Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.H.S., Duke University 2005
  • Fellowship, Gastroenterology, Duke University School of Medicine 1990 - 1993
  • Resident, Duke University School of Medicine 1988 - 1990
  • Intern, Duke University School of Medicine 1987 - 1988
  • M.D., The George Washington University 1987
• 

  Previous Appointments & Affiliations

  • Associate Professor of Medicine, Medicine, Gastroenterology, Medicine 2006 - 2008
  • Assistant Professor of Medicine, Medicine, Gastroenterology, Medicine 1998 - 2006
  • Assistant Clinical Professor of Medicine, Medicine, Gastroenterology, Medicine 1995 - 1998
  • Associate in the Department of Medicine, Medicine, Gastroenterology, Medicine 1993 - 1995
• Research
• 

  Selected Grants

  • A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Efficacy and Safety of Oral Etrasimod as Induction Therapy in Subjects with Moderately to Severely Active Crohn's Disease awarded by Arena Pharmaceuticals, Inc. 2020 - 2025
  • A Phase 3, Randomized, Double-Blind, Placebo-Controlled, 52-Week Study to Assess the Efficacy and Safety of Etrasimod in Subjects with Moderately to Severely Active Ulcerative Colitis awarded by Arena Pharmaceuticals, Inc. 2021 - 2024
  • An Open-Label Extension Study of Etrasimod in Subjects with Moderately to Severely Active Ulcerative Colitis ELEVATE UC OLE: An Open-Label Extension Study for Treatment of Moderately to Severely Active Ulcerative Colitis awarded by Arena Pharmaceuticals, Inc. 2020 - 2023
  • A Phase 1, Open-label, Drug Interaction Study to Evaluate the Effect of Ustekinumab on Cytochrome P450 Enzyme Activities Following Induction and Maintenance Dosing in Participants with Moderate to Severe Crohn's Disease awarded by Janssen Research & Development, LLC 2018 - 2023
  • DG29 SERES awarded by Seres Therapeutics, Inc 2019 - 2021
  • Boehringer Ingelheim Pharmaceuticals Inc - Industry - BI 655130 in Ulcerative Colitis Subjects awarded by Boehringer Ingelheim Corporation 2019 - 2020
  • GS-US-326-1100 Dr. Onken Study awarded by Gilead Sciences, Inc. 2015 - 2017
  • The Role of NAG-1 in Inflammatory Bowel Disease awarded by National Institute of Environmental Health Sciences 2008 - 2010
  • Bromelain-Based Biological Therapy for IBD awarded by National Institutes of Health 2004 - 2007
• 

  External Relationships

  • American Board of Internal Medicine
  • American Gastroenterological Association (AGA)
  • Arena Pharmaceuticals
  • Janssen Pharmaceuticals (Johnson & Johnson)
  • Schering-Plough Corp. (owned by Merck & Co, USA)
  • Seres
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Onken, Jane, Lin Chang, and Fasiha Kanwal. “Reply.” Clin Gastroenterol Hepatol 20, no. 3 (March 2022): 714–15. https://doi.org/10.1016/j.cgh.2021.06.002.
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    • Onken, J. “Issue Highlights.” Clinical Gastroenterology and Hepatology 20, no. 2 (February 1, 2022): 251. https://doi.org/10.1016/j.cgh.2021.11.027.
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    • Shah, Brijen J., Jane E. Onken, Laura Edgar, Janice H. Jou, Keith L. Obstein, Darrell S. Pardi, Seth Richter, et al. “Development of gastroenterology and transplant hepatology milestones 2.0: a guide for programs, faculty, and fellows.” Gastrointest Endosc 94, no. 4 (October 2021): 665–70. https://doi.org/10.1016/j.gie.2021.04.019.
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    • Shah, Brijen J., Jane E. Onken, Laura Edgar, Janice H. Jou, Keith L. Obstein, Darrell S. Pardi, Seth Richter, et al. “Development of Gastroenterology and Transplant Hepatology Milestones 2.0: A Guide for Programs, Faculty, and Fellows.” Gastroenterology 161, no. 4 (October 2021): 1318–24. https://doi.org/10.1053/j.gastro.2021.07.040.
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    • Shah, Brijen J., Jane E. Onken, Laura Edgar, Janice H. Jou, Keith L. Obstein, Darrell S. Pardi, Seth Richter, et al. “Development of gastroenterology and transplant hepatology milestones 2.0: a guide for programs, faculty, and fellows.” Am J Gastroenterol 116, no. 10 (October 1, 2021): 2009–13. https://doi.org/10.14309/ajg.0000000000001490.
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    • Shah, Brijen J., Jane E. Onken, Laura Edgar, Janice H. Jou, Keith L. Obstein, Darrell S. Pardi, Seth Richter, et al. “Development of Gastroenterology and Transplant Hepatology Milestones 2.0: A Guide For Programs, Faculty, and Fellows.” Hepatology 74, no. 4 (October 2021): 2226–32. https://doi.org/10.1002/hep.32097.
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    • Onken, Jane, Lin Chang, and Fasiha Kanwal. “Unconscious Bias in Peer Review.” Clin Gastroenterol Hepatol 19, no. 3 (March 2021): 419–20. https://doi.org/10.1016/j.cgh.2020.12.001.
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    • Onken, J. “Issue Highlights.” Clinical Gastroenterology and Hepatology 19, no. 1 (January 1, 2021): 1–4. https://doi.org/10.1016/j.cgh.2020.11.013.
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    • Onken, Jane. “Education and Trainee Perspectives Section.” Clin Gastroenterol Hepatol 19, no. 1 (January 2021): 5. https://doi.org/10.1016/j.cgh.2020.10.047.
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    • Onken, J. “Issue Highlights.” Clinical Gastroenterology and Hepatology 17, no. 13 (December 1, 2019): 2627–29. https://doi.org/10.1016/j.cgh.2019.10.032.
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    • Onken, J. “Issue Highlights.” Clinical Gastroenterology and Hepatology 16, no. 12 (December 1, 2018): 1843–46. https://doi.org/10.1016/j.cgh.2018.10.022.
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    • Lichtenstein, Gary R., and Jane E. Onken. “Improved Hemoglobin Response with Ferric Carboxymaltose in Patients with Gastrointestinal-Related Iron-Deficiency Anemia Versus Oral Iron.” Dig Dis Sci 63, no. 11 (November 2018): 3009–19. https://doi.org/10.1007/s10620-018-5204-3.
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    • Onken, J. “Issue Highlights.” Clinical Gastroenterology and Hepatology 15, no. 11 (November 1, 2017): 1645–46. https://doi.org/10.1016/j.cgh.2017.09.001.
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    • Sandborn, W. J., B. R. Bhandari, R. Fogel, J. Onken, E. Yen, X. Zhao, Z. Jiang, et al. “Randomised clinical trial: a phase 1, dose-ranging study of the anti-matrix metalloproteinase-9 monoclonal antibody GS-5745 versus placebo for ulcerative colitis.” Aliment Pharmacol Ther 44, no. 2 (July 2016): 157–69. https://doi.org/10.1111/apt.13653.
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    • Regueiro, Miguel, Brian G. Feagan, Bin Zou, Jewel Johanns, Marion A. Blank, Marc Chevrier, Scott Plevy, et al. “Infliximab Reduces Endoscopic, but Not Clinical, Recurrence of Crohn's Disease After Ileocolonic Resection.” Gastroenterology 150, no. 7 (June 2016): 1568–78. https://doi.org/10.1053/j.gastro.2016.02.072.
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    • Roe, Matthew T., Derek D. Cyr, Debra Eckart, Phillip J. Schulte, Michael A. Morse, Kimberly L. Blackwell, Neal E. Ready, et al. “Ascertainment, classification, and impact of neoplasm detection during prolonged treatment with dual antiplatelet therapy with prasugrel vs. clopidogrel following acute coronary syndrome.” Eur Heart J 37, no. 4 (January 21, 2016): 412–22. https://doi.org/10.1093/eurheartj/ehv611.
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    • Rose, Suzanne, Brijen J. Shah, Jane Onken, Arthur J. DeCross, Maura H. Davis, Rajeev Jain, Lawrence S. Kim, Kim Persley, Sheryl A. Pfeil, and Lori N. Marks. “Bridging the G-APP: Continuous Professional Development for Gastroenterologists: Replacing MOC with a Model for Lifelong Learning and Accountability.” Clin Gastroenterol Hepatol, August 19, 2015. https://doi.org/10.1016/j.cgh.2015.08.016.
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    • Rose, Suzanne, Brijen J. Shah, Jane Onken, Arthur J. DeCross, Maura H. Davis, Rajeev Jain, Lawrence S. Kim, Kim Persley, Sheryl A. Pfeil, and Lori N. Marks. “Bridging the G-APP: Continuous Professional Development for Gastroenterologists: Replacing MOC with a Model for Lifelong Learning and Accountability.” Gastroenterology, August 19, 2015. https://doi.org/10.1053/j.gastro.2015.08.009.
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    • Onken, Jane E., and Arthur J. DeCross. “The education and training committee: at work for the AGA membership.” Gastroenterology 147, no. 5 (November 2014): 948–51. https://doi.org/10.1053/j.gastro.2014.09.022.
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    • Oversight Working Network, Robert E., Suzanne Rose, Oren K. Fix, Brijen J. Shah, Tamara N. Jones, Ronald D. Szyjkowski, Brian P. Bosworth, et al. “Entrustable professional activities for gastroenterology fellowship training.” Gastrointest Endosc 80, no. 1 (July 2014): 16–27. https://doi.org/10.1016/j.gie.2014.05.302.
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    • Onken, Jane E., David B. Bregman, Robert A. Harrington, David Morris, John Buerkert, Douglas Hamerski, Hussain Iftikhar, et al. “Ferric carboxymaltose in patients with iron-deficiency anemia and impaired renal function: the REPAIR-IDA trial.” Nephrol Dial Transplant 29, no. 4 (April 2014): 833–42. https://doi.org/10.1093/ndt/gft251.
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    • Onken, Jane E., David B. Bregman, Robert A. Harrington, David Morris, Peter Acs, Bruce Akright, Charles Barish, et al. “A multicenter, randomized, active-controlled study to investigate the efficacy and safety of intravenous ferric carboxymaltose in patients with iron deficiency anemia.” Transfusion 54, no. 2 (February 2014): 306–15. https://doi.org/10.1111/trf.12289.
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    • Roe, Matthew T., Paul W. Armstrong, Keith A. A. Fox, Harvey D. White, Dorairaj Prabhakaran, Shaun G. Goodman, Jan H. Cornel, et al. “Prasugrel versus clopidogrel for acute coronary syndromes without revascularization.” N Engl J Med 367, no. 14 (October 4, 2012): 1297–1309. https://doi.org/10.1056/NEJMoa1205512.
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    • Szczech, Lynda A., David B. Bregman, Robert A. Harrington, David Morris, Angelia Butcher, Todd A. Koch, Lawrence T. Goodnough, Myles Wolf, and Jane E. Onken. “Randomized evaluation of efficacy and safety of ferric carboxymaltose in patients with iron deficiency anaemia and impaired renal function (REPAIR-IDA): rationale and study design.” Nephrol Dial Transplant 25, no. 7 (July 2010): 2368–75. https://doi.org/10.1093/ndt/gfq218.
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    • Onken, Jane E. “Is colorectal cancer surveillance cost-effective in patients with ulcerative colitis?” Inflamm Bowel Dis 14 Suppl 2 (October 2008): S196–97. https://doi.org/10.1002/ibd.20613.
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    • Hampton, Daniel D., Martin H. Poleski, and Jane E. Onken. “Inflammatory bowel disease following solid organ transplantation.” Clin Immunol 128, no. 3 (September 2008): 287–93. https://doi.org/10.1016/j.clim.2008.06.011.
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    • Onken, Jane E., Paula K. Greer, Brian Calingaert, and Laura P. Hale. “Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro.” Clin Immunol 126, no. 3 (March 2008): 345–52. https://doi.org/10.1016/j.clim.2007.11.002.
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    • Micames, Carlos G., Rex Bentley, and Jane Onken. “Clinical challenges and images in GI. Invasive candidal enterocolitis.” Gastroenterology 133, no. 2 (August 2007): 391–731. https://doi.org/10.1053/j.gastro.2007.06.051.
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    • Arseneau, Kristen O., Shahnaz Sultan, Dawn T. Provenzale, Jane Onken, Stephen J. Bickston, Eugene Foley, Alfred F. Connors, and Fabio Cominelli. “Do patient preferences influence decisions on treatment for patients with steroid-refractory ulcerative colitis?” Clin Gastroenterol Hepatol 4, no. 9 (September 2006): 1135–42. https://doi.org/10.1016/j.cgh.2006.05.003.
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    • Hampton, D., and J. E. Onken. “Pulmonary eosinophilia following infliximab treatment for Crohn's disease: Review.” Gastroenterology and Hepatology 2, no. 8 (August 1, 2006): 597.
    • Hampton, Daniel, and Jane E. Onken. “Review.” Gastroenterol Hepatol (N Y) 2, no. 8 (August 2006): 597.
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    • Provenzale, Dawn, and Jane E. Onken. “TPMT genotype screening for patients about to begin azathioprine treatment--a look at costs and potential benefits.” Inflamm Bowel Dis 11, no. 12 (December 2005): 1119–20. https://doi.org/10.1097/01.mib.0000186491.43191.0e.
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    • Emmons, Karen M., Colleen M. McBride, Elaine Puleo, Kathryn I. Pollak, Elizabeth Clipp, Karen Kuntz, Bess H. Marcus, et al. “Project PREVENT: a randomized trial to reduce multiple behavioral risk factors for colon cancer.” Cancer Epidemiol Biomarkers Prev 14, no. 6 (June 2005): 1453–59. https://doi.org/10.1158/1055-9965.EPI-04-0620.
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    • Emmons, Karen M., Colleen M. McBride, Elaine Puleo, Kathryn I. Pollak, Bess H. Marcus, Melissa Napolitano, Elizabeth Clipp, Jane Onken, Francis A. Farraye, and Robert Fletcher. “Prevalence and predictors of multiple behavioral risk factors for colon cancer.” Prev Med 40, no. 5 (May 2005): 527–34. https://doi.org/10.1016/j.ypmed.2004.10.001.
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    • Sands, Bruce E., Carmen Cuffari, Jeffry Katz, Subra Kugathasan, Jane Onken, Charles Vitek, and Walter Orenstein. “Guidelines for immunizations in patients with inflammatory bowel disease.” Inflamm Bowel Dis 10, no. 5 (September 2004): 677–92. https://doi.org/10.1097/00054725-200409000-00028.
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    • Clipp, Elizabeth C., Elizabeth H. Carver, Kathryn I. Pollak, Elaine Puleo, Karen M. Emmons, Jane Onken, Francis A. Farraye, and Colleen M. McBride. “Age-related vulnerabilities of older adults with colon adenomas: evidence from Project Prevent.” Cancer 100, no. 5 (March 1, 2004): 1085–94. https://doi.org/10.1002/cncr.20082.
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    • Sands, Bruce E., Frank H. Anderson, Charles N. Bernstein, William Y. Chey, Brian G. Feagan, Richard N. Fedorak, Michael A. Kamm, et al. “Infliximab maintenance therapy for fistulizing Crohn's disease.” N Engl J Med 350, no. 9 (February 26, 2004): 876–85. https://doi.org/10.1056/NEJMoa030815.
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    • Bloomfeld, R. S., and J. E. Onken. “Mercaptopurine metabolite results in clinical gastroenterology practice.” Aliment Pharmacol Ther 17, no. 1 (January 2003): 69–73. https://doi.org/10.1046/j.1365-2036.2003.01392.x.
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    • Onken, Jane E., Joëlle Y. Friedman, Sujha Subramanian, Kevin P. Weinfurt, Shelby D. Reed, Joshua H. Malenbaum, Troy Schmidt, and Kevin A. Schulman. “Treatment patterns and costs associated with sessile colorectal polyps.” Am J Gastroenterol 97, no. 11 (November 2002): 2896–2901. https://doi.org/10.1111/j.1572-0241.2002.07058.x.
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    • Hanauer, S. B., B. G. Feagan, G. R. Lichtenstein, and J. E. Onken. “Maintaining remission in Crohn's Disease.” Evidence Based Gastroenterology 3, no. 3 (August 1, 2002): 99–101. https://doi.org/10.1097/00132579-200208000-00013.
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    • Bloomfeld, Richard S., and Jane E. Onken. “6-Mercaptopurine (6MP) metabolite measurements from the clinics: The first year of widespread availability.” Gastroenterology 120, no. 5 (April 2001): A626–A626. https://doi.org/10.1016/s0016-5085(08)83114-9.
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    • Provenzale, D., and J. Onken. “Surveillance issues in inflammatory bowel disease: ulcerative colitis.” J Clin Gastroenterol 32, no. 2 (February 2001): 99–105. https://doi.org/10.1097/00004836-200102000-00003.
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    • Muir, Andrew J., Dawn Provenzale, and Jane E. Onken. “Fistulous complications in Crohn's disease: Impact on health related quality of life (HRQL) and resource utilization.” Gastroenterology 118, no. 4 (April 2000): A585–A585. https://doi.org/10.1016/s0016-5085(00)84477-7.
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    • Onken, J. E., B. Sands, R. Hogezand, G. Haens, T. Braakman, K. DeWoody, T. Schaible, et al. “Consistent treatment benefit with infliximab in patients with fistulizing Crohn's disease.” Gastroenterology 116, no. 4 (April 1, 1999): A788–A788.
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    • Eloubeidi, M. A., and J. E. Onken. “Manifestations of Crohn's disease.” Dig Dis 16, no. 4 (July 1998): 262. https://doi.org/10.1159/000016874.
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    • Provenzale, D., J. B. Wong, J. E. Onken, and J. Lipscomb. “Performing a cost-effectiveness analysis: surveillance of patients with ulcerative colitis.” Am J Gastroenterol 93, no. 6 (June 1998): 872–80. https://doi.org/10.1111/j.1572-0241.1998.00314.x.
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    • Provenzale, D., M. Shearin, J. E. Onken, and J. B. Wong. “Surveillance with colectomy for low grade dysplasia increases length and quality of life in ulcerative colitis patients and is cost-effective compared with common medical practices.” Gastroenterology 114 (April 1998): A35–A35. https://doi.org/10.1016/s0016-5085(98)80142-x.
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    • Ciaccia, D., F. Gress, J. E. Onken, J. Feczko, J. Chappo, and G. Lehman. “Endoscopic ultrasound characteristics in chronic pancreatitis.” Gastrointestinal Endoscopy 45, no. 4 (April 1, 1997): 582–582.
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    • Davis, W. Z., P. B. Cotton, R. Arias, D. Williams, and J. E. Onken. “ERCP and sphincterotomy in the context of laparoscopic cholecystectomy: academic and community practice patterns and results.” Am J Gastroenterol 92, no. 4 (April 1997): 597–601.
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    • Onken, J. E., D. Ciaccia, J. T. Garbutt, and T. L. Ortel. “Activated protein C resistance (APCR) phenotype in patients with inflammatory bowel disease.” Gastroenterology 112, no. 4 (April 1, 1997): A1056–A1056.
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    • Ciaccia, D., J. Onken, J. Chappo, S. Sherman, G. Lehman, and F. Gress. “Endoscopic ultrasound guided fine needle aspiration in the diagnosis of chronic pancreatitis (CP).” Gastrointestinal Endoscopy 45, no. 4 (January 1, 1997). https://doi.org/10.1016/S0016-5107(97)80582-2.
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    • Jowell, P. S., G. Eisen, J. Onken, B. P. Bute, and B. Ginsberg. “Patient-controlled analgesia for conscious sedation during endoscopic retrograde cholangiopancreatography: a randomized controlled trial.” Gastrointest Endosc 43, no. 5 (May 1996): 490–94. https://doi.org/10.1016/s0016-5107(96)70292-4.
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    • Bouras, E. P., K. M. McGrath, D. Ciaccia, and J. E. Onken. “Correlation of common bile duct diameter by ultrasound and cholangiography.” Gastrointestinal Endoscopy 43, no. 4 (April 1, 1996): 337–337.
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    • Onken, J. E., S. R. Brazer, G. M. Eisen, D. M. Williams, E. P. Bouras, E. R. DeLong, T. T. Long, F. S. Pancotto, D. L. Rhodes, and P. B. Cotton. “Predicting the presence of choledocholithiasis in patients with symptomatic cholelithiasis.” Am J Gastroenterol 91, no. 4 (April 1996): 762–67.
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    • Provenzale, D., J. E. Onken, and J. B. Wong. “Prophylactic colectomy or surveillance for patients with ulcerative colitis - A cost-effectiveness analysis.” Gastroenterology 110, no. 4 (April 1, 1996): A34–A34.
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    • Bouras, E. P., K. M. McGrath, D. Ciaccia, and J. E. Onken. “Correlation of common bile duct diameter by ultrasound and cholangiography.” Gastrointestinal Endoscopy 43, no. 4 (January 1, 1996): 375. https://doi.org/10.1016/S0016-5107(96)80338-5.
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    • Strobel, J., M. Eloubeidi, and J. Onken. “Clinical factors predicting good outcome in upper gastrointestinal bleeding.” Gastrointestinal Endoscopy 43, no. 4 (January 1, 1996): 321. https://doi.org/10.1016/S0016-5107(96)80123-4.
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    • Onken, J. E., E. P. Bouras, D. M. Williams, and S. R. Brazer. “Liver test patterns as predictors of choledocholithiasis.” Gastrointestinal Endoscopy 41, no. 4 (April 1995): 409–409. https://doi.org/10.1016/s0016-5107(05)80490-0.
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    • Brazer, S. R., J. E. Onken, C. B. Dalton, J. W. Smith, and S. S. Schiffman. “Effect of different coffees on esophageal acid contact time and symptoms in coffee-sensitive subjects.” Physiol Behav 57, no. 3 (March 1995): 563–67. https://doi.org/10.1016/0031-9384(94)00363-a.
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    • Onken, J. E., and S. R. Brazer. “Clinical trials. How should they be designed?” Gastrointest Endosc Clin N Am 4, no. 2 (April 1994): 423–34.
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    • BRAZER, S. R., J. E. ONKEN, C. B. DALTON, J. W. SMITH, and S. S. SCHIFFMAN. “THE EFFECT OF DIFFERENT COFFEES ON ESOPHAGEAL ACID CONTACT TIME (EACT), HEARTBURN (HB) AND REGURGITATION (RG) IN COFFEE-SENSITIVE SUBJECTS.” Gastroenterology 104, no. 4 (April 1, 1993): A45–A45.
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    • ONKEN, J. E., S. R. BRAZER, F. S. PANCOTTO, T. T. LONG, D. F. RHODES, and P. B. COTTON. “PREDICTION OF CHOLEDOCHOLITHIASIS.” Gastroenterology 104, no. 4 (April 1, 1993): A19–A19.
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    • Onken, J. E., and J. Baillie. “A prospective study of esophageal squamous cell carcinoma in achalasia.” Gastrointest Endosc 38, no. 6 (November 1992): 738–39. https://doi.org/10.1016/s0016-5107(92)70596-3.
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    • Onken, J. E., T. Pappas, and J. Baillie. “Long term results of choledochoduodenostomy in the treatment of choledocholithiasis.” Gastrointest Endosc 38, no. 3 (May 1992): 403–5. https://doi.org/10.1016/s0016-5107(92)70459-3.
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  • Conference Papers

    • Fasanya-Uptagraft, Helen, Jeffrey Basile, Ashley Lane, Harold J. Boutte, and Jane E. Onken. “Outcomes of Inflammatory Bowel Disease After Organ Transplantation (Solid Organ or Hematopoietic Stem Cell Transplantation).” In Gastroenterology, 146:S445–S445. W B SAUNDERS CO-ELSEVIER INC, 2014.
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    • Lichtenstein, Gary R., Andy He, B. Hanauer, Satish Keshav, and Jane E. Onken. “Ferric Carboxymaltose: Efficacy and Safety in Patients With Gastrointestinal-Related Iron Deficiency Anemia: A Pooled Analysis.” In Gastroenterology, 146:S369–S369. W B SAUNDERS CO-ELSEVIER INC, 2014.
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    • Hale, L. P., M. R. Gottfried, and J. E. Onken. “Bromelain treatment of inflammatory bowel disease.” In Gastroenterology, 126:A286–87. W B SAUNDERS CO, 2004.
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    • Parent, J., M. S. Branch, P. S. Jowell, J. Affronti, J. Onken, T. Pappas, and J. Baillie. “Predictors of improvement following endoscopic management of chronic pancreatitis.” In Gastrointestinal Endoscopy, 43:411-, 1996.

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