Jane Elizabeth Onken | Scholars@Duke

Jane Elizabeth Onken
Associate Professor of Medicine

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Gastroenterology, Medicine 2008
Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2003

Contact Information

03137C Hosp South, Durham, NC 27710
Duke Box 3902, Durham, NC 27710
onken001@mc.duke.edu (919) 684-1817

Background
Education, Training, & Certifications
- M.H.S., Duke University 2005
- Fellowship, Gastroenterology, Duke University School of Medicine 1990 - 1993
- Resident, Duke University School of Medicine 1988 - 1990
- Intern, Duke University School of Medicine 1987 - 1988
- M.D., George Washington University 1987
Duke Appointment History
- Associate Professor of Medicine, Medicine, Gastroenterology, Medicine 2006 - 2008
- Assistant Professor of Medicine, Medicine, Gastroenterology, Medicine 1998 - 2006
- Assistant Clinical Professor of Medicine, Medicine, Gastroenterology, Medicine 1995 - 1998
- Associate in the Department of Medicine, Medicine, Gastroenterology, Medicine 1993 - 1995
Research
Selected Grants
- Moderate to Severe Crohn's Disease awarded by Janssen Research & Development, LLC 2018 - 2022
- GS-US-326-1100 Dr. Onken Study awarded by Gilead Sciences, Inc. 2015 - 2017
- The Role of NAG-1 in Inflammatory Bowel Disease awarded by National Institute of Environmental Health Sciences 2008 - 2010
- Bromelain as a Biologically-Based Therapy for IBD awarded by National Institutes of Health 2004 - 2007
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Fasanya-Uptagraft, H, Basile, J, Lane, A, Boutte, HJ, and Onken, JE. "Outcomes of Inflammatory Bowel Disease After Organ Transplantation (Solid Organ or Hematopoietic Stem Cell Transplantation)." May 2014. Link to Item
  - Lichtenstein, GR, He, A, Hanauer, B, Keshav, S, and Onken, JE. "Ferric Carboxymaltose: Efficacy and Safety in Patients With Gastrointestinal-Related Iron Deficiency Anemia: A Pooled Analysis." May 2014. Link to Item
  - Hale, LP, Gottfried, MR, and Onken, JE. "Bromelain treatment of inflammatory bowel disease." April 2004. Link to Item
  - Parent, J, Branch, MS, Jowell, PS, Affronti, J, Onken, J, Pappas, T, and Baillie, J. "Predictors of improvement following endoscopic management of chronic pancreatitis." 1996.
- Journal Articles
  - Lichtenstein, GR, and Onken, JE. "Improved Hemoglobin Response with Ferric Carboxymaltose in Patients with Gastrointestinal-Related Iron-Deficiency Anemia Versus Oral Iron." Digestive Diseases and Sciences (July 28, 2018). Full Text
  - Sandborn, WJ, Bhandari, BR, Fogel, R, Onken, J, Yen, E, Zhao, X, Jiang, Z, Ge, D, Xin, Y, Ye, Z, French, D, Silverman, JA, Kanwar, B, Subramanian, GM, McHutchison, JG, Lee, SD, Shackelton, LM, Pai, RK, Levesque, BG, and Feagan, BG. "Randomised clinical trial: a phase 1, dose-ranging study of the anti-matrix metalloproteinase-9 monoclonal antibody GS-5745 versus placebo for ulcerative colitis." Alimentary pharmacology & therapeutics 44, no. 2 (July 2016): 157-169. Full Text
  - Regueiro, M, Feagan, BG, Zou, B, Johanns, J, Blank, MA, Chevrier, M, Plevy, S, Popp, J, Cornillie, FJ, Lukas, M, Danese, S, Gionchetti, P, Hanauer, SB, Reinisch, W, Sandborn, WJ, Sorrentino, D, Rutgeerts, P, and PREVENT Study Group, . "Infliximab Reduces Endoscopic, but Not Clinical, Recurrence of Crohn's Disease After Ileocolonic Resection." Gastroenterology 150, no. 7 (June 2016): 1568-1578. Full Text
  - Roe, MT, Cyr, DD, Eckart, D, Schulte, PJ, Morse, MA, Blackwell, KL, Ready, NE, Zafar, SY, Beaven, AW, Strickler, JH, Onken, JE, Winters, KJ, Houterloot, L, Zamoryakhin, D, Wiviott, SD, White, HD, Prabhakaran, D, Fox, KAA, Armstrong, PW, Ohman, EM, and TRILOGY ACS Investigators, . "Ascertainment, classification, and impact of neoplasm detection during prolonged treatment with dual antiplatelet therapy with prasugrel vs. clopidogrel following acute coronary syndrome." European Heart Journal 37, no. 4 (January 2016): 412-422. Full Text
  - Rose, S, Shah, BJ, Onken, J, DeCross, AJ, Davis, MH, Jain, R, Kim, LS, Persley, K, Pfeil, SA, and Marks, LN. "Bridging the G-APP: Continuous Professional Development for Gastroenterologists: Replacing MOC with a Model for Lifelong Learning and Accountability." Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association (August 19, 2015). Full Text
  - Rose, S, Shah, BJ, Onken, J, DeCross, AJ, Davis, MH, Jain, R, Kim, LS, Persley, K, Pfeil, SA, and Marks, LN. "Bridging the G-APP: Continuous Professional Development for Gastroenterologists: Replacing MOC with a Model for Lifelong Learning and Accountability." Gastroenterology (August 19, 2015). Full Text
  - Onken, JE, and DeCross, AJ. "The education and training committee: at work for the AGA membership." Gastroenterology 147, no. 5 (November 2014): 948-951. Full Text
  - Oversight Working Network, , Rose, S, Fix, OK, Shah, BJ, Jones, TN, Szyjkowski, RD, Bosworth, BP, Bull-Henry, K, Coyle, W, Gyawali, CP, Koteish, A, Onken, J, Pandolfino, J, Pardi, D, Reddy, G, Richter, S, Savides, TJ, Sedlack, RE, American Association for the Study of Liver Diseases (AASLD), , American College of Gastroenterology (ACG), , American Gastroenterological Association (AGA), , and American Neurogastroenterology and Motility Society (ANMS), et al. "Entrustable professional activities for gastroenterology fellowship training." Gastrointestinal endoscopy 80, no. 1 (July 2014): 16-27. Full Text
  - Onken, JE, Bregman, DB, Harrington, RA, Morris, D, Buerkert, J, Hamerski, D, Iftikhar, H, Mangoo-Karim, R, Martin, ER, Martinez, CO, Newman, GE, Qunibi, WY, Ross, DL, Singh, B, Smith, MT, Butcher, A, Koch, TA, and Goodnough, LT. "Ferric carboxymaltose in patients with iron-deficiency anemia and impaired renal function: the REPAIR-IDA trial." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association European Renal Association 29, no. 4 (April 2014): 833-842. Full Text
  - Onken, JE, Bregman, DB, Harrington, RA, Morris, D, Acs, P, Akright, B, Barish, C, Bhaskar, BS, Smith-Nguyen, GN, Butcher, A, Koch, TA, and Goodnough, LT. "A multicenter, randomized, active-controlled study to investigate the efficacy and safety of intravenous ferric carboxymaltose in patients with iron deficiency anemia." Transfusion 54, no. 2 (February 1, 2014): 306-315. Full Text
  - Onken, JE, Bregman, DB, Harrington, RA, Morris, D, Acs, P, Akright, B, Barish, C, Bhaskar, BS, Smith-Nguyen, GN, Butcher, A, Koch, TA, and Goodnough, LT. "A multicenter, randomized, active-controlled study to investigate the efficacy and safety of intravenous ferric carboxymaltose in patients with iron deficiency anemia." Transfusion 54, no. 2 (February 2014): 306-315. Full Text Link to Item
  - Szczech, LA, Bregman, DB, Harrington, RA, Morris, D, Butcher, A, Koch, TA, Goodnough, LT, Wolf, M, and Onken, JE. "Randomized evaluation of efficacy and safety of ferric carboxymaltose in patients with iron deficiency anaemia and impaired renal function (REPAIR-IDA): rationale and study design." Nephrol Dial Transplant 25, no. 7 (July 2010): 2368-2375. Full Text Link to Item
  - Onken, JE. "Is colorectal cancer surveillance cost-effective in patients with ulcerative colitis?." Inflamm Bowel Dis 14 Suppl 2 (October 2008): S196-S197. Full Text Link to Item
  - Hampton, DD, Poleski, MH, and Onken, JE. "Inflammatory bowel disease following solid organ transplantation." Clin Immunol 128, no. 3 (September 2008): 287-293. Full Text Link to Item
  - Onken, JE, Greer, PK, Calingaert, B, and Hale, LP. "Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro." Clin Immunol 126, no. 3 (March 2008): 345-352. Full Text Link to Item
  - Micames, CG, Bentley, R, and Onken, J. "Clinical challenges and images in GI. Invasive candidal enterocolitis." Gastroenterology 133, no. 2 (August 2007): 391-731. Full Text
  - Arseneau, KO, Sultan, S, Provenzale, DT, Onken, J, Bickston, SJ, Foley, E, Connors, AF, and Cominelli, F. "Do patient preferences influence decisions on treatment for patients with steroid-refractory ulcerative colitis?." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association 4, no. 9 (September 2006): 1135-1142. Full Text
  - Hampton, D, and Onken, JE. "Review." Gastroenterology & Hepatology 2, no. 8 (August 2006): 597-null. (Review)
  - Hampton, D, and Onken, JE. "Pulmonary eosinophilia following infliximab treatment for Crohn's disease: Review." Gastroenterology and Hepatology 2, no. 8 (2006): 597--.
  - Provenzale, D, and Onken, JE. "TPMT genotype screening for patients about to begin azathioprine treatment--a look at costs and potential benefits." Inflamm Bowel Dis 11, no. 12 (December 2005): 1119-1120. Link to Item
  - Emmons, KM, McBride, CM, Puleo, E, Pollak, KI, Clipp, E, Kuntz, K, Marcus, BH, Napolitano, M, Onken, J, Farraye, F, and Fletcher, R. "Project PREVENT: a randomized trial to reduce multiple behavioral risk factors for colon cancer." Cancer Epidemiol Biomarkers Prev 14, no. 6 (June 2005): 1453-1459. Full Text Link to Item
  - Emmons, KM, McBride, CM, Puleo, E, Pollak, KI, Marcus, BH, Napolitano, M, Clipp, E, Onken, J, Farraye, FA, and Fletcher, R. "Prevalence and predictors of multiple behavioral risk factors for colon cancer." Prev Med 40, no. 5 (May 2005): 527-534. Full Text Link to Item
  - Clipp, EC, Carver, EH, Pollak, KI, Puleo, E, Emmons, KM, Onken, J, Farraye, FA, and McBride, CM. "Age-related vulnerabilities of older adults with colon adenomas: evidence from Project Prevent." Cancer 100, no. 5 (March 1, 2004): 1085-1094. Full Text Link to Item
  - Sands, BE, Anderson, FH, Bernstein, CN, Chey, WY, Feagan, BG, Fedorak, RN, Kamm, MA, Korzenik, JR, Lashner, BA, Onken, JE, Rachmilewitz, D, Rutgeerts, P, Wild, G, Wolf, DC, Marsters, PA, Travers, SB, Blank, MA, and van Deventer, SJ. "Infliximab maintenance therapy for fistulizing Crohn's disease." The New England Journal of Medicine 350, no. 9 (February 2004): 876-885. Full Text
  - Sands, BE, Cuffari, C, Katz, J, Kugathasan, S, Onken, J, Vitek, C, and Orenstein, W. "Guidelines for immunizations in patients with inflammatory bowel disease." Inflammatory Bowel Diseases 10, no. 5 (2004): 677-692. Full Text
  - Bloomfeld, RS, and Onken, JE. "Mercaptopurine metabolite results in clinical gastroenterology practice." Aliment Pharmacol Ther 17, no. 1 (January 2003): 69-73. Link to Item
  - Onken, JE, Friedman, JY, Subramanian, S, Weinfurt, KP, Reed, SD, Malenbaum, JH, Schmidt, T, and Schulman, KA. "Treatment patterns and costs associated with sessile colorectal polyps." Am J Gastroenterol 97, no. 11 (November 2002): 2896-2901. Full Text Link to Item
  - Hanauer, SB, Feagan, BG, Lichtenstein, GR, and Onken, JE. "Maintaining remission in Crohn's Disease." Evidence-Based Gastroenterology 3, no. 3 (2002): 99-101. Full Text
  - Bloomfeld, RS, and Onken, JE. "6-mercaptopurine (6MP) metabolite measurements from the clinics: The first year of widespread availability." GASTROENTEROLOGY 120, no. 5 (April 2001): A626-A626. Link to Item
  - Provenzale, D, and Onken, J. "Surveillance issues in inflammatory bowel disease: ulcerative colitis." J Clin Gastroenterol 32, no. 2 (February 2001): 99-105. Link to Item
  - Muir, AJ, Provenzale, D, and Onken, JE. "Fistulous complications in Crohn's disease: Impact on health related quality of life (HRQL) and resource utilization." GASTROENTEROLOGY 118, no. 4 (April 2000): A585-A585. Full Text Link to Item
  - Onken, JE, Sands, B, Hogezand, R, Haens, G, Braakman, T, DeWoody, K, Schaible, T, Targon, S, Hanauer, S, van Deventer, S, Rutgeerts, P, and Present, D. "Consistent treatment benefit with infliximab in patients with fistulizing Crohn's disease." GASTROENTEROLOGY 116, no. 4 (April 1999): A788-A788. Link to Item
  - Eloubeidi, MA, and Onken, JE. "Manifestations of Crohn's disease." Dig Dis 16, no. 4 (July 1998): 262-. Full Text Link to Item
  - Provenzale, D, Wong, JB, Onken, JE, and Lipscomb, J. "Performing a cost-effectiveness analysis: surveillance of patients with ulcerative colitis." Am J Gastroenterol 93, no. 6 (June 1998): 872-880. Full Text Link to Item
  - Provenzale, D, Shearin, M, Onken, JE, and Wong, JB. "Surveillance with colectomy for low grade dysplasia increases length and quality of life in ulcerative colitis patients and is cost-effective compared with common medical practices." GASTROENTEROLOGY 114, no. 4 (April 15, 1998): A35-A35. Full Text Link to Item
  - Ciaccia, D, Gress, F, Onken, JE, Feczko, J, Chappo, J, and Lehman, G. "Endoscopic ultrasound characteristics in chronic pancreatitis." GASTROINTESTINAL ENDOSCOPY 45, no. 4 (April 1997): 582-582. Link to Item
  - Davis, WZ, Cotton, PB, Arias, R, Williams, D, and Onken, JE. "ERCP and sphincterotomy in the context of laparoscopic cholecystectomy: academic and community practice patterns and results." Am J Gastroenterol 92, no. 4 (April 1997): 597-601. Link to Item
  - Onken, JE, Ciaccia, D, Garbutt, JT, and Ortel, TL. "Activated protein C resistance (APCR) phenotype in patients with inflammatory bowel disease." GASTROENTEROLOGY 112, no. 4 (April 1997): A1056-A1056. Link to Item
  - Ciaccia, D, Gress, F, Onken, JE, Feczko, J, Chapppo, J, and Lehman, G. "Endoscopic ultrasound characteristics in chronic pancreatitis." Gastrointestinal Endoscopy 45, no. 4 (1997): AB170-.
  - Ciaccia, D, Onken, J, Chappo, J, Sherman, S, Lehman, G, and Gress, F. "Endoscopic ultrasound guided fine needle aspiration in the diagnosis of chronic pancreatitis (CP)." Gastrointestinal Endoscopy 45, no. 4 (1997): AB170-.
  - Jowell, PS, Eisen, G, Onken, J, Bute, BP, and Ginsberg, B. "Patient-controlled analgesia for conscious sedation during endoscopic retrograde cholangiopancreatography: a randomized controlled trial." Gastrointest Endosc 43, no. 5 (May 1996): 490-494. Link to Item
  - Bouras, EP, McGrath, KM, Ciaccia, D, and Onken, JE. "Correlation of common bile duct diameter by ultrasound and cholangiography." GASTROINTESTINAL ENDOSCOPY 43, no. 4 (April 1996): 337-337. Link to Item
  - Onken, JE, Brazer, SR, Eisen, GM, Williams, DM, Bouras, EP, DeLong, ER, Long, TT, Pancotto, FS, Rhodes, DL, and Cotton, PB. "Predicting the presence of choledocholithiasis in patients with symptomatic cholelithiasis." Am J Gastroenterol 91, no. 4 (April 1996): 762-767. Link to Item
  - Provenzale, D, Onken, JE, and Wong, JB. "Prophylactic colectomy or surveillance for patients with ulcerative colitis - A cost-effectiveness analysis." GASTROENTEROLOGY 110, no. 4 (April 1996): A34-A34. Link to Item
  - Bouras, EP, McGrath, KM, Ciaccia, D, and Onken, JE. "Correlation of common bile duct diameter by ultrasound and cholangiography." Gastrointestinal Endoscopy 43, no. 4 (1996): 375--.
  - Strobel, J, Eloubeidi, M, and Onken, J. "Clinical factors predicting good outcome in upper gastrointestinal bleeding." Gastrointestinal Endoscopy 43, no. 4 (1996): 321--.
  - ONKEN, JE, BOURAS, EP, WILLIAMS, DM, and BRAZER, SR. "LIVER TEST PATTERNS AS PREDICTORS OF CHOLEDOCHOLITHIASIS." GASTROINTESTINAL ENDOSCOPY 41, no. 4 (April 1995): 409-409. Full Text Link to Item
  - Brazer, SR, Onken, JE, Dalton, CB, Smith, JW, and Schiffman, SS. "Effect of different coffees on esophageal acid contact time and symptoms in coffee-sensitive subjects." Physiol Behav 57, no. 3 (March 1995): 563-567. Link to Item
  - Onken, JE, and Brazer, SR. "Clinical trials. How should they be designed?." Gastrointestinal Endoscopy Clinics of North America 4, no. 2 (April 1994): 423-434. (Review) Full Text
  - BRAZER, SR, ONKEN, JE, DALTON, CB, SMITH, JW, and SCHIFFMAN, SS. "THE EFFECT OF DIFFERENT COFFEES ON ESOPHAGEAL ACID CONTACT TIME (EACT), HEARTBURN (HB) AND REGURGITATION (RG) IN COFFEE-SENSITIVE SUBJECTS." GASTROENTEROLOGY 104, no. 4 (April 1993): A45-A45. Link to Item
  - ONKEN, JE, BRAZER, SR, PANCOTTO, FS, LONG, TT, RHODES, DF, and COTTON, PB. "PREDICTION OF CHOLEDOCHOLITHIASIS." GASTROENTEROLOGY 104, no. 4 (April 1993): A19-A19. Link to Item
  - Onken, JE, and Baillie, J. "A prospective study of esophageal squamous cell carcinoma in achalasia." Gastrointest Endosc 38, no. 6 (November 1992): 738-739. Link to Item
  - Onken, JE, Pappas, T, and Baillie, J. "Long term results of choledochoduodenostomy in the treatment of choledocholithiasis." Gastrointest Endosc 38, no. 3 (May 1992): 403-405. Link to Item

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Conference Papers

Journal Articles