Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.H.S., Duke University 2005
  • Fellowship, Gastroenterology, Duke University School of Medicine 1990 - 1993
  • Resident, Duke University School of Medicine 1988 - 1990
  • Intern, Duke University School of Medicine 1987 - 1988
  • M.D., George Washington University 1987
• 

  Duke Appointment History

  • Associate Professor of Medicine, Medicine, Gastroenterology, Medicine 2006 - 2008
  • Assistant Professor of Medicine, Medicine, Gastroenterology, Medicine 1998 - 2006
  • Assistant Clinical Professor of Medicine, Medicine, Gastroenterology, Medicine 1995 - 1998
  • Associate in the Department of Medicine, Medicine, Gastroenterology, Medicine 1993 - 1995
• Research
• 

  Selected Grants

  • Moderate to Severe Crohn's Disease awarded by Janssen Research & Development, LLC 2018 - 2022
  • DG29 SERES awarded by Seres Therapeutics, Inc 2019 - 2020
  • Boehringer Ingelheim Pharmaceuticals Inc - Industry - BI 655130 in Ulcerative Colitis Subjects awarded by Boehringer Ingelheim Corporation 2019
  • GS-US-326-1100 Dr. Onken Study awarded by Gilead Sciences, Inc. 2015 - 2017
  • The Role of NAG-1 in Inflammatory Bowel Disease awarded by National Institute of Environmental Health Sciences 2008 - 2010
  • Bromelain as a Biologically-Based Therapy for IBD awarded by National Institutes of Health 2004 - 2007
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Lichtenstein, GR, and Onken, JE. "Improved Hemoglobin Response with Ferric Carboxymaltose in Patients with Gastrointestinal-Related Iron-Deficiency Anemia Versus Oral Iron." Digestive Diseases and Sciences 63, no. 11 (November 2018): 3009-3019.  Full Text
    • Sandborn, WJ, Bhandari, BR, Fogel, R, Onken, J, Yen, E, Zhao, X, Jiang, Z, Ge, D, Xin, Y, Ye, Z, French, D, Silverman, JA, Kanwar, B, Subramanian, GM, McHutchison, JG, Lee, SD, Shackelton, LM, Pai, RK, Levesque, BG, and Feagan, BG. "Randomised clinical trial: a phase 1, dose-ranging study of the anti-matrix metalloproteinase-9 monoclonal antibody GS-5745 versus placebo for ulcerative colitis." Alimentary pharmacology & therapeutics 44, no. 2 (July 2016): 157-169.  Full Text
    • Regueiro, M, Feagan, BG, Zou, B, Johanns, J, Blank, MA, Chevrier, M, Plevy, S, Popp, J, Cornillie, FJ, Lukas, M, Danese, S, Gionchetti, P, Hanauer, SB, Reinisch, W, Sandborn, WJ, Sorrentino, D, Rutgeerts, P, and PREVENT Study Group, . "Infliximab Reduces Endoscopic, but Not Clinical, Recurrence of Crohn's Disease After Ileocolonic Resection." Gastroenterology 150, no. 7 (June 2016): 1568-1578.  Full Text
    • Roe, MT, Cyr, DD, Eckart, D, Schulte, PJ, Morse, MA, Blackwell, KL, Ready, NE, Zafar, SY, Beaven, AW, Strickler, JH, Onken, JE, Winters, KJ, Houterloot, L, Zamoryakhin, D, Wiviott, SD, White, HD, Prabhakaran, D, Fox, KAA, Armstrong, PW, Ohman, EM, and TRILOGY ACS Investigators, . "Ascertainment, classification, and impact of neoplasm detection during prolonged treatment with dual antiplatelet therapy with prasugrel vs. clopidogrel following acute coronary syndrome." European Heart Journal 37, no. 4 (January 2016): 412-422.  Full Text
    • Rose, S, Shah, BJ, Onken, J, DeCross, AJ, Davis, MH, Jain, R, Kim, LS, Persley, K, Pfeil, SA, and Marks, LN. "Bridging the G-APP: Continuous Professional Development for Gastroenterologists: Replacing MOC with a Model for Lifelong Learning and Accountability." Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association (August 19, 2015).  Full Text
    • Rose, S, Shah, BJ, Onken, J, DeCross, AJ, Davis, MH, Jain, R, Kim, LS, Persley, K, Pfeil, SA, and Marks, LN. "Bridging the G-APP: Continuous Professional Development for Gastroenterologists: Replacing MOC with a Model for Lifelong Learning and Accountability." Gastroenterology (August 19, 2015).  Full Text
    • Onken, JE, and DeCross, AJ. "The education and training committee: at work for the AGA membership." Gastroenterology 147, no. 5 (November 2014): 948-951.  Full Text
    • Oversight Working Network, , Rose, S, Fix, OK, Shah, BJ, Jones, TN, Szyjkowski, RD, Bosworth, BP, Bull-Henry, K, Coyle, W, Gyawali, CP, Koteish, A, Onken, J, Pandolfino, J, Pardi, D, Reddy, G, Richter, S, Savides, TJ, Sedlack, RE, American Association for the Study of Liver Diseases (AASLD), , American College of Gastroenterology (ACG), , American Gastroenterological Association (AGA), , American Neurogastroenterology and Motility Society (ANMS), , American Society for Gastrointestinal Endoscopy (ASGE), , North American Society for Pediatric Gastroenterology, Hepatology, Nutrition (NASPGHAN), , and GI Program Directors Caucus, . "Entrustable professional activities for gastroenterology fellowship training." Gastrointestinal Endoscopy 80, no. 1 (July 2014): 16-27.  Full Text
    • Onken, JE, Bregman, DB, Harrington, RA, Morris, D, Buerkert, J, Hamerski, D, Iftikhar, H, Mangoo-Karim, R, Martin, ER, Martinez, CO, Newman, GE, Qunibi, WY, Ross, DL, Singh, B, Smith, MT, Butcher, A, Koch, TA, and Goodnough, LT. "Ferric carboxymaltose in patients with iron-deficiency anemia and impaired renal function: the REPAIR-IDA trial." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association European Renal Association 29, no. 4 (April 2014): 833-842.  Full Text
    • Onken, JE, Bregman, DB, Harrington, RA, Morris, D, Acs, P, Akright, B, Barish, C, Bhaskar, BS, Smith-Nguyen, GN, Butcher, A, Koch, TA, and Goodnough, LT. "A multicenter, randomized, active-controlled study to investigate the efficacy and safety of intravenous ferric carboxymaltose in patients with iron deficiency anemia." Transfusion 54, no. 2 (February 1, 2014): 306-315.  Full Text
    • Onken, JE, Bregman, DB, Harrington, RA, Morris, D, Acs, P, Akright, B, Barish, C, Bhaskar, BS, Smith-Nguyen, GN, Butcher, A, Koch, TA, and Goodnough, LT. "A multicenter, randomized, active-controlled study to investigate the efficacy and safety of intravenous ferric carboxymaltose in patients with iron deficiency anemia." Transfusion 54, no. 2 (February 2014): 306-315.  Full Text
    • Roe, MT, Armstrong, PW, Fox, KAA, White, HD, Prabhakaran, D, Goodman, SG, Cornel, JH, Bhatt, DL, Clemmensen, P, Martinez, F, Ardissino, D, Nicolau, JC, Boden, WE, Gurbel, PA, Ruzyllo, W, Dalby, AJ, McGuire, DK, Leiva-Pons, JL, Parkhomenko, A, Gottlieb, S, Topacio, GO, Hamm, C, Pavlides, G, Goudev, AR, Oto, A, Tseng, C-D, Merkely, B, Gasparovic, V, Corbalan, R, Cinteză, M, McLendon, RC, Winters, KJ, Brown, EB, Lokhnygina, Y, Aylward, PE, Huber, K, Hochman, JS, Ohman, EM, and TRILOGY ACS Investigators, . "Prasugrel versus clopidogrel for acute coronary syndromes without revascularization." The New England Journal of Medicine 367, no. 14 (October 2012): 1297-1309.  Full Text
    • Szczech, LA, Bregman, DB, Harrington, RA, Morris, D, Butcher, A, Koch, TA, Goodnough, LT, Wolf, M, and Onken, JE. "Randomized evaluation of efficacy and safety of ferric carboxymaltose in patients with iron deficiency anaemia and impaired renal function (REPAIR-IDA): rationale and study design." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association European Renal Association 25, no. 7 (July 2010): 2368-2375.  Full Text
    • Onken, JE. "Is colorectal cancer surveillance cost-effective in patients with ulcerative colitis?." Inflamm Bowel Dis 14 Suppl 2 (October 2008): S196-S197.  Full Text  Link to Item
    • Hampton, DD, Poleski, MH, and Onken, JE. "Inflammatory bowel disease following solid organ transplantation." Clin Immunol 128, no. 3 (September 2008): 287-293.  Full Text  Link to Item
    • Onken, JE, Greer, PK, Calingaert, B, and Hale, LP. "Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro." Clinical Immunology (Orlando, Fla.) 126, no. 3 (March 2008): 345-352.  Full Text
    • Micames, CG, Bentley, R, and Onken, J. "Clinical challenges and images in GI. Invasive candidal enterocolitis." Gastroenterology 133, no. 2 (August 2007): 391-731.  Full Text
    • Arseneau, KO, Sultan, S, Provenzale, DT, Onken, J, Bickston, SJ, Foley, E, Connors, AF, and Cominelli, F. "Do patient preferences influence decisions on treatment for patients with steroid-refractory ulcerative colitis?." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association 4, no. 9 (September 2006): 1135-1142.  Full Text
    • Hampton, D, and Onken, JE. "Review." Gastroenterology & Hepatology 2, no. 8 (August 2006): 597-null. (Review)
    • Hampton, D, and Onken, JE. "Pulmonary eosinophilia following infliximab treatment for Crohn's disease: Review." Gastroenterology and Hepatology 2, no. 8 (August 1, 2006): 597-null.
    • Provenzale, D, and Onken, JE. "TPMT genotype screening for patients about to begin azathioprine treatment--a look at costs and potential benefits." Inflamm Bowel Dis 11, no. 12 (December 2005): 1119-1120.  Link to Item
    • Emmons, KM, McBride, CM, Puleo, E, Pollak, KI, Clipp, E, Kuntz, K, Marcus, BH, Napolitano, M, Onken, J, Farraye, F, and Fletcher, R. "Project PREVENT: a randomized trial to reduce multiple behavioral risk factors for colon cancer." Cancer Epidemiol Biomarkers Prev 14, no. 6 (June 2005): 1453-1459.  Full Text  Link to Item
    • Emmons, KM, McBride, CM, Puleo, E, Pollak, KI, Marcus, BH, Napolitano, M, Clipp, E, Onken, J, Farraye, FA, and Fletcher, R. "Prevalence and predictors of multiple behavioral risk factors for colon cancer." Prev Med 40, no. 5 (May 2005): 527-534.  Full Text  Link to Item
    • Clipp, EC, Carver, EH, Pollak, KI, Puleo, E, Emmons, KM, Onken, J, Farraye, FA, and McBride, CM. "Age-related vulnerabilities of older adults with colon adenomas: evidence from Project Prevent." Cancer 100, no. 5 (March 2004): 1085-1094.  Full Text
    • Sands, BE, Anderson, FH, Bernstein, CN, Chey, WY, Feagan, BG, Fedorak, RN, Kamm, MA, Korzenik, JR, Lashner, BA, Onken, JE, Rachmilewitz, D, Rutgeerts, P, Wild, G, Wolf, DC, Marsters, PA, Travers, SB, Blank, MA, and van Deventer, SJ. "Infliximab maintenance therapy for fistulizing Crohn's disease." The New England Journal of Medicine 350, no. 9 (February 2004): 876-885.  Full Text
    • Sands, BE, Cuffari, C, Katz, J, Kugathasan, S, Onken, J, Vitek, C, and Orenstein, W. "Guidelines for immunizations in patients with inflammatory bowel disease." Inflammatory Bowel Diseases 10, no. 5 (2004): 677-692.  Full Text
    • Bloomfeld, RS, and Onken, JE. "Mercaptopurine metabolite results in clinical gastroenterology practice." Aliment Pharmacol Ther 17, no. 1 (January 2003): 69-73.  Link to Item
    • Onken, JE, Friedman, JY, Subramanian, S, Weinfurt, KP, Reed, SD, Malenbaum, JH, Schmidt, T, and Schulman, KA. "Treatment patterns and costs associated with sessile colorectal polyps." Am J Gastroenterol 97, no. 11 (November 2002): 2896-2901.  Full Text  Link to Item
    • Hanauer, SB, Feagan, BG, Lichtenstein, GR, and Onken, JE. "Maintaining remission in Crohn's Disease." Evidence Based Gastroenterology 3, no. 3 (August 1, 2002): 99-101.  Full Text
    • Bloomfeld, RS, and Onken, JE. "6-mercaptopurine (6MP) metabolite measurements from the clinics: The first year of widespread availability." GASTROENTEROLOGY 120, no. 5 (April 2001): A626-A626.  Link to Item
    • Provenzale, D, and Onken, J. "Surveillance issues in inflammatory bowel disease: ulcerative colitis." J Clin Gastroenterol 32, no. 2 (February 2001): 99-105.  Link to Item
    • Muir, AJ, Provenzale, D, and Onken, JE. "Fistulous complications in Crohn's disease: Impact on health related quality of life (HRQL) and resource utilization." GASTROENTEROLOGY 118, no. 4 (April 2000): A585-A585.  Full Text  Link to Item
    • Onken, JE, Sands, B, Hogezand, R, Haens, G, Braakman, T, DeWoody, K, Schaible, T, Targon, S, Hanauer, S, van Deventer, S, Rutgeerts, P, and Present, D. "Consistent treatment benefit with infliximab in patients with fistulizing Crohn's disease." GASTROENTEROLOGY 116, no. 4 (April 1999): A788-A788.  Link to Item
    • Eloubeidi, MA, and Onken, JE. "Manifestations of Crohn's disease." Digestive Diseases (Basel, Switzerland) 16, no. 4 (July 1998): 262-null.  Full Text
    • Provenzale, D, Wong, JB, Onken, JE, and Lipscomb, J. "Performing a cost-effectiveness analysis: surveillance of patients with ulcerative colitis." The American Journal of Gastroenterology 93, no. 6 (June 1998): 872-880.  Full Text
    • Provenzale, D, Shearin, M, Onken, JE, and Wong, JB. "Surveillance with colectomy for low grade dysplasia increases length and quality of life in ulcerative colitis patients and is cost-effective compared with common medical practices." GASTROENTEROLOGY 114, no. 4 (April 15, 1998): A35-A35.  Full Text  Link to Item
    • Ciaccia, D, Gress, F, Onken, JE, Feczko, J, Chappo, J, and Lehman, G. "Endoscopic ultrasound characteristics in chronic pancreatitis." GASTROINTESTINAL ENDOSCOPY 45, no. 4 (April 1997): 582-582.  Link to Item
    • Davis, WZ, Cotton, PB, Arias, R, Williams, D, and Onken, JE. "ERCP and sphincterotomy in the context of laparoscopic cholecystectomy: academic and community practice patterns and results." Am J Gastroenterol 92, no. 4 (April 1997): 597-601.  Link to Item
    • Onken, JE, Ciaccia, D, Garbutt, JT, and Ortel, TL. "Activated protein C resistance (APCR) phenotype in patients with inflammatory bowel disease." GASTROENTEROLOGY 112, no. 4 (April 1997): A1056-A1056.  Link to Item
    • Ciaccia, D, Gress, F, Onken, JE, Feczko, J, Chapppo, J, and Lehman, G. "Endoscopic ultrasound characteristics in chronic pancreatitis." Gastrointestinal Endoscopy 45, no. 4 (January 1, 1997).  Full Text
    • Ciaccia, D, Onken, J, Chappo, J, Sherman, S, Lehman, G, and Gress, F. "Endoscopic ultrasound guided fine needle aspiration in the diagnosis of chronic pancreatitis (CP)." Gastrointestinal Endoscopy 45, no. 4 (January 1, 1997).  Full Text
    • Jowell, PS, Eisen, G, Onken, J, Bute, BP, and Ginsberg, B. "Patient-controlled analgesia for conscious sedation during endoscopic retrograde cholangiopancreatography: a randomized controlled trial." Gastrointest Endosc 43, no. 5 (May 1996): 490-494.  Link to Item
    • Bouras, EP, McGrath, KM, Ciaccia, D, and Onken, JE. "Correlation of common bile duct diameter by ultrasound and cholangiography." Gastrointestinal Endoscopy 43, no. 4 (April 1, 1996): 337-337.  Link to Item
    • Onken, JE, Brazer, SR, Eisen, GM, Williams, DM, Bouras, EP, DeLong, ER, Long, TT, Pancotto, FS, Rhodes, DL, and Cotton, PB. "Predicting the presence of choledocholithiasis in patients with symptomatic cholelithiasis." Am J Gastroenterol 91, no. 4 (April 1996): 762-767.  Link to Item
    • Provenzale, D, Onken, JE, and Wong, JB. "Prophylactic colectomy or surveillance for patients with ulcerative colitis - A cost-effectiveness analysis." GASTROENTEROLOGY 110, no. 4 (April 1996): A34-A34.  Link to Item
    • Bouras, EP, McGrath, KM, Ciaccia, D, and Onken, JE. "Correlation of common bile duct diameter by ultrasound and cholangiography." Gastrointestinal Endoscopy 43, no. 4 (January 1, 1996): 375-null.  Full Text
    • Strobel, J, Eloubeidi, M, and Onken, J. "Clinical factors predicting good outcome in upper gastrointestinal bleeding." Gastrointestinal Endoscopy 43, no. 4 (January 1, 1996): 321-null.  Full Text
    • ONKEN, JE, BOURAS, EP, WILLIAMS, DM, and BRAZER, SR. "LIVER TEST PATTERNS AS PREDICTORS OF CHOLEDOCHOLITHIASIS." GASTROINTESTINAL ENDOSCOPY 41, no. 4 (April 1995): 409-409.  Full Text  Link to Item
    • Brazer, SR, Onken, JE, Dalton, CB, Smith, JW, and Schiffman, SS. "Effect of different coffees on esophageal acid contact time and symptoms in coffee-sensitive subjects." Physiol Behav 57, no. 3 (March 1995): 563-567.  Link to Item
    • Onken, JE, and Brazer, SR. "Clinical trials. How should they be designed?." Gastrointestinal Endoscopy Clinics of North America 4, no. 2 (April 1994): 423-434. (Review)  Full Text
    • BRAZER, SR, ONKEN, JE, DALTON, CB, SMITH, JW, and SCHIFFMAN, SS. "THE EFFECT OF DIFFERENT COFFEES ON ESOPHAGEAL ACID CONTACT TIME (EACT), HEARTBURN (HB) AND REGURGITATION (RG) IN COFFEE-SENSITIVE SUBJECTS." GASTROENTEROLOGY 104, no. 4 (April 1993): A45-A45.  Link to Item
    • ONKEN, JE, BRAZER, SR, PANCOTTO, FS, LONG, TT, RHODES, DF, and COTTON, PB. "PREDICTION OF CHOLEDOCHOLITHIASIS." GASTROENTEROLOGY 104, no. 4 (April 1993): A19-A19.  Link to Item
    • Onken, JE, and Baillie, J. "A prospective study of esophageal squamous cell carcinoma in achalasia." Gastrointest Endosc 38, no. 6 (November 1992): 738-739.  Link to Item
    • Onken, JE, Pappas, T, and Baillie, J. "Long term results of choledochoduodenostomy in the treatment of choledocholithiasis." Gastrointest Endosc 38, no. 3 (May 1992): 403-405.  Link to Item

  • Conference Papers

    • Fasanya-Uptagraft, H, Basile, J, Lane, A, Boutte, HJ, and Onken, JE. "Outcomes of Inflammatory Bowel Disease After Organ Transplantation (Solid Organ or Hematopoietic Stem Cell Transplantation)." May 2014.  Link to Item
    • Lichtenstein, GR, He, A, Hanauer, B, Keshav, S, and Onken, JE. "Ferric Carboxymaltose: Efficacy and Safety in Patients With Gastrointestinal-Related Iron Deficiency Anemia: A Pooled Analysis." May 2014.  Link to Item
    • Hale, LP, Gottfried, MR, and Onken, JE. "Bromelain treatment of inflammatory bowel disease." April 2004.  Link to Item
    • Parent, J, Branch, MS, Jowell, PS, Affronti, J, Onken, J, Pappas, T, and Baillie, J. "Predictors of improvement following endoscopic management of chronic pancreatitis." 1996.

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