Skip to main content

Jane Elizabeth Onken

Associate Professor of Medicine
Medicine, Gastroenterology
Duke Box 3662, Durham, NC 27710
03137C Hosp South, Durham, NC 27710

Selected Publications


How to Train the Next Generation to Provide High-Quality Peer-Reviews.

Journal Article Clin Gastroenterol Hepatol · September 2022 Full text Link to item Cite

Reply.

Journal Article Clin Gastroenterol Hepatol · July 2022 Full text Link to item Cite

Reply.

Journal Article Clin Gastroenterol Hepatol · March 2022 Full text Link to item Cite

Issue Highlights

Journal Article Clinical Gastroenterology and Hepatology · February 1, 2022 Full text Cite

Unconscious Bias in Peer Review.

Journal Article Clin Gastroenterol Hepatol · March 2021 Full text Link to item Cite

Education and Trainee Perspectives Section.

Journal Article Clin Gastroenterol Hepatol · January 2021 Full text Link to item Cite

Issue Highlights

Journal Article Clinical Gastroenterology and Hepatology · January 1, 2021 Full text Cite

Issue Highlights

Journal Article Clinical Gastroenterology and Hepatology · December 1, 2019 Full text Cite

Issue Highlights

Journal Article Clinical Gastroenterology and Hepatology · December 1, 2018 Full text Cite

Improved Hemoglobin Response with Ferric Carboxymaltose in Patients with Gastrointestinal-Related Iron-Deficiency Anemia Versus Oral Iron.

Journal Article Dig Dis Sci · November 2018 AIMS: To compare the efficacy and safety of intravenous (IV) ferric carboxymaltose (FCM) versus oral iron and other IV iron therapies in patients with iron-deficiency anemia (IDA) resulting from gastrointestinal (GI) disorders. METHODS: A pooled analysis o ... Full text Link to item Cite

Issue Highlights

Journal Article Clinical Gastroenterology and Hepatology · November 1, 2017 Full text Cite

Randomised clinical trial: a phase 1, dose-ranging study of the anti-matrix metalloproteinase-9 monoclonal antibody GS-5745 versus placebo for ulcerative colitis.

Journal Article Aliment Pharmacol Ther · July 2016 BACKGROUND: Matrix metalloproteinase-9 is a proteolytic enzyme whose expression is increased in ulcerative colitis. AIM: To evaluate the safety and efficacy of GS-5745, a fully humanised anti-matrix metalloproteinase-9 monoclonal antibody, in moderately-to ... Full text Link to item Cite

Infliximab Reduces Endoscopic, but Not Clinical, Recurrence of Crohn's Disease After Ileocolonic Resection.

Journal Article Gastroenterology · June 2016 BACKGROUND & AIMS: Most patients with Crohn's disease (CD) eventually require an intestinal resection. However, CD frequently recurs after resection. We performed a randomized trial to compare the ability of infliximab vs placebo to prevent CD recurrence. ... Full text Link to item Cite

Ascertainment, classification, and impact of neoplasm detection during prolonged treatment with dual antiplatelet therapy with prasugrel vs. clopidogrel following acute coronary syndrome.

Journal Article Eur Heart J · January 21, 2016 AIMS: Studies have suggested increased cancer incidence associated with long-term dual antiplatelet therapy (DAPT) for acute coronary syndrome (ACS). We evaluated cancer incidence and treatment-related differences in an analysis of DAPT for ACS. METHODS AN ... Full text Link to item Cite

How to Train the Next Generation to Provide High-Quality Peer-Reviews.

Journal Article Clin Gastroenterol Hepatol · September 2022 Full text Link to item Cite

Reply.

Journal Article Clin Gastroenterol Hepatol · July 2022 Full text Link to item Cite

Reply.

Journal Article Clin Gastroenterol Hepatol · March 2022 Full text Link to item Cite

Issue Highlights

Journal Article Clinical Gastroenterology and Hepatology · February 1, 2022 Full text Cite

Unconscious Bias in Peer Review.

Journal Article Clin Gastroenterol Hepatol · March 2021 Full text Link to item Cite

Education and Trainee Perspectives Section.

Journal Article Clin Gastroenterol Hepatol · January 2021 Full text Link to item Cite

Issue Highlights

Journal Article Clinical Gastroenterology and Hepatology · January 1, 2021 Full text Cite

Issue Highlights

Journal Article Clinical Gastroenterology and Hepatology · December 1, 2019 Full text Cite

Issue Highlights

Journal Article Clinical Gastroenterology and Hepatology · December 1, 2018 Full text Cite

Improved Hemoglobin Response with Ferric Carboxymaltose in Patients with Gastrointestinal-Related Iron-Deficiency Anemia Versus Oral Iron.

Journal Article Dig Dis Sci · November 2018 AIMS: To compare the efficacy and safety of intravenous (IV) ferric carboxymaltose (FCM) versus oral iron and other IV iron therapies in patients with iron-deficiency anemia (IDA) resulting from gastrointestinal (GI) disorders. METHODS: A pooled analysis o ... Full text Link to item Cite

Issue Highlights

Journal Article Clinical Gastroenterology and Hepatology · November 1, 2017 Full text Cite

Randomised clinical trial: a phase 1, dose-ranging study of the anti-matrix metalloproteinase-9 monoclonal antibody GS-5745 versus placebo for ulcerative colitis.

Journal Article Aliment Pharmacol Ther · July 2016 BACKGROUND: Matrix metalloproteinase-9 is a proteolytic enzyme whose expression is increased in ulcerative colitis. AIM: To evaluate the safety and efficacy of GS-5745, a fully humanised anti-matrix metalloproteinase-9 monoclonal antibody, in moderately-to ... Full text Link to item Cite

Infliximab Reduces Endoscopic, but Not Clinical, Recurrence of Crohn's Disease After Ileocolonic Resection.

Journal Article Gastroenterology · June 2016 BACKGROUND & AIMS: Most patients with Crohn's disease (CD) eventually require an intestinal resection. However, CD frequently recurs after resection. We performed a randomized trial to compare the ability of infliximab vs placebo to prevent CD recurrence. ... Full text Link to item Cite

Ascertainment, classification, and impact of neoplasm detection during prolonged treatment with dual antiplatelet therapy with prasugrel vs. clopidogrel following acute coronary syndrome.

Journal Article Eur Heart J · January 21, 2016 AIMS: Studies have suggested increased cancer incidence associated with long-term dual antiplatelet therapy (DAPT) for acute coronary syndrome (ACS). We evaluated cancer incidence and treatment-related differences in an analysis of DAPT for ACS. METHODS AN ... Full text Link to item Cite

Ferric carboxymaltose in patients with iron-deficiency anemia and impaired renal function: the REPAIR-IDA trial.

Journal Article Nephrol Dial Transplant · April 2014 BACKGROUND: Iron-deficiency anemia in non-dialysis-dependent chronic kidney disease (NDD-CKD) frequently requires parenteral iron replacement, but existing therapies often require multiple administrations. We evaluated the efficacy and cardiovascular safet ... Full text Link to item Cite

A multicenter, randomized, active-controlled study to investigate the efficacy and safety of intravenous ferric carboxymaltose in patients with iron deficiency anemia.

Journal Article Transfusion · February 2014 BACKGROUND: Many patients receiving oral iron for iron deficiency anemia (IDA) cannot tolerate or fail to respond to therapy, and existing intravenous (IV) iron formulations often require repeated administrations. Ferric carboxymaltose (FCM), a nondextran ... Full text Link to item Cite

Prasugrel versus clopidogrel for acute coronary syndromes without revascularization.

Journal Article N Engl J Med · October 4, 2012 BACKGROUND: The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated. METHODS: In this double-blind, randomized trial, ... Full text Link to item Cite

Randomized evaluation of efficacy and safety of ferric carboxymaltose in patients with iron deficiency anaemia and impaired renal function (REPAIR-IDA): rationale and study design.

Journal Article Nephrol Dial Transplant · July 2010 BACKGROUND: Patients with iron deficiency anaemia (IDA) in the setting of non-dialysis-dependent chronic kidney disease (NDD-CKD) may benefit from treatment with intravenous (IV) iron. Ferric carboxymaltose (FCM) is a novel IV iron formulation designed to ... Full text Link to item Cite

Inflammatory bowel disease following solid organ transplantation.

Journal Article Clin Immunol · September 2008 Inflammatory bowel disease (IBD) is a T cell driven inflammatory condition of the gut. Following solid organ transplantation (SOT), de novo IBD has been reported despite anti-T cell therapy for the prevention of organ rejection. This paradox is illustrated ... Full text Link to item Cite

Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro.

Journal Article Clin Immunol · March 2008 Oral bromelain has been anecdotally reported to decrease inflammation in ulcerative colitis (UC). Proteolytically active bromelain is known to decrease expression of mRNAs encoding pro-inflammatory cytokines by human leukocytes in vitro. To assess the effe ... Full text Link to item Cite

Do patient preferences influence decisions on treatment for patients with steroid-refractory ulcerative colitis?

Journal Article Clin Gastroenterol Hepatol · September 2006 BACKGROUND & AIMS: Patients with steroid-refractory ulcerative colitis face a difficult treatment decision between colectomy and therapy with infliximab or cyclosporine. The aim of this study was to understand how individual patient preferences for the var ... Full text Link to item Cite

Review.

Journal Article Gastroenterol Hepatol (N Y) · August 2006 Link to item Cite

Pulmonary eosinophilia following infliximab treatment for Crohn's disease: Review

Journal Article Gastroenterology and Hepatology · August 1, 2006 Cite

Project PREVENT: a randomized trial to reduce multiple behavioral risk factors for colon cancer.

Journal Article Cancer Epidemiol Biomarkers Prev · June 2005 BACKGROUND: This report examines the outcome data for Project PREVENT, a two-site randomized control trial designed to reduce behavioral risk factors for colorectal cancer among individuals who have been diagnosed with adenomatous colon polyps. METHODS: Th ... Full text Link to item Cite

Prevalence and predictors of multiple behavioral risk factors for colon cancer.

Journal Article Prev Med · May 2005 OBJECTIVES: This paper examines the prevalence of behavioral risk factors for colorectal cancer (CRC) (e.g., red meat consumption, fruit and vegetable intake, multivitamin intake, alcohol, smoking, and physical inactivity), co-occurrence among these behavi ... Full text Link to item Cite

Guidelines for immunizations in patients with inflammatory bowel disease.

Journal Article Inflamm Bowel Dis · September 2004 During the past 2 decades, medical therapy for Crohn's disease (CD) and ulcerative colitis (UC) has grown to incorporate a variety of immunesuppressing agents. At the same time, basic insights into the aberrant mucosal immune response underlying inflammato ... Full text Link to item Cite

Bromelain treatment of inflammatory bowel disease

Conference GASTROENTEROLOGY · April 1, 2004 Link to item Cite

Age-related vulnerabilities of older adults with colon adenomas: evidence from Project Prevent.

Journal Article Cancer · March 1, 2004 BACKGROUND: This report addresses the interface between cancer and aging in the context of colorectal carcinoma (CRC), the second leading cause of cancer death in the U.S. overall and the first leading cause among individuals age > or = 75 years. Because p ... Full text Link to item Cite

Infliximab maintenance therapy for fistulizing Crohn's disease.

Journal Article N Engl J Med · February 26, 2004 Featured Publication BACKGROUND: Infliximab, a monoclonal antibody against tumor necrosis factor, is an effective maintenance therapy for patients with Crohn's disease without fistulas. It is not known whether infliximab is an effective maintenance therapy for patients with fi ... Full text Link to item Cite

Mercaptopurine metabolite results in clinical gastroenterology practice.

Journal Article Aliment Pharmacol Ther · January 2003 Featured Publication BACKGROUND: Azathioprine (AZA) and its active metabolite mercaptopurine (MP) are frequently used in the management of inflammatory bowel disease. Measurement of the AZA/MP metabolites, thioguanine (TG) and methylmercaptopurine (MMP), has been suggested as ... Full text Link to item Cite

Treatment patterns and costs associated with sessile colorectal polyps.

Journal Article Am J Gastroenterol · November 2002 Featured Publication OBJECTIVES: Because of the paucity of existing literature on treatment and costs associated with sessile lesions, the objectives of this study were to perform a retrospective analysis on patients with sessile polyps to identify patient and polyp characteri ... Full text Link to item Cite

Maintaining remission in Crohn's Disease

Journal Article Evidence-Based Gastroenterology · August 1, 2002 Full text Cite

Surveillance issues in inflammatory bowel disease: ulcerative colitis.

Journal Article J Clin Gastroenterol · February 2001 This review article on the surveillance of patients with ulcerative colitis provides an overview of the criteria for evaluating screening and surveillance programs and applies the criteria to the available evidence to determine the effectiveness of the sur ... Full text Link to item Cite

Performing a cost-effectiveness analysis: surveillance of patients with ulcerative colitis.

Journal Article Am J Gastroenterol · June 1998 Featured Publication OBJECTIVE: To illustrate the principles of cost-effectiveness analysis, this third article in the "Primer on Economic Analysis for the Gastroenterologist" applies published criteria for appraising an economic analysis to a study of the cost-effectiveness o ... Full text Link to item Cite

Manifestations of Crohn's disease.

Journal Article Dig Dis · 1998 Featured Publication Full text Link to item Cite

ERCP and sphincterotomy in the context of laparoscopic cholecystectomy: academic and community practice patterns and results.

Journal Article Am J Gastroenterol · April 1997 OBJECTIVE: To study the effect of practice setting and practitioner experience on the use and results of ERCP and sphincterotomy in the context of laparoscopic cholecystectomy. METHODS: Data were collected on 780 ERCPs performed before or after laparoscopi ... Link to item Cite

Endoscopic ultrasound characteristics in chronic pancreatitis

Journal Article GASTROINTESTINAL ENDOSCOPY · April 1, 1997 Link to item Cite

Endoscopic ultrasound guided fine needle aspiration in the diagnosis of chronic pancreatitis (CP)

Journal Article Gastrointestinal Endoscopy · January 1, 1997 Differentiation of malignant disease from chronic pancreatitis (CP) in patients with abnormal pancreatic findings on CT or ERCP is often difficult. This study was designed to evaluate the role of endoscopic ultrasound (EUS) guided fine needle aspiration (F ... Full text Cite

Patient-controlled analgesia for conscious sedation during endoscopic retrograde cholangiopancreatography: a randomized controlled trial.

Journal Article Gastrointest Endosc · May 1996 BACKGROUND: Adequate comfort is essential to patients undergoing invasive procedures. This study was designed to evaluate whether patient-controlled analgesia could improve sedation for ERCP. METHODS: Patients were randomized to receive standard sedation ( ... Full text Link to item Cite

Predicting the presence of choledocholithiasis in patients with symptomatic cholelithiasis.

Journal Article Am J Gastroenterol · April 1996 OBJECTIVES: Accurate preoperative prediction of choledocholithiasis is essential in order to minimize patient risk and curtail health care expenditures. This study was designed to identify independent risk factors for choledocholithiasis in patients who ha ... Link to item Cite

Correlation of common bile duct diameter by ultrasound and cholangiography.

Journal Article GASTROINTESTINAL ENDOSCOPY · April 1, 1996 Link to item Cite

Predictors of improvement following endoscopic management of chronic pancreatitis

Conference Gastrointestinal Endoscopy · 1996 Background: Endoscopic therapy is an accepted treatment for pain in chronic pancreatitis, in addition to traditional management. However, guidelines for selecting treatment options have yet to be established. This study addresses 2 questions: (a) which pat ... Cite

Clinical factors predicting good outcome in upper gastrointestinal bleeding

Journal Article Gastrointestinal Endoscopy · January 1, 1996 The level of care provided to patients with upper gastrointestinal bleeding (UGIB) prior to endoscopy is usually based on clinical, non-endoscopic factors. The goal of this study is to identify features of the history, physical exam, and laboratory data wh ... Full text Cite

Correlation of common bile duct diameter by ultrasound and cholangiography

Journal Article Gastrointestinal Endoscopy · January 1, 1996 Common bile duct (CBD) diameter is often measured during ultrasound (U/S) of the liver and biliary tree. However, to date, no study has directly compared the measurements obtained during U/S to those obtained at ERC. Objectives: (I) To assess the degree of ... Full text Cite

Liver test patterns as predictors of choledocholithiasis

Journal Article Gastrointestinal Endoscopy · April 1995 Full text Cite

Effect of different coffees on esophageal acid contact time and symptoms in coffee-sensitive subjects.

Journal Article Physiol Behav · March 1995 The purpose of this study was to correlate the effects of different coffees on esophageal acid contact, heartburn, and regurgitation in patients with coffee-sensitivity. Twenty volunteers with coffee-sensitivity were studied in a double-blind, 3 period, cr ... Full text Link to item Cite

Clinical trials. How should they be designed?

Journal Article Gastrointest Endosc Clin N Am · April 1994 The fundamental principles of clinical trial design include (1) a priori formulation of a specific research question, (2) precise description of the population to be studied, (3) limitation of the effects of chance by predetermining the study hypothesis an ... Link to item Cite

PREDICTION OF CHOLEDOCHOLITHIASIS

Journal Article GASTROENTEROLOGY · April 1, 1993 Link to item Cite