transplants. Recurrent IBD following transplant appears to run a more aggressive course than de novo IBD, with a higher proportion requiring colectomy for medically refractory disease. Risk factors that have been associated with development of post-transplant IBD include acute CMV infection and the use of tacrolimus.

Duke Scholars

Published In

Clin Immunol

DOI

EISSN

1521-7035

Publication Date

September 2008

Volume

128

Issue

3

Start / End Page

287 / 293

Location

United States

Related Subject Headings

  • T-Lymphocyte Subsets
  • Postoperative Complications
  • Liver Transplantation
  • Inflammatory Bowel Diseases
  • Immunosuppressive Agents
  • Immunology
  • Humans
  • Hepatitis, Autoimmune
  • Female
  • Cytomegalovirus
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hampton, D. D., Poleski, M. H., & Onken, J. E. (2008). Inflammatory bowel disease following solid organ transplantation. Clin Immunol, 128(3), 287–293. https://doi.org/10.1016/j.clim.2008.06.011
Hampton, Daniel D., Martin H. Poleski, and Jane E. Onken. “Inflammatory bowel disease following solid organ transplantation.Clin Immunol 128, no. 3 (September 2008): 287–93. https://doi.org/10.1016/j.clim.2008.06.011.
Hampton DD, Poleski MH, Onken JE. Inflammatory bowel disease following solid organ transplantation. Clin Immunol. 2008 Sep;128(3):287–93.
Hampton, Daniel D., et al. “Inflammatory bowel disease following solid organ transplantation.Clin Immunol, vol. 128, no. 3, Sept. 2008, pp. 287–93. Pubmed, doi:10.1016/j.clim.2008.06.011.
Hampton DD, Poleski MH, Onken JE. Inflammatory bowel disease following solid organ transplantation. Clin Immunol. 2008 Sep;128(3):287–293.
Journal cover image

Published In

Clin Immunol

DOI

EISSN

1521-7035

Publication Date

September 2008

Volume

128

Issue

3

Start / End Page

287 / 293

Location

United States

Related Subject Headings

  • T-Lymphocyte Subsets
  • Postoperative Complications
  • Liver Transplantation
  • Inflammatory Bowel Diseases
  • Immunosuppressive Agents
  • Immunology
  • Humans
  • Hepatitis, Autoimmune
  • Female
  • Cytomegalovirus