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Cytoskeletal regulation of TRPC channels in the cardiorenal system.

Publication ,  Journal Article
Stiber, JA; Tang, Y; Li, T; Rosenberg, PB
Published in: Curr Hypertens Rep
December 2012

Transient receptor potential canonical (TRPC) channels have been implicated in several aspects of cardiorenal physiology including regulation of blood pressure, vasoreactivity, vascular remodeling, and glomerular filtration. Gain and loss of function studies also support the role of TRPC channels in adverse remodeling associated with cardiac hypertrophy and heart failure. This review discusses TRP channels in the cardiovascular and glomerular filtration systems and their role in disease pathogenesis. We describe the regulation of gating of TRPC channels in the cardiorenal system as well as the influence on activation of these channels by the underlying cytoskeleton and scaffolding proteins. We then focus on the role of TRP channels in the pathogenesis of adverse cardiac remodeling and as potential therapeutic targets in the treatment of heart failure.

Duke Scholars

Published In

Curr Hypertens Rep

DOI

EISSN

1534-3111

Publication Date

December 2012

Volume

14

Issue

6

Start / End Page

492 / 497

Location

United States

Related Subject Headings

  • TRPC Cation Channels
  • Kidney Glomerulus
  • Hypertension
  • Humans
  • Heart Failure
  • Cytoskeleton
  • Cardio-Renal Syndrome
  • Calcium
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
 

Citation

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MLA
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Stiber, J. A., Tang, Y., Li, T., & Rosenberg, P. B. (2012). Cytoskeletal regulation of TRPC channels in the cardiorenal system. Curr Hypertens Rep, 14(6), 492–497. https://doi.org/10.1007/s11906-012-0313-4
Stiber, Jonathan A., Youlan Tang, TianYu Li, and Paul B. Rosenberg. “Cytoskeletal regulation of TRPC channels in the cardiorenal system.Curr Hypertens Rep 14, no. 6 (December 2012): 492–97. https://doi.org/10.1007/s11906-012-0313-4.
Stiber JA, Tang Y, Li T, Rosenberg PB. Cytoskeletal regulation of TRPC channels in the cardiorenal system. Curr Hypertens Rep. 2012 Dec;14(6):492–7.
Stiber, Jonathan A., et al. “Cytoskeletal regulation of TRPC channels in the cardiorenal system.Curr Hypertens Rep, vol. 14, no. 6, Dec. 2012, pp. 492–97. Pubmed, doi:10.1007/s11906-012-0313-4.
Stiber JA, Tang Y, Li T, Rosenberg PB. Cytoskeletal regulation of TRPC channels in the cardiorenal system. Curr Hypertens Rep. 2012 Dec;14(6):492–497.
Journal cover image

Published In

Curr Hypertens Rep

DOI

EISSN

1534-3111

Publication Date

December 2012

Volume

14

Issue

6

Start / End Page

492 / 497

Location

United States

Related Subject Headings

  • TRPC Cation Channels
  • Kidney Glomerulus
  • Hypertension
  • Humans
  • Heart Failure
  • Cytoskeleton
  • Cardio-Renal Syndrome
  • Calcium
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences