Journal ArticleGastro Hep Adv · 2024
BACKGROUND AND AIMS: Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions influenced heavily by environmental factors. DNA methylation is a form of epigenetic regulation linking environmental stimuli to gene expression changes and inflamm ...
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Journal ArticleDig Dis Sci · November 2018
AIMS: To compare the efficacy and safety of intravenous (IV) ferric carboxymaltose (FCM) versus oral iron and other IV iron therapies in patients with iron-deficiency anemia (IDA) resulting from gastrointestinal (GI) disorders. METHODS: A pooled analysis o ...
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Journal ArticleAliment Pharmacol Ther · July 2016
BACKGROUND: Matrix metalloproteinase-9 is a proteolytic enzyme whose expression is increased in ulcerative colitis. AIM: To evaluate the safety and efficacy of GS-5745, a fully humanised anti-matrix metalloproteinase-9 monoclonal antibody, in moderately-to ...
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Journal ArticleGastroenterology · June 2016
BACKGROUND & AIMS: Most patients with Crohn's disease (CD) eventually require an intestinal resection. However, CD frequently recurs after resection. We performed a randomized trial to compare the ability of infliximab vs placebo to prevent CD recurrence. ...
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Journal ArticleEur Heart J · January 21, 2016
AIMS: Studies have suggested increased cancer incidence associated with long-term dual antiplatelet therapy (DAPT) for acute coronary syndrome (ACS). We evaluated cancer incidence and treatment-related differences in an analysis of DAPT for ACS. METHODS AN ...
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Journal ArticleNephrol Dial Transplant · April 2014
BACKGROUND: Iron-deficiency anemia in non-dialysis-dependent chronic kidney disease (NDD-CKD) frequently requires parenteral iron replacement, but existing therapies often require multiple administrations. We evaluated the efficacy and cardiovascular safet ...
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Journal ArticleTransfusion · February 2014
BACKGROUND: Many patients receiving oral iron for iron deficiency anemia (IDA) cannot tolerate or fail to respond to therapy, and existing intravenous (IV) iron formulations often require repeated administrations. Ferric carboxymaltose (FCM), a nondextran ...
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Journal ArticleN Engl J Med · October 4, 2012
BACKGROUND: The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated. METHODS: In this double-blind, randomized trial, ...
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Journal ArticleNephrol Dial Transplant · July 2010
BACKGROUND: Patients with iron deficiency anaemia (IDA) in the setting of non-dialysis-dependent chronic kidney disease (NDD-CKD) may benefit from treatment with intravenous (IV) iron. Ferric carboxymaltose (FCM) is a novel IV iron formulation designed to ...
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Journal ArticleClin Immunol · September 2008
Inflammatory bowel disease (IBD) is a T cell driven inflammatory condition of the gut. Following solid organ transplantation (SOT), de novo IBD has been reported despite anti-T cell therapy for the prevention of organ rejection. This paradox is illustrated ...
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Journal ArticleClin Immunol · March 2008
Oral bromelain has been anecdotally reported to decrease inflammation in ulcerative colitis (UC). Proteolytically active bromelain is known to decrease expression of mRNAs encoding pro-inflammatory cytokines by human leukocytes in vitro. To assess the effe ...
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Journal ArticleClin Gastroenterol Hepatol · September 2006
BACKGROUND & AIMS: Patients with steroid-refractory ulcerative colitis face a difficult treatment decision between colectomy and therapy with infliximab or cyclosporine. The aim of this study was to understand how individual patient preferences for the var ...
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Journal ArticleCancer Epidemiol Biomarkers Prev · June 2005
BACKGROUND: This report examines the outcome data for Project PREVENT, a two-site randomized control trial designed to reduce behavioral risk factors for colorectal cancer among individuals who have been diagnosed with adenomatous colon polyps. METHODS: Th ...
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Journal ArticlePrev Med · May 2005
OBJECTIVES: This paper examines the prevalence of behavioral risk factors for colorectal cancer (CRC) (e.g., red meat consumption, fruit and vegetable intake, multivitamin intake, alcohol, smoking, and physical inactivity), co-occurrence among these behavi ...
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Journal ArticleInflamm Bowel Dis · September 2004
During the past 2 decades, medical therapy for Crohn's disease (CD) and ulcerative colitis (UC) has grown to incorporate a variety of immunesuppressing agents. At the same time, basic insights into the aberrant mucosal immune response underlying inflammato ...
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Journal ArticleCancer · March 1, 2004
BACKGROUND: This report addresses the interface between cancer and aging in the context of colorectal carcinoma (CRC), the second leading cause of cancer death in the U.S. overall and the first leading cause among individuals age > or = 75 years. Because p ...
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Journal ArticleN Engl J Med · February 26, 2004
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BACKGROUND: Infliximab, a monoclonal antibody against tumor necrosis factor, is an effective maintenance therapy for patients with Crohn's disease without fistulas. It is not known whether infliximab is an effective maintenance therapy for patients with fi ...
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Journal ArticleAliment Pharmacol Ther · January 2003
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BACKGROUND: Azathioprine (AZA) and its active metabolite mercaptopurine (MP) are frequently used in the management of inflammatory bowel disease. Measurement of the AZA/MP metabolites, thioguanine (TG) and methylmercaptopurine (MMP), has been suggested as ...
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Journal ArticleAm J Gastroenterol · November 2002
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OBJECTIVES: Because of the paucity of existing literature on treatment and costs associated with sessile lesions, the objectives of this study were to perform a retrospective analysis on patients with sessile polyps to identify patient and polyp characteri ...
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Journal ArticleJ Clin Gastroenterol · February 2001
This review article on the surveillance of patients with ulcerative colitis provides an overview of the criteria for evaluating screening and surveillance programs and applies the criteria to the available evidence to determine the effectiveness of the sur ...
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Journal ArticleAm J Gastroenterol · June 1998
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OBJECTIVE: To illustrate the principles of cost-effectiveness analysis, this third article in the "Primer on Economic Analysis for the Gastroenterologist" applies published criteria for appraising an economic analysis to a study of the cost-effectiveness o ...
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Journal ArticleAm J Gastroenterol · April 1997
OBJECTIVE: To study the effect of practice setting and practitioner experience on the use and results of ERCP and sphincterotomy in the context of laparoscopic cholecystectomy. METHODS: Data were collected on 780 ERCPs performed before or after laparoscopi ...
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Journal ArticleGastrointestinal Endoscopy · January 1, 1997
Differentiation of malignant disease from chronic pancreatitis (CP) in patients with abnormal pancreatic findings on CT or ERCP is often difficult. This study was designed to evaluate the role of endoscopic ultrasound (EUS) guided fine needle aspiration (F ...
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Journal ArticleGastrointest Endosc · May 1996
BACKGROUND: Adequate comfort is essential to patients undergoing invasive procedures. This study was designed to evaluate whether patient-controlled analgesia could improve sedation for ERCP. METHODS: Patients were randomized to receive standard sedation ( ...
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Journal ArticleAm J Gastroenterol · April 1996
OBJECTIVES: Accurate preoperative prediction of choledocholithiasis is essential in order to minimize patient risk and curtail health care expenditures. This study was designed to identify independent risk factors for choledocholithiasis in patients who ha ...
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ConferenceGastrointestinal Endoscopy · 1996
Background: Endoscopic therapy is an accepted treatment for pain in chronic pancreatitis, in addition to traditional management. However, guidelines for selecting treatment options have yet to be established. This study addresses 2 questions: (a) which pat ...
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Journal ArticleGastrointestinal Endoscopy · January 1, 1996
The level of care provided to patients with upper gastrointestinal bleeding (UGIB) prior to endoscopy is usually based on clinical, non-endoscopic factors. The goal of this study is to identify features of the history, physical exam, and laboratory data wh ...
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Journal ArticleGastrointestinal Endoscopy · January 1, 1996
Common bile duct (CBD) diameter is often measured during ultrasound (U/S) of the liver and biliary tree. However, to date, no study has directly compared the measurements obtained during U/S to those obtained at ERC. Objectives: (I) To assess the degree of ...
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Journal ArticlePhysiol Behav · March 1995
The purpose of this study was to correlate the effects of different coffees on esophageal acid contact, heartburn, and regurgitation in patients with coffee-sensitivity. Twenty volunteers with coffee-sensitivity were studied in a double-blind, 3 period, cr ...
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Journal ArticleGastrointest Endosc Clin N Am · April 1994
The fundamental principles of clinical trial design include (1) a priori formulation of a specific research question, (2) precise description of the population to be studied, (3) limitation of the effects of chance by predetermining the study hypothesis an ...
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