Cytoskeletal regulation of TRPC channels in the cardiorenal system.

Journal Article (Journal Article;Review)

Transient receptor potential canonical (TRPC) channels have been implicated in several aspects of cardiorenal physiology including regulation of blood pressure, vasoreactivity, vascular remodeling, and glomerular filtration. Gain and loss of function studies also support the role of TRPC channels in adverse remodeling associated with cardiac hypertrophy and heart failure. This review discusses TRP channels in the cardiovascular and glomerular filtration systems and their role in disease pathogenesis. We describe the regulation of gating of TRPC channels in the cardiorenal system as well as the influence on activation of these channels by the underlying cytoskeleton and scaffolding proteins. We then focus on the role of TRP channels in the pathogenesis of adverse cardiac remodeling and as potential therapeutic targets in the treatment of heart failure.

Full Text

Duke Authors

Cited Authors

  • Stiber, JA; Tang, Y; Li, T; Rosenberg, PB

Published Date

  • December 2012

Published In

Volume / Issue

  • 14 / 6

Start / End Page

  • 492 - 497

PubMed ID

  • 23054893

Pubmed Central ID

  • PMC3532928

Electronic International Standard Serial Number (EISSN)

  • 1534-3111

Digital Object Identifier (DOI)

  • 10.1007/s11906-012-0313-4


  • eng

Conference Location

  • United States